杨奎琨科研成果

Research Principal Investigator Publications Positions Members 新建主栏目 Research Interest 名称 Our research group focuses on the design, synthesis and biomedical applications of self-assembled nanomaterials. We are particularly interested in the construction of self-assembled nanomedicines for cancer diagnosis and therapy. Our current major projects include: 1) development of polyprodrug nanoassemblies for cancer immunotherapy and 2) construction of hybrid polymer-inorganic nanoassemblies for cancer treatment. Polyprodrug-based nanomedicine Hybrid polymer-inorganic nanoassembly Introduction 名称 Kuikun Yang received his Doctoral Degree of Chemistry from University of Maryland, College Park in 2018 under the supervision of Prof. Zhihong Nie. In 2019, He joined NIH and University of Macau as a postdoctoral researcher under the joint supervision of Prof. Xiaoyuan Chen and Prof. Ruibing Wang. He joined the School of Life Science and Technology in Harbin Institute of Technology in 2021 as a professor. His current research interests focus on the assembly of nanomaterials for the imaging, diagnosis and therapy of tumors. He has published a series of works in Journal of the American Chemical Society, Angewandte Chemie International Edition, Advanced Materials, Chemical Society Reviews, ACS Nano, Advanced Functional Materials, Nano Today and Biomaterials as the first author. Kuikun Yang has been selected as the member of Early Career Researcher Board of Materials Today Bio (IF: 10.761), Military Medical Research (IF: 34.915), Journal of Materials Science and Technology (IF: 10.32) and Asian Journal of Pharmaceutical Sciences (IF: 9.289). He is also a reviewer editor of Frontiers in Chemistry (IF:5.545). Education 标题 起讫时间 2013.9-2018.12 所学专业 Chemistry 学习机构 University of Maryland, College Park 学历 Ph.D. 简单介绍 标题 起讫时间 2010.9-2013.6 所学专业 Biochemistry and Molecular Biology 学习机构 Ocean University of China 学历 MSc Degree 简单介绍 标题 起讫时间 2006.9-2010.6 所学专业 Biotechnology 学习机构 Ocean University of China 学历 BSc Degree 简单介绍 Work Experience 标题 起讫时间 2020.2-2021.5 职位/职称 Postdoctoral Fellow 工作单位 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau 简单介绍 标题 起讫时间 2019.3-2020.2 职位/职称 Postdoctoral Fellow 工作单位 National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health 简单介绍 论文期刊 title Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines author Kaisheng You, Qi Wang, Mohamed Syazwan Osman, Dongpyo Kim, Qian Li,* Chao Feng,* Lei Wang,* Kuikun Yang* release time 2024.1 periodical name BMEMat phase volume introduction title Neutrophil Membrane-Camouflaged Polyprodrug Nanomedicine for Inflammation Suppression in Ischemic Stroke Therapy author Ya Zhao,# Qian Li,#,* Jingyan Niu, Erliang Guo, Chenchen Zhao, Jian Zhang, Xue Liu, Lihua Wang, Lang Rao,* Xiaoyuan Chen,* Kuikun Yang* release time 2024.3 periodical name Advanced Materials phase volume introduction 论文标题 Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery 作者 Kuikun Yang,# Yijing Liu,# Yi Liu, Qian Zhang, Chuncai Kong, Chenglin Yi, Zijian Zhou, Zhantong Wang, Guofeng Zhang, Yang Zhang, Niveen M. Khashab,* Xiaoyuan Chen* and Zhihong Nie* 发表时间 2018.3 期刊名称 Journal of the American Chemical Society 期卷 140: 4666 简单介绍 论文标题 Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumour 作者 Kuikun Yang,# Guocan