顾宁科研成果

基本信息 科学研究 教育教学 论文专著 新建主栏目 基本信息 名称 顾宁，男，教授，博士生导师；哈尔滨工业大学生命科学与技术学院。 研究领域 名称 2010年1月，进入哈尔滨工业大学生命与工程系工作，主要从事有关药理学与内分泌疾病领域的研究. 现主要研究方向： 1. 糖尿病、肥胖症等内分泌疾病相关基因功能的研究 2. 环境污染物对健康影响及分子机制研究 3. 纳米粒子、小分子化合物的药理及毒理研究 现负责科研项目有： 1.【纳米材料对不同发育时期小鼠血糖代谢的影响及其机制的研究】 国家自然科学基金 2017-2020 负责人 2.【特定的转录因子重组蛋白质诱导成纤维细胞直接重编程为软骨细胞及其安全性的研究】 国家自然基金 2012-2016 负责人 3.【水环境中TiO2纳米颗粒对血糖代谢的影响极其机制的研究】 城市水资源与水环境国家重点实验室 2015-2016 负责人 4.【转录因子重组蛋白改善间充质干细胞增殖能力的研究】 黑龙江省归国留学基金 2012-2015 负责人 5.【水环境中的纳米粒子对内分泌系统的毒理效应及其机制的研究】 城市水资源与水环境国家重点实验室 2011-2014 负责人 6.【关于改善重组蛋白诱导iPS细胞效率的研究】 国家自然科学基金 2011-2011 负责人 工作经历 名称 2016.1-至今 哈尔滨工业大学 生命科学与技术学院 教授 2010.1-2015.12 哈尔滨工业大学 生命科学与技术学院 副教授 2009.4-2010.1 日本 产业技术综合研究所 研究员 2007.4-2009.3 日本 京都大学 学术振兴会（JSPS）研究员 教育经历 名称 2004.4-2007.3 日本　京都大学　　　 博士 2002.4-2004.3 日本　京都大学　　　 硕士 1998.4-2002.3 日本　京都教育大学　 学士 科研成果 名称 发表论文： 1. Du H, Li J, Wei X, Yang D, Zhang B, Fan X, Zhao M, Zhu R, Zhang Z, Zhang Y, Li X, Gu Ning*. Methylparaben induces hepatic glycolipid metabolism disorder by activating the IRE1α-XBP1 signaling pathway in male mice.Environ Int. 2024 Jan 19;184:108445. doi:10.1016/j.envint.2024.108445. 2. Zhang B, Fan X, Du H, Fan X, Zhao M, Zhang Z, Zhu, R, He B, Zhang Y, Li X, Li J, Gu Ning*. Foodborne carbon dot exposure induces insulin resistance through gut microbiota dysbiosis and damaged intestinal mucus layer. ACS Nano. 2023 Mar 28;17(6):6081-6094. doi: 10.1021/acsnano.3c01005. 3. Fan X, Li X, Jiaxin Li , Zhang Y Wei X, Hu H, Zhang B, Du H, Zhao M, Zhu R, Yang D, Oh Y, Gu Ning*. Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice. Journal of Environmental Sciences. Available online 2 March 2023 4. Yang D, Sun X, Wei X, Zhang B, Fan X, Du H, Zhu R, Oh Y, Gu Ning*. Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivation. Food and Chemical Toxicology. 2023 Feb;172:113563. doi: 10.1016/j.fct.2022.113563. 5. Wei X, Yang D, Zhang B, Fan X, Du H, Zhu R, Sun X, Zhao M, Gu Ning*.. Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice. Sci Total Environ. 2022 Oct 10;842:156815. doi: 10.1016/j.scitotenv.2022.156815. 6. Zhang B, Yu L, Zhu R, Wei X, Fan X, Hu H, Yang D, Du H, Zhao M, Li L, Oh Y, Feng Y, Gu Ning*. Malting barley carbon dots-mediated oxidative stress promotes insulin resistance in mice via NF-κB pathway and MAPK cascade. J Nanobiotechnology. 2022 Jul 16;20(1):331. doi: 10.1186/s12951-022-01543-1. 7. Yang D, Wei X, Zhang Z, Chen X, Zhu R, Oh Y, Gu Ning*. Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases. Chem Biol Interact. 2022 Aug 25;363:110027. doi: 10.1016/j.cbi.2022.110027. 8. Yang D, Wei X, Zhang B, Zhu R, Hu H, Fan X, Du H, Chen X, Zhang Z, Zhao M, Oh Y, Gu Ning*. Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolic disorder of mice via FXR signaling. Food Chem Toxicol. 2022 Nov;169:113440. doi: 10.1016/j.fct.2022.113440. 9. Guo Q, Zhang B, Du H, Zhu R, Sun X, Fan X, Wei X, Yang D, Oh Y, Fan L, Wang C, Gu Ning*. High-fat diet and palmitate inhibits FNDC5 expression via AMPK-Zfp57 pathway in mouse muscle cells. Chem Biol Interact. 2022 Nov 11:110265. doi: 10.1016/j.cbi.2022.110265. 