李迎君科研成果

教师主页 团队成员 科研项目 研究领域 学术成果 教学 科研分享 新闻动态 疼痛医学中心 成果介绍 软件 毕业去向 加入我们 联系我们 李迎君 Google Scholar 研究副教授 前沿与交叉科学研究院 李迎君博士，南方科技大学研究副教授，硕士生导师，生物医药研究院院长助理。从事药物化学、药理学研究与新药研发。2015年毕业于中国科学院大学（广州生物医药与健康研究院），获得药物化学博士学位。2015-2017年在马里兰大学药学院从事抗肿瘤新药药理博士后研究。2017-2019年在约翰霍普金斯大学医学院 (刘钧(Jun O Liu) 教授课题组)从事化学生物学、药理学博士后研究。近年来围绕新冠病毒感染、癌症等关键科学问题和重大疾病临床需求，聚焦创新药物研究中的新靶标活性分子筛选和成药性优化，综合采用药物化学和化学生物学理论技术突破活性、药物代谢（ADME）瓶颈。作为核心发明人开发处于II期临床试验阶段的抗新冠口服候选药物SHEN26。 迄今共发表论文24篇。以第一作者/通讯作者在Sci. Transl. Med. (science 子刊IF=18), Signal Transduct. Target Ther. (IF=38), J. Med. Chem. (IF=8) 等专业学术期刊发表学术论文13篇（影响因子大于20的2篇，大于10的2篇）；其中1篇被选为封面文章（J Med Chem, 2022;65(4):2785-2793, inside cover）。申请专利20余项，其中包括国际专利（WIPO）3项，美国专利2项，印度专利1项。两项科研成果已转化或与企业联合开发。主持六项在研基金项目，包括两项国家级基金项目：国家自然科学基金原创探索计划项目、国家自然科学基金青年基金项目，两项省级基金项目，一项市级基金和一项国家重点实验室开放基金项目。作为核心成员参与国家重点研发计划项目、广东省重点领域研发计划等项目共三项。担任Pharmaceutical Fronts杂志青年编委。 个人简介 个人简介 研究领域 药物化学，药理学，小分子药物新药研发 学术成果 查看更多 代表文章： 1. Qifan Zhou,# Sidi Yang,# Liu Cao,# Yang Yang,# Tiefeng Xu,#Qishu Chen, Hongzhou Lu,  Yingjun Li,* Deyin Guo,* and Xumu Zhang*. Preclinical characterization of ATV014, an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside for the treatment of SARS-CoV-2. Signal Transduction and Targeted Therapy. 2023, 8, 27  2. Liu Cao#, Yingjun Li#,*, Sidi Yang#, Guanguan Li#, Qifan Zhou#, Jing Sun#, Tiefeng Xu, Yang Yang, Ruyan Liao, Yongxia Shi, Yujian Yang, Tiaozhen Zhu, Siyao Huang, Yanxi Ji, Feng Cong, Yinzhu Luo, Yujun Zhu, Hemi Luan, Huan Zhang, Jingdiao Chen, Xue Liu, Renru Luo, Lihong Liu, Ping Wang, Yang Yu, Fan Xing, Bixia Ke, Huanying Zheng, Xiaoling Deng, Wenyong Zhang, Chuwen Lin, Mang Shi, ChunMei Li, Yu Zhang, Lu Zhang, Jun Dai, Hongzhou Lu, Jincun Zhao*, Xumu Zhang*, Deyin Guo*; The adenosine analogue prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants, Science Translational Medicine. 2022, 14(661), eabm7621 3. Yujian Yang#, Liu Cao#, Ming Yan#, Jun Zhou, Sidi Yang, Tiefeng Xu, Siyao Huang, Kun Li, Qifan Zhou, Guanguan Li, Yujun Zhu, Feng Cong, Hongmin Zhang*, Deyin Guo*, Yingjun Li*, Xumu Zhang*. Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2, Antiviral Research. doi: 10.1016/j.antiviral.2023.105586 4. Qifan Zhou#, Yinzhu Luo#, Yujun Zhu#, Qishu Chen, Jingfei Qiu, Feng Cong*, Yingjun Li*, and Xumu Zhang*. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. European Journal of Medicinal Chemistry. 249, 115113  5. Huimin Cheng#, Liangbing Fu#,*, Xia Yang#, Yujian Yang, Zhening Zhang, Yuan Tao, Yujun Zhu, Feng Cong, Junting Wan, Zhengchao Tu, Jianxin Chen*, Yingjun Li*. Screening and identification of 3-aryl-quinolin-2-one derivatives as antiviral agents against influenza A. Journal of medical virology. 2022; e28327.  6. Yujian Yang†, Qiuchun Yu†, Lean Hu†, Botao Du, Ruxi Qi, Yu Chang, Zhengchao Tu, Qingwen Zhang*, Zhang Zhang*, Yingjun Li*, Xumu Zhang*; Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia, European Journal of Medicinal Chemistry. 