Yu,# Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen* and Ruibing Wang* 发表时间 2021.8 期刊名称 Angewandte Chemie International Edition 期卷 60: 17570 简单介绍 论文标题 Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy 作者 Kuikun Yang,# Guocan Yu,# Rui Tian, Zijian Zhou, Hongzhang Deng*, Ling Li, Zhen Yang, Guofeng Zhang, Dahai Liu, Jianwen Wei, Ludan Yue, Ruibing Wang* and Xiaoyuan Chen* 发表时间 2021.3 期刊名称 Advanced Functional Materials 期卷 31: 2008078 简单介绍 论文标题 A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy 作者 Kuikun Yang,# Ludan Yue,# Guocan Yu, Lang Rao, Rui Tian, Jianwen Wei, Zhiqing Yang,# Chen Sun, Xiangjun Zhang, Mengze Xu, Zhen Yuan, Xiaoyuan Chen* and Ruibing Wang* 发表时间 2021.8 期刊名称 Biomaterials 期卷 275: 120822 简单介绍 论文标题 Enzyme-induced in vivo assembly of gold nanoparticles for imaging-guided synergistic chemo-photothermal therapy of tumor 作者 Kuikun Yang,# Yijing Liu,# Yin Wang,# Qilong Ren, Hongyu Guo, John B. Matson, Xiaoyuan Chen* and Zhihong Nie* 发表时间 2019.12 期刊名称 Biomaterials 期卷 223: 119460 简单介绍 论文标题 Polymers and Inorganic Nanoparticles: A Winning Combination towards Assembled Nanostructures for Cancer Imaging and Therapy 作者 Kuikun Yang,# Shaoyi Zhang,# Jie He and Zhihong Nie* 发表时间 2021.2 期刊名称 Nano Today 期卷 36: 101046 简单介绍 论文标题 Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy 作者 Kuikun Yang,# Zhiqing Yang,# Guocan Yu*, Ruibing Wang* and Xiaoyuan Chen* 发表时间 2021.10 期刊名称 Advanced Materials 期卷 In press 简单介绍 论文标题 An Enzyme-Free Signal Amplification Technique for Ultrasensitive Colorimetric Assay of Disease Biomarkers 作者 Haihang Ye,# Kuikun Yang,# Jing Tao, Yijing Liu, Qian Zhang, Sanaz Habibi, Zhihong Nie* and Xiaohu Xia* 发表时间 2017.2 期刊名称 ACS Nano 期卷 11: 2052 简单介绍 论文标题 Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics 作者 Qilong Ren,# Kuikun Yang,# Rujia Zou, Zhiping Wan, Zheyu Shen, Guangyu Wu, Zijian Zhou, Qianqian Ni, Wenpei Fan, Junqing Hu* and Yijing Liu* 发表时间 2019.11 期刊名称 Nanoscale 期卷 11: 23021 简单介绍 论文标题 Engineering heterogeneity of precision nanoparticles for biomedical delivery and therapy 作者 Di Zheng,# Kuikun Yang# and Zhihong Nie* 发表时间 2021.5 期刊名称 View 期卷 20200067 简单介绍 Graduate Students and Research Assistants 名称 We current have multiple openings to highly self-motivated MSc, Ph.D students and research assistants who are interested in polymer synthesis, nanoparticle synthesis, self-assembly, nanomedicine or cancer theranostics. Interested individuals should forward a CV to Prof. Yang at yangkuikun@hit.edu.cn Postdoctoral Positions 名称 We are seeking for postdoctoral fellows who are interested in polymer synthesis, nanoparticle synthesis, self-assembly, nanomedicine or cancer theranostics. Researches with experience in polymer/nanoparticle synthesis, biosensing and cancer immunotherapy are particularly welcome to join our group. We will provide attractive salary and benefits (including accommodation and education) to ensure a nice platform for high-quality research. Detailed information could be found via the link below. Interested individuals should forward a CV including publication list to Prof. Yang at yangkuikun@hit.edu.cn 友情链接 链接名称 Details of Postdoctoral Positions 链接地址 https://mp.weixin.qq.com/s/G-WrL6S_5LXhRte0zSGNFg 简单介绍 Sincerely look forward to your joining us ! Graduate Students 名称