10. Zhang B, Zhu R, Sun X, Guo Q, Zhang Y, Zhang N, Oh Y, Fan L, Wang C, Gu Ning*. Fatty acid palmitate suppresses FoxO1 expression via PERK and IRE1 unfolded protein response in C2C12 myotubes. Toxicol In Vitro. 2022 Aug 24;85:105459. doi: 10.1016/j.tiv.2022.105459. 11. Fan X, Wei X, Hu H, Zhang B, Yang D, Du H, Zhu R, Sun X, Oh Y, Gu Ning*. Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice. Chemosphere. 2022 Feb;288(Pt 3):132607. doi: 10.1016/j.chemosphere.2021.132607. 12. Daqian Yang, Xiaoting Zhang, Lei Yue, Hailong Hu, Xiangjuan Wei, Qian Guo, Boya Zhang, Xingpei Fan, Yuan Xin, Yuri Oh, Gu Ning*. Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression.Chemosphere, 2021, 273:129727. 13. Hailong Hu, Qian Guo, Xingpei Fan, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Gu Ning*. Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice. Nanotoxicology. 2020 Feb;14(1):59-76. 14. Hailong Hu, Boya Zhang, Li Li, Qian Guo, Daqain Yang, Xiangjuan Wei , Xingpei Fan, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Changlin Wang, Liping Hou, Gu Ning*. The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environ Toxicol. 2020 Apr;35(4):443-456. 15. Qian Guo, Hailong Hu, Xiaohuan Liu, DaQian Yang, Yao Yin, Boya Zhang, Hongjuan He, Yuri Oh, Qiong Wu, Chuanpeng Liu, Gu Ning*. C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1081-E1092. 16. Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Gu Ning*. Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species.Particle and Fibre Toxicology.2019, Vol.16:41. 17. Qian Guo，Hailong Hu，Ying Zhoua，Yuheng Yan，Xiangjuan Wei，Xingpei Fan，Daqian Yang，Hongjuan He，Yuri Oh，Kun Chen，Qiong Wu，Chuanpeng Liu，Gu Ning*. Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells. Food Chem Toxicol, 2019 March; 125: 95-105. 18. Hailong Hu, Xingpei Fan, Yao Yin, Qian Guo, Daqian Yang, Xiangjuan Wei, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Kun Chen, Yujie Feng, Liping Hou, Li Li, Gu Ning*. Mechanisms of titanium dioxide nanoparticle-induced oxidative stress and modulation of plasma glucose in mice. Environ Toxicol. 2019 Nov;34(11):1221-1235. 19. Qian Guo, Xiangjuan Wei, Hailong Hu, Daqian Yang, Boya Zhang, Xingpei Fan, Jing Liu, Hongjuan He, Yuli Oh, Qiong Wu, Yao Zhang, Chuanpeng Liu, Changlin Whang, Gu Ning*. The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes. Biochemical and Biophysical Research Communications. Vol. 520(3):619-626, 2019. 20. Hu Hailong, Li Li, Guo Qian, Zong He, Yan Yuheng, Yin Yao, Wang Yu, Oh, Yuri, Feng Yujie, Wu Qiong, Gu Ning*. RNA sequencing analysis shows that titaniumdioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 2018 May;12(4):341-356. 21. Guo Qian, Jin Sanli, Hu Hailong, Zhou Ying, Yan Yuheng, Zong He, Wang Yu, He Hongjuan, Oh Yuli, Liu Chuanpeng, Gu Ning*. Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response. Biochem Biophys Res Commun. 2017 Nov 4;493(1):346-351. 22. Hu Hailong, Li Li, Guo Qian, Jin Sanli, Zhou Ying, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning*. A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice. Food Chem Toxicol, 2016, 95:175-187. 23. Gu Ning, Hu Hailong, Guo Qian, Jin Sanlin, Wang Changlin, Oh Yuri, Feng Yujie, Wu Qiong, Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food Chem Toxicol, 2015, 86:124-131. 