2022, 244:114731  7. Yingjun Li#, Liu Cao#, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, Yinzhu Luo, Guijiang Chen, Guanguan Li, Ping Wang, Fan Xing, Yanxi Ji, Jincun Zhao, Yu Zhang*, Deyin Guo*, Xumu Zhang*; Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models, Journal of Medicinal Chemistry. 2022, 65, 2785–2793.  8. Yingjun Li#,*, Yongjun Huang#, Huimin Cheng#, Fang Xu, Ruxi Qi, Botao Dai, Yujian Yang, Zhengchao Tu, Lijie Peng* and Zhang Zhang*; Discovery of BRAF/HDACs Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells, Chem. 10:910353.  9. Yingjun Li; Kalyan Kumar Pasunooti; Hanjing Peng; Ruo-Jing Li; Wei Q.Shi; Wukun Liu; Zhiqiang Cheng; Sarah A. Head; Jun O. Liu*; Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors, ACS Medicinal Chemistry Letters. 2020, 11(6):1111-1117.  10. Wei Yang#; Yingjun Li#; Yong Ai; Obinna N. Obianom; Dong Guo; Hong Yang; Srilatha Sakamuru; Menghang Xia; Yan Shu*; Fengtian Xue*; Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation, Journal of Medicinal Chemistry. 2019, 62(24): 11151-11164. 11. Yingjun Li, # Kalyan Kumar Pasunooti, # Ruo-Jing Li, Wukun Liu, Sarah A. Head, Wei Q. Shi, Jun O. Liu. Novel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition. Journal of Medicinal Chemistry. 2018, 61, 11158–11168.  12. Yingjun Li, Huimin Cheng, Zhang Zhang, Xiaoxi Zhuang, Jinfeng Luo, Huoyou Long, Yang Zhou, Yong Xu, Rana Taghipouran, Dan Li, Adam Patterson, Jeff Smaill, Zhengchao Tu, Donghai Wu, Xiaomei Ren, and Ke Ding. N-(3-Ethynyl-2,4-difluorophenyl) sulfonamide Derivatives as Selective RAF Inhibitors. ACS Medicinal Chemistry Letters. 2015, 6, 543-547.  13. Yingjun Li, Xiaoxi Zhuang, Lijie Peng*, Ke Ding*. Synthesis and Biological Evaluation of 2,7-diphenyl-4H-pyrido[1,2-a]-pyrimidin-4-ones as Transcriptional Function Suppressors of Estrogen-related Receptor a (ERRα). Scientia Sinica Chimic. 2015, 45, 968-978.  14. Zufeng Guo,† Zhiqiang Cheng,† Jingxin Wang,† Wukun Liu, Hanjing Peng, Yuefan Wang, A.V. Subba Rao, Ruo-jing Li, Xue Ying, Preethi Korangath, Maria V. Liberti, Yingjun Li, Yongmei Xie, Sam Y. Hong, Cordelia Schiene-Fischer, Gunter Fischer, Jason W. Locasale, Saraswati Sukumar, Heng Zhu, and Jun O. Liu*; Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays. Angewandte Chemie International Edition. 2019, 58, 17158–17162. 申请专利： 1. 丁克, 彭丽洁, 段磊, 沈梦婕, 李迎君, 严佳杰, 用作蛋白聚糖酶调节剂的化合物及其应用：中国. CN102276546B. 2014-6-25. 2. 丁克, 常少华, 朱孝峰, 李迎君, 邓蓉, 5-噻唑酰胺类化合物及其生物学应用：中国. CN101921268A. 2010-8-27. 3. 丁克, 程辉敏, 李迎君, 谈理, 王雪聪, 张章, 庄晓曦, 龙活尤, 5-芳基酚-2-烷基取代并咪唑类化合物和应用：中国. 201410069823.X. 2014-2-27. 4. 丁克, 李迎君, 程辉敏, 任小梅, 张章, 庄晓曦, 龙活尤, 涂正超, 磺酰胺基芳基炔类化合物及其用途：中国. 201410753013.6. 2014-12-9. 5. Jun Liu, Yingjun Li, Kalyan Kumar, Wukun Liu, Wei Shi, Rojing Li, and Sarah Head. Itraconazole Analogs and Use Thereof. The United States Application Serial No.: 62/742,046. 2018-10-5. 加入团队 查看更多 联系我们 联系地址 广东省深圳市南山区学苑大道1088号创园5栋605 办公电话 0755-88018344 电子邮箱 liyj@sustech.edu.cn 内容来自集群智慧云企服 实用新型专利1875代写全部资料全国受理