武双婵科研成果

个人经历 personal experience 工作经历 教育经历 明尼苏达大学-双城分校    博士后           2016年8月—2020年11月西北工业大学          副教授         2021年4月-- 本科      武汉大学药学院            2007年9月--2011年6月 博士      武汉大学药学院            2011年9月--2016年6月

教育教学

教育教学 Education and teaching 教育教学 招生信息 药理学，神经生物学 欢迎广大药学、基础医学、生物化学及分子生物学背景的学子加入本课题组！ 内容来自集群智慧云企服 软件产品登记测试全国受理

荣誉获奖

科学研究 Scientific Research 本课题组聚焦髓鞘形成细胞少突胶质细胞（中枢神经系统）和施旺细胞（外周神经系统）在神经损伤、神经退行性疾病下的功能变化，寻找有效的干预靶点。主持承担科研项目：中央高校基本科研业务费:基于PERK-eIF2α信号通路研究miR211对小鼠外周神经损伤的保护作用，G2021KY05104，2021年1月-2022年12月。广东省区域联合基金:基于PERK-eIF2α信号通路研究miR211对小鼠脑卒中白质损伤的保护作用,2021A1515110801，2021年10月-2024年9月。陕西省自然科学基金青年项目:基于施旺细胞非折叠蛋白反应研究Salubrinal对周围神经损伤的修复作用，2022JQ-910，2022年1月-2023年12月。国家自然科学基金青年项目，少突胶质细胞eIF2α磷酸化介导脑缺血后血管再生的作用及机制，2023-01至2025-12。 内容来自集群智慧云企服

科学研究

学术成果 Academic Achievements 论文：1. Yulian Yang, Zhongzheng He, Shuangchan Wu. Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPARγ activation. Toxicol Appl Pharmacol. 2024, 2:484:116883.2. Wu Shuangchan, Wensheng Lin, The physiological role of the unfolded protein response in the nervous system. Neural Regen Res. 2024 (on line)3. Wu Shuangchan, Wensheng Lin, Endoplasmic reticulum associated degradation is essential for maintaining the viability or function of mature myelinating cells in adults. Glia. 2023,71(5):1360-1376.4. Wu Shuangchan, Sarrabeth Stone，Yue Yue, Wensheng Lin, Endoplasmic reticulum associated degradation is required for maintaining the viability and function of adult mature Schwann cells. Glia. 2021, 69(2): 489-506. 5. Wu Shuangchan, Sarrabeth Stone，Klaus-Armin Nave and Wensheng Lin. The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation. Journal of Neuroscience. 2020, 40(43): 8214-8232. 6.   Sarrabeth Stone，Wu Shuangchan (co-first)., Klaus-Armin Nave and Wensheng Lin. The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP. JCI insight. 2020, 5(5): e132364. 7.   Wu Shuangchan, Yue Yue, A. Peng, L. Zhang, X. Cao, J. Xiang, S. Yin and D. Hong. Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats. Food & function. 2016, 7(6): 2624-2634. 8.   Wu Shuangchan, Yue Yue,  Jian Li, Zhike Li, Xiaofei Li, Yunhui Niu, Jin Xiang，Hong Ding.   Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in rats against cerebral ischemia. Molecular nutrition & food research. 2015, 59(10): 1930-1941. 9.   Yue Yue,  Wu Shuangchan (co-first), Zhike Li, Jian Li, Xiaofei Li, Jin Xiang, Hong Ding.  Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enhanced intestinal barrier function. Food and function. 2015, 6(8): 2568-2577. 10. Wu Shuangchan, Yue Y, Hui Tian, Li Tao, Yuting Wang, Jin Xiang, Shi Wang,  Hong Ding. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS[J]. Neuropharmacology. 2014, 83: 107-117. 11. Wu Shuangchan, Yue Y, Hui Tian, Zhike Li, Xiaofei Li, Wei He, Hong Ding. Carthamus red from CarthamustinctoriusL. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway[J]. Journal of ethnopharmacology. 2013, 148(2)：570–578. 12. Lei Zhixin, Yue Yuan, Sarrabeth Stone, Wu Shuangchan; Wensheng Lin. NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE[J]. Journal of Neuroscience. 2020, 40(33): 6444-6456.13. Sarrabeth Stone, Yue Yuan, Milos Stanojlovic, Wu Shuangchan, Gerard Karsenty,Wensheng Lin. Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis[J]. JCI Insight. 2019, 4(2): e124232-e124232.14. Sarrabeth Stone, Wu Shuangchan, Stephanie Jamison, Wilaiwan Durose, Jean Pierre Pallais, Wensheng Lin. Activating transcription factor 6α deficiency exacerbates oligodendrocyte death and myelin damage in immune‐mediated demyelinating diseases. Glia. 2018, 66(7): 1331-1345.15. Tong Tao, Niu Yun-Hui, Yue Yuan, Wu Shuangchan, Ding Hong. Beneficial effects of anthocyanins from red cabbage (Brassica oleracea L. var. capitata L.) administration to prevent irinotecan-induced mucositis. Journal of Functional Foods. 2017, 32, 9-17. 16. Lu Yuzhi, Wu Shuangchan, Yuan Yue, Si He, Jun Li, Jun Tang, Wei Wang, Hai-Bing Zhou. Gossypol with hydrophobic linear esters exhibits enhanced antitumor activity as an inhibitor of antiapoptotic proteins. ACS medicinal chemistry letters. 2016, 7(12):1185-1190. 17．Zhang Qianying,  Li Zhike, Wu Shuangchan, Hong Ding. Myricetin alleviates cuprizone induced behavioral dysfunction and demyelination in mice by Nrf2 pathway. Food and function. 2016, 7(10):4332-4342.18. Yue Y, Wu Shuangchan, Hong Ding. Characterization and hepatoprotective effect of polysaccharides from Ziziphusjujuba Mill. var. spinosa (Bunge) Hu ex HF Chou sarcocarp[J]. Food and Chemical Toxicology. 2014, 74: 76-84.19. Cao, X., Wu Shuangchan, et al., A high-throughput method for the simultaneous determination of multiple mycotoxins in human and laboratory animal biological fluids and tissues by PLE and HPLC–MS/MS. Journal of Chromatography B. 2013, 942-943:113-25.专利：1.   丁虹；武双婵；岳源，3-氨基-1-丙烷磺酸及其衍生物在制备脑卒中的药物中的应用。ZL 201210287615.8;2.   丁虹;岳源;武双婵;李建;谢剑梅;王淇漫GAOH衍生物及其医药用途。ZL 20151 0003889.3;3.   丁虹；武双婵；岳源甘氨酸-L-半胱氨酸-高牛磺酸三肽及其应用。ZL201210534121.5;4.   丁虹;岳源;武双婵;杨阁 一种多糖组合物及其制备方法和用途。ZL 201210090100.9;5.   丁虹;岳源;武双婵 一种壳聚糖与三肽组合物及其制备方法和应用。ZL 201310396559.66.   童静;丁虹;武双婵;李建;岳源 半胱氨酸？高牛磺酸二肽及其衍生物及其医药用途。ZL 201510569359.5 内容来自集群智慧云企服 软件产品登记测试全国受理

学术成果

综合介绍 General Introduction 个人相册

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综合介绍