24. Gu Ning, Guo Qian, Mao Ke, Hu Hailong, Jin Sanlin, Zhou Ying, He Hongjuan, Oh Yuri, Liu Chuanpeng, Wu Qiong, Plasmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes. Biochem Biophys Res Commun, 2015, 467: 521-526. 25. Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning. Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. J. App. Toxicol. 2015. 26. Hu Hailong, Li Li, Wang Changlin, He Hongjuan, Mao Ke, Ma Xiao, Shi Ruoyu, Oh Yuri, Zhang Fengwei, Lu Ying, Wu Qiong, Gu Ning. 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33(6):1899-910. 27. Wang CL, Diao YX, Xiang Q, Ren YK, Gu Ning. Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. Eur J Pharmacol. 2014 Sep 5;738:1-7. 28. Wang CL, Xiang Q, Diao YX, Ren YK, Gu Ning. Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. Eur J Pain. 2014 Sep;18(8):1157-64. 29. Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. Diabetes Technol. Ther. 12(2):125-133, Feb, 2010. 30. Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. Clin Exp Pharm Phys. 35(12), 1433-1439, May, 2008. 31. Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Ya 32. suda Koichiro, Tsuda Kinsuke. HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. Biochem Biophys Res Commun. 353(3), 617-622, Feb, 2007. 33. Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 346(3), 1016-1023, Aug, 2006. 34. Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells. J Nutrl Sci Vitaminol. 52(2), 105-112, Apr, 2006. 35. Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cells. Biochem Biophys Res Commun. 325(1), 308-313, Oct, 2004. 授权专利 名称 1) 顾宁, 胡海龙, 毛轲, 郭倩. 一种促进肌肉细胞中GLUT4基因表达的方法: ZL2014 10076511.1. 2016-09-07. 2) 顾宁, 岳磊，胡海龙, 郭倩, 毛轲. SB505124在制备治疗软骨损伤的药物中的应用: ZL2014 10200906.8. 2016-01-27. 3) 顾宁, 岳磊, 胡海龙. 一种提高人间充质干细胞分化能力的方法: ZL2014 10264739.3. 2016-08-24. 4) 顾宁, 马卓, 胡海龙, 郭倩. 一种检测脏器组织中是否存在纳米颗粒的方法: ZL2014 10465607.7. 2017-01-04. 科研项目 项目名称 【特定的转录因子重组蛋白质诱导成纤维细胞直接重编程为软骨细胞及其安全性的研究】 项目来源 国家自然基金 开始时间 2012-01-01 结束时间 2016-01-01 项目经费 担任角色 负责 项目类别 横向项目 项目状态 完成 简单介绍 项目名称 【转录因子重组蛋白改善间充质干细胞增殖能力的研究】 项目来源 黑龙江省归国留学基金 开始时间 2012-01-01 结束时间 2015-01-01 项目经费 担任角色 负责 项目类别 横向项目 项目状态 完成 简单介绍 项目名称 【水环境中的纳米粒子对内分泌系统的毒理效应及其机制的研究】 项目来源 城市水资源与水环境国家重点实验室 开始时间 2011-01-01 结束时间 2014-01-01 项目经费 担任角色 负责 项目类别 横向项目 项目状态 完成 简单介绍 项目名称 【关于改善重组蛋白诱导iPS细胞效率的研究】 项目来源 国家自然科学基金 开始时间 2011-01-01 结束时间 2011-01-01 项目经费 担任角色 负责 项目类别 横向项目 项目状态 完成 简单介绍 项目名称 纳米材料对不同发育时期小鼠血糖代谢的影响及其机制的研究 项目来源 国家自然科学基金 开始时间 2017 结束时间 2020 项目经费 担任角色 负责 项目类别 纵向项目 项目状态 进行中 简单介绍 项目名称 水环境中 TiO2纳米颗粒对血糖代谢的影响极其机制的研究 项目来源 城市水资源与水环境国家重点实验室 开始时间 2015.01.01 结束时间 2016.12.30 项目经费 担任角色 负责 项目类别 纵向项目 项目状态 进行中 简单介绍 研究领域 名称 干细胞的增殖与分化机制、体细胞重编程等研究 糖尿病，肥胖症等内分泌疾病的发病机制和治疗方法的研究 纳米粒子及小分子化合物的药理研究 团队成员 名称 胡海龙：博士, 研究方向: 纳米毒理与内分泌系统疾病.郭 倩：博士, 研究方向: UPR信号通路参与棕榈酸诱导的musclin基因表达的初步研究. 周 莹：硕士, 研究方向: 葡萄糖胺调控Musclin、CTRP15及FNDC5基因表达及机制的初步研究 闫玉恒：硕士, 研究方向: 糖尿病机制研究. 宗 贺：硕士, 研究方向: 糖尿病机制研究. 讲授课程 名称 《生物制品》 研究生学位课，了解生物制品的制备方法和基本要求，掌握生物制品制备的基本原理及制备技术，了解生物制品领域的最新进展及发展趋势。 《生命科学基础与应用》 校管核心课课，旨在扩大学生的知识面，培养学生生命科学的思维方式，将生命科学的思想、方法运用到他们所从事的工作领域。 《纳米技术与基因研究》 新生研讨课，以纳米技术在基因领域的研究为重点，讲授纳米技术在基因靶向医疗、基因检测诊断等领域的最新研究进展，与同学们共同分析存在的科学问题及解决方法，探讨纳米技术在生命医学领域的未来发展方向与前景。 