张晓健科研成果

个人简介 张晓健，博士，副教授，毕业于香港城市大学，主要从事重大疾病治疗药物、高端营养健康化学品的生物合成方面技术开发与应用。近年来主持国家重点研发计划子课题、浙江省公益应用项目、企业横向合作项目多项。在Bioresource Technology、Journal of Agricultural and Food Chemistry等相关领域知名期刊发表多篇论文，讲授《生物催化工艺学》、《现代生物技术进展》等课程，指导学生获校级课外研究课题多项。 教学与课程 主讲现代生物技术进展、生物催化工艺学 育人成果 科研项目 主持国家重点研发计划子课题、浙江省公益应用项目、企业横向合作项目等多项。 科研成果 (1)   Zhang Xiao-Jian; Deng Han-Zhong; Liu Nan; Gong Yi-Chuan; Liu Zhi-Qiang*; Zheng Yu-Guo; Molecular modification of a halohydrin dehalogenase for kinetic regulation to synthetize optical pure (S)-ECH,Bioresource Technology, 2019, 276:154-160.(2)   Zhang Xiao-Jian; Shi Ping-Xiu; Deng Han-Zhong; Wang Xin-Xin; Liu Zhi-Qiang*; Zheng Yu-Guo; Biosynthesis of chiral epichlorohydrin using an immobilized halohydrin dehalogenase in aqueous and non-aqueous phase,Bioresource Technology, 2018, 263:483-490.(3)   Zhang Xiao-Jian; Wang Wen‑Zhong; Zhou Rong; Liu Zhi-Qiang*, Zheng Yu-Guo. Asymmetric synthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate using a self-sufficient biocatalyst based on carbonyl reductase and cofactor co-immobilization, Bioprocess and Biosystems Engineering, 2019, 43: 20-31. (4)   Zhang Xiao-Jian; Zheng Ling; Wu Di; Zhou Rong; Liu Zhi-Qiang*, Zheng Yu-Guo. Production of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate using carbonyl reductase coupled with glucose dehydrogenase with high space-time yield,Biotechnology Progress, 2019, 36(1): 0-UNSP e2900.(5)   Zhang Xiao-Jian; Fan Hao Hao; Liu Nan; Wang Xin Xin; Cheng Feng; Liu Zhi-Qiang*; Zheng Yu-Guo; A novel self-sufficient biocatalyst based on transaminase and pyridoxal 5 '-phosphate covalent co-immobilization and its application in continuous biosynthesis of sitagliptin,Enzyme and Microbial Technology, 2019, 130: 0-UNSP 109362.(6)   Zhang Xiao-Jian; Li Hai-Wei; Wang Bin; Dou Bao-Juan; Liu Zhi-Qiang*; Zheng Yu-Guo. Efficient Synthesis of Sugar Alcohols under Mild Conditions Using a Novel Sugar-Selective Hydrogenation Catalyst Based on Ruthenium Valence Regulation. Journal of Agricultural and Food Chemistry ，2020，68.44:12393-12399.(7)   Zhang Xiao-Jian; Wu Di; Wang Wen‑Zhong; Cao min; Liu Qian; Liu Zhi-Qiang*; Zheng Yu-Guo. Highly efficient synthesis of rosuvastatin intermediate using a carbonyl reductase-cofactor co-immobilized biocatalyst in the non-aqueous biosystem. Journal of Chemical Technology and Biotechnology. 2021, 96(11): 3094-3100. 社会服务

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