刘琦科研成果

个人简介 刘琦，男，博士，副教授，硕士研究生导师。2015年6月于中南大学分析化学专业博士毕业，获理学博士学位；2015年11月至2017年12月在中国科学院上海应用物理研究所从事博士后研究；2018年4月至今在中南大学化学化工学院任教。主要从事生物复杂体系分离分析、疾病早期诊断、环境与食品安全智能检测及纳米DNA生物传感器等方面的研究。主持国家自然科学基金青年项目、中南大学创新驱动、湖南省自然科学青年/面上基金项目、中国博士后科学基金项目等，以第一作者或通讯作者在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., Food Chem.等国际权威刊物上发表SCI收录论文60余篇，引用2300+次，H-index=26，授权国家发明专利5项，2019年获湖南省自然科学二等奖1项(排名第3)。发表论文：2024： [1] An Endogenous mRNA-powered and Spatial Confinement-derived DNA Nanomachine for Ultra-rapid and Sensitive Imaging of Let-7a, Anal. Chem., 2024, 96, 564-571 [2] Au/Pt@ZIF-90 Nanoenzyme Capsule based “Explosive” Signal Amplifier for "All-in-Tube" POCT, Anal.Chem., 2024, 96, 1362-1370 [3] Hydrogen bonding-induced aggregation of chiral functionalized AuNS@Ag NPs for photothermal enantioanalysis, Anal.Chem., 2024, doi.org/10.1021/acs.analchem.3c05751 [4] Photothermal hydrogel-integrated paper-based point-of-care platform for visible distance-readout of glucose, Anal. Chim. Acta, 2024, 1285, 342035 [5] A novel functionalized CdTe@MOFs based fluorometric and colorimetric biosensor for dual-readout assay of creatinine, Sensor Actuat. B-Chem., 2024, 399, 134842 [6] A luminescent MOF-based nonenzymatic probe for colorimetric photothermal fluorescence triple-mode assay of uric acid in body fluids, Talanta, 2024, 267, 125201 [7] Nitrogen, sulfur-doped carbon quantum dots with large Stokes shift for real-time monitoring of pH in living cells, Talanta, 2024, 267, 125479 [8] A novel laccase-like Cu-MOF for colorimetric differentiation and detection of phenolic compounds, Talanta, 2024, 272, 125840 [9] Intra-nanoparticle plasmonic nanogap based spatial-confinement SERS analysis of polypeptides, Talanta, 2024, 273, 125899 2023： [1] Pore Size Tunable Trypsin@ZIF-90 and Hydrogel Integrated Lateral Flow Point-of-Care Platform for ATP Detection, ACS Appl. Mater. Interfaces, 2023, 15, 17, 21690–21698 [2] Self-propelled quantum dots-based spherical nucleic amplifier for ratiometric imaging of intracellular microRNAs, Sensor. Actuat. B-Chem., 2023, 374, 132802 [3] Cu2+ assisted carnation-like fluorescent metal–organic framework for triple-mode detection of glyphosate in food samples, Food Chem., 2023, 408, 135237 [4] Dual-ligand lanthanide metal-organic framework probe for ratiometric fluorescence detection of mercury ions in wastewater, Microchim. Act, 2023, 190(9), 1-11 2022： [1] Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells, Anal. Chem., 2022, 94(6), 2934-2941 [2] Facile construction of a reusable multi-enzyme cascade bioreactor for effective fluorescence discrimination and quantitation of amino acid enantiomers, Chem. Eng. J., 2022, 428, 131975 2021： [1] AIEgen modulated per-functionalized flower-like IRMOF-3 frameworks with tunable light emission and excellent sensing properties, Chem. Commun., 2021, 57, 2392-2395 [2] Framework nucleic acid programmed combinatorial delivery nanocarriers for parallel and multiplexed analysis, Chem. Commun., 2021, 57, 10935-10938 [3] Integrating amino acid oxidase with photoresponsive probe A fast quantitative readout platform of amino acid enantiomers, Talanta, 2021, 224, 121894  [4] High quantum-yield carbon dots embedded metal-organic frameworks for selective and sensitive detection of dopamine, Microchem. J., 2021, 160, 105718 [5] Simultaneous In Situ Extraction and Self-Assembly of Plasmonic Colloidal Gold Superparticles for SERS Detection of Organochlorine Pesticides in Water, Anal. Chem.,  2021, 93(10), 4657-4665 2020: [1] Integrating Target-Triggered Aptamer Capped HRP@Metal−Organic Frameworks with Colorimeter Readout for On-site Sensitive Detection of Antibiotics, Anal. Chem., 2020, 92(20), 14259-14266. [2] AIE-active metal–organic frameworks facile preparation, tunable light emission, ultrasensitive sensing of copper(II) and visual fluorescence detection of glucose, J. Mater. Chem. C, 2020, 8(30), 10408-10415. [3] L-Pyroglutamic Acid-Modified CdSe/ZnS Quantum Dots: A New Fluorescence-Responsive Chiral Sensing Platform for Stereospecific Molecular Recognition, Anal. Chem., 2020, 92(17), 12040-12048. 2019-: [1] Valency-Controlled Framework Nucleic Acid Signal Amplifiers, Angew. Chem. Int. Ed., 2018, 57, 7131-7135 [2] Facile green and one-pot synthesis of purple perilla derived carbon quantum, Talanta, 2019, 201, 1-8 [3] Single-stranded DNA modified protonated graphitic carbon nitride nanosheets A versatile ratiometric fluorescence platform for multiplex detection of various targets, Talanta, 2019, 197, 422-430 科技奖励： [1] 2019年湖南省自然科学奖二等奖：食源生物小分子分离分析及构效关系研究 (排名第3) 主持科研项目：[1] 国家自然科学基金青年项目，基于功能化高阶框架核酸的前列腺肿瘤多标志物联合检测研究[2] 中国博士后科学基金第60批面上资助，DNA 纳米结构及其复合物的构建、纯化及生物检测应用[3] 湖南省自然科学基金青年项目，基于CCC-LC 全二维色谱的β-分泌酶抑制剂快速识别研究 [4] 中南大学创新驱动项目，基于框架化学的传感设计与应用 [5] 湖南省自然科学基金面上项目，基于框架核酸靶向功能纳米探针的前列腺癌诊疗一体化研究 [6] 中南大学科学研究启动基金，联用色谱体系构建及应用 [7] 食品安全监测与预警湖南省重点实验室2020年度开放基金课题 招生专业：分析化学、生物与医药 教育经历 [1]   2009.9-2015.5 中南大学  |  分析化学  |  博士学位  |  博士研究生毕业 硕博连读 [2]   2005.9-2009.6 中南大学  |  制药工程  |  学士学位  |  大学本科毕业 工作经历 [1]   2020.9-至今 中南大学  |  副教授  |  在岗 [2]   2018.4-2020.9 中南大学  |  化学化工学院  |  讲师 [3]   2015.11-2017.12 中国科学院上海应用物理研究所  |  助理研究员 研究方向 [1]  DNA纳米技术及疾病靶标传感检测：Angew. Chem. Int. Ed. 2018, 57, 7131-7135. Talanta 2019, 197, 422-430 [2]  天然及手性药物的分离分析：Food Chem. 2015, 186, 139-145. J. Chromatogr. A 2014, 1363, 236-241. [3]  色谱联用体系的构建与应用：J. Chromatogr. A 2014, 1364, 204-213. J. Sep. Sci. 2019, 42, 1194-1201 其他联系方式 [1]  邮箱： iliuqi@csu.edu.cn [4]  通讯/办公地址： 新校区化学楼343

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