招生信息 名称 招收硕士：1-2名 招收博士：1名 论文期刊 论文标题 Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. 作者 Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. 发表时间 期刊名称 Diabetes Technol 期卷 12(2):125- 简单介绍 论文标题 Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. 作者 Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. 发表时间 期刊名称 Clin Exp Pharm Phys 期卷 35(12), 14 简单介绍 论文标题 HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. 作者 Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. 发表时间 期刊名称 Biochem Biophys Res Commun. 期卷 353(3), 61 简单介绍 论文标题 Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. 作者 Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. 发表时间 期刊名称 Biochem Biophys Res Commun. 期卷 346(3), 10 简单介绍 论文标题 Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 作者 Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. 发表时间 期刊名称 J Nutrl Sci Vitaminol 期卷 52(2), 105 简单介绍 论文标题 Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cel 作者 Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. 发表时间 期刊名称 Biochem Biophys Res Commun 期卷 325(1), 30 简单介绍 论文标题 4-PBA Increases GLUT4 Gene Expression through Suppression of HDAC5 作者 Hailong Hu, Li Li, Changlin Wang, Hongjuan He, Ke Mao, Xiao Ma, Ruoyu Shi, Yuri Oh, FengWei Zhang, Ying Lu, Qiong Wu, Ning Gu 发表时间 期刊名称 Cell Physiol Biochem 期卷 2014;33:18 简单介绍 论文标题 Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. 作者 Wang CL, Diao YX, Xiang Q, Ren YK, Gu N. 发表时间 期刊名称 Eur J Pharmacol 期卷 2014 Sep 5 简单介绍 论文标题 Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. 作者 Wang CL, Xiang Q, Diao YX, Ren YK, Gu N. 发表时间 期刊名称 Eur J Pain. 期卷 2014 Sep;1 简单介绍 论文标题 Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. 作者 Wang CL, Ren YK, Xiang Q, Wang Y, Gu N, Lu C, Wang R. 发表时间 期刊名称 Neuropeptides 期卷 2013 Oct;4 简单介绍 论文标题 Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. 作者 Gu Tiantian, He Hongjuan, Xing Yanjiang, Liu Qi, Gu Ning, Sugimoto Kenkichi, Jiang Huijie and Wu Qiong. 发表时间 期刊名称 J Mol Histol. 期卷 简单介绍 论文标题 Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cart 作者 Ikegami Dasuke, Iwai T, Ryo Senyi, Gu Ning, Sugiyama Tasuke, Oh Isamu, Yoshikawa Hiroyuki, Tsumaki Nobuyuki. 发表时间 期刊名称 Osteoarthritis Cartilage. 期卷 19(2), 233 简单介绍 论文标题 Characteristics of skeletal muscle in rats with diabetes, hypertension, obesity,and hyperlipidemia. 作者 Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. 发表时间 期刊名称 J Atheroscler Thromb 期卷 16(5), 576 简单介绍 论文标题 Effects of hyperbaric exposure with high oxygen concentration on reactive oxygen metabolites in type II collagen-induced arthri 作者 Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Okiur Tomonori, Morimatsu Fumiki, Takeda Isao, Ishihara Akihiko. 发表时间 期刊名称 Free Radical Research 期卷 简单介绍 论文标题 Association of UCP2 and UCP3 polymorphisms with autonomic nervous system functionin young Japanese males. 作者 Matsunaga Tetsuro, Gu Ning, Yamazaki Hanae, Tsuda Mariko, Adachi Tetsuya, Yasuda ,Koichiro, Moritani, Toshio, Tsuda Kinsuke, Non 发表时间 期刊名称 J Hypertens. 期卷 27(2), 30 简单介绍 论文标题 Bone density of the femur and fFiber cross-sectional area and oxidative enzyme activity of the tibialis anterior muscle in type 作者 Okiura Tomonori, Nagatomo Fumiko, Gu Ning, Taguchi Yasuki, Morimatsu Fumiki and Ishihara Akihiko. 