游常军科研成果

基本信息     游常军，湖南大学化学化工学院、化学生物传感与计量学国家重点实验室教授、博士生导师。主讲《化学生物学》、《波谱分析》、《仪器分析实验》等研究生与本科生课程，作为编委和主编之一分别编写了普通高等教育“十一五”国家级规划教材《分析化学》和国家级线上一流本科课程配套教材《波谱分析》。主要从事生物分析化学、化学生物学与分子医学等多学科交叉领域的研究，利用生物质谱以及相关的化学生物学新工具，研究核酸化学修饰在遗传信息传递过程中的生物学效应及调控机制，从分子水平上探讨癌症等疾病发生发展及耐药的机制，为疾病诊疗和新药研发提供理论和技术基础。目前已在Anal. Chem., Acc. Chem. Res., Nat. Chem. Biol., Nat. Protoc., Nucleic Acids Res., PNAS等学术期刊发表论文40余篇。   Dr. Changjun You is currently a Professor in the College of Chemistry and Chemical Engineering at Hunan University. He received his Ph.D. in Biochemistry and Molecular Biology from Huazhong Agricultural University, and he conducted postdoctoral research in the Department of Chemistry at the University of California-Riverside. His research interests span a wide range of topics in bioanalytical chemistry, chemical biology,  molecular medicine, and molecular toxicology. Specially, he has made significant progress in developing the mass spectrometry-based quantitative strategies for assessing the cytotoxic, mutagenic and carcinogenic potentials of chemically modified biomacromolecules that can be induced by various endogenous and environmental genotoxic agents. To date, he has published more than 40 research articles in highly reputed international journals such as Analytical Chemistry, Accounts of Chemical Research, Nature Chemical Biology, Nature Protocols and Nucleic Acids Research.   Email: changjun@hnu.edu.cn   Selected Publications Zheng, X., Chang, S,. Liu, Y,. Dai, X*., You, C.* Human mitochondrial protein HSPD1 binds to and regulates the repair of deoxyinosine in DNA. Journal of Proteome Research, 2023, 22: 1339-1346. Zheng, X., Chen, D., Zhao, Y., Dai, X*., You, C.* Development of an endonuclease V-assisted analytical method for sequencing analysis of deoxyinosine in DNA. Analytical Chemistry, 2022, 94: 11627-11632. Yang, Y., Wang, Z,. Wang, J,. Dai, X*., You, C.* Next-generation sequencing-based analysis of the effects of N1- and N6-methyldeoxyadenosine adducts on DNA transcription. Analytical Chemistry, 2022, 94: 11248-11254. Liu, Y., Zhu, X,. Wang, Z,. Dai, X*., You, C.* Next-generation sequencing-based analysis of the roles of DNA polymerases ν and θ in the replicative bypass of 8-oxo-7,8-dihydroguanine in human cells. ACS Chemical Biology, 2022, 17: 2315-2319. Liu, Y., Qu, M,. Pan, M., Zheng, X., Sheng, Y., Ji, Y., You, C*., Dai, X.* Chemical proteomic profiling of UTP-binding proteins in human cells.Analytica Chimica Acta, 2021, 1168: 338607. Kong, W., Wang, L., Zhao, Y., Chen, H., Liu, Y., Han, X., Yang, Y., Wang, J., You, C*., Liu, Y*. Sequential module coordination-driven programmable function switch of metal-molecule nanoframeworks for cancer theranostics. Nano Today 2021, 38: 101126. You, C., Dai, X., Wang, Y*. Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation. Nucleic Acids Research, 2017, 45: 9059-9067. You, C., Wang, Y*. Mass spectrometry-based quantitative strategies for assessing the biological consequences and repair of DNA adducts. Accounts of Chemical Research, 2016, 49: 205-213. You, C., Wang, Y*. Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specific DNA lesions in vitro and in vivo. Nature Protocols, 2015, 10: 1389-1406. You, C., Dai, X., Yuan, B., Wang, J., Wang, J., Brooks, P., Niedernhofer, L., Wang, Y*. A quantitative assay for assessing the effects of DNA lesions on transcription. Nature Chemical Biology, 2012, 8, 817-822.

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