发表时间 期刊名称 J Physiol Sci. 期卷 58(4), 221 简单介绍 论文标题 ZFAT expression in B and T lymphocytes andidentification of ZFAT-regulated genes. 作者 Koyanagi Midori, Nakabayashi Kazuhiko, Fujimoto Takahiro, Gu Ning, Baba Iwai, Sasazuki Takehiko and Shirasawa Senji. 发表时间 期刊名称 Genomics. 期卷 91(5), 451 简单介绍 论文标题 Effects of hyperbaric exposure with high oxygenconcentration on glucose and insulin levels and skeletal muscle fiber properties 作者 Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Matsumoto Akiko, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko. 发表时间 期刊名称 Muscle Nerve 期卷 35(3), 337 简单介绍 论文标题 Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. 作者 Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. 发表时间 期刊名称 Am Heart J. 期卷 154(4), 75 简单介绍 论文标题 Fiber type distribution, succinate dehydrogenese and peroxisome proliferator- activatedreceptor gamma coactivator- 1alpha gene e 作者 Adachi Tetsuya, Kikuchi Naoko, Yasuda Koichiro, Anahara Reko, Gu Ning, Matsunaga Tetsuro, Yamamura Tsubasa, Tsujimoto Gozou, Ts 发表时间 期刊名称 Exp Physiol. 期卷 92(2), 449 简单介绍 论文标题 Hyperbaric exposure with high oxygen concentration inhibits growth-associated increase in the glucose level of diabetic Goto-Ka 作者 Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Tsuda Kinsuke, Kikuchi Naoko, Matsunaga Tetsuro, Ishihara Akihiko. 发表时间 期刊名称 Diabetes Obes Metab. 期卷 8(6), 714- 简单介绍 论文标题 Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. 作者 Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. 发表时间 期刊名称 J Hum Genet 期卷 52(1), 28- 简单介绍 论文标题 Association of C825T Polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy japanese individ 作者 Matsunaga Tetsuro, Nagasumi Kae, Gu Ning, Nishikino Mariko, Ueda Yukihiko, Moritani Toshio, Aoki Norihiko, Tsuda Kinsuke, Yasuda 发表时间 期刊名称 Am J Hypertens. 期卷 18(4), 523 简单介绍 论文标题 T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects. 作者 Yasuda Koichiro, Matsunaga Tetsuro, Moritani Toshio, Nishikino Mariko, Gu Ning, Yoshinaga Mariko, Nagasumi Kae, Yamamura Tsubas 发表时间 期刊名称 Clin Exp Pharm Phys 期卷 31(9), 597 简单介绍 论文标题 Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice 作者 Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, 发表时间 期刊名称 J. App. Toxicol. 期卷 简单介绍 论文标题 Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice 作者 Gu N, Hu H, Guo Q, Jin S, Wang C, Oh Y, Feng Y, Wu Q 发表时间 期刊名称 Food Chem Toxicol 期卷 86:124-31 简单介绍 论文标题 Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes 作者 Gu N, Guo Q, Mao K, Hu H, Jin S, Zhou Y, He H, Oh Y, Liu C, Wu Q 发表时间 期刊名称 Biochem Biophys Res Commun 期卷 467(3):521-6 简单介绍 论文标题 A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice 作者 Hailong Hu, Li Li, Qian Guo, Sanli Jin, Ying Zhou, Yuri Oh, Yujie Feng, Qiong Wu, Ning Gu* 发表时间 期刊名称 Food Chem Toxicol 期卷 95:175-187 简单介绍 专利 名称 1) 顾宁, 胡海龙, 毛轲, 郭倩. 一种促进肌肉细胞中GLUT4基因表达的方法: 中国, CN103820384A. 2014-05-28. 2) 顾宁, 胡海龙, 郭倩, 毛轲. SB505124在制备治疗软骨损伤的药物中的应用: 中国, CN103961352A. 2014-08-06. 3) 顾宁, 岳磊, 胡海龙. 一种提高人间充质干细胞分化能力的方法: 中国, CN104004711A. 2014-08-27. 4) 顾宁, 马卓, 胡海龙, 郭倩. 一种新的检测组织中纳米颗粒的方法: 中国, CN104198510A. 2014-12-10.