张国富科研成果

个人简介     张国富，男，1975年11生，山东临沂人，博士，副教授。1998年毕业于山东烟台师范学院（现鲁东大学）化学教育专业，获学士学位；1998年9月至2001年6月在浙江工业大学应用化学专业攻读硕士，获工学硕士学位；2001年6月至2003年8月在中国科学院大连化学物理研究所药物研究所从事药物合成研究；2003年9月到2007年5月在中国科学院大连化学物理研究所攻读博士，获有机化学博士学位；2007年9月到2009年8月在中科院上海有机化学研究所陆天尧课题组从事博士后研究工作，2009年8月进入浙江工业大学化学工程学院从事教学科研工作，2013年-2014年在美国The Scripps Research Institute 从事访问学者/博士后研究工作。    主要从事农药医药及其中间体的绿色工艺开发和工程化研究，曾获浙江省科学技术二等奖1项、浙江省“优秀工业新产品新技术”三等奖1项。担任J. Org. Chem, Synlett, Catal. Lett., Chin. J. Chem., J. Heter. Chem.,有机化学、应用化学等杂志特约审稿人。培养的研究生中有5人获得浙江省优秀毕业生，有3人获得浙江工业大学“十佳学术之星”荣誉称号，有3人获得国家奖学金，有3名研究生毕业论文和2名本科生毕业论文分别被评为浙江工业大学优秀论文 教学与课程 本科生课程：《有机化学》、《有机化学实验》研究生课程：《药物合成单元操作》、《分子结构与反应活性》 科研项目 ● 主持国家自然科学基金面上项目（青年基金）：芳香化合物有氧直接氧化偶联反应研究● 主持国家博士后科学基金：基于蒽和五并苯为连接基团的双股高分子材料研究● 主持浙江省高等学校优秀青年教师资助计划项目：环钯化合物的固载新方法及其在偶联反应中的应用● 主持浙江省教育厅科研计划项目：无氯wacker氧化新体系的研究● 主持浙江工业大学高层次引进人才科研启动专项基金：芳香化合物和酮的氧化硫氰化研究● 主持浙江省重点创新团队“化工行业安全生产关键技术及装置”子项目：酸性二氯乙烷的自动化安全生产技术及其产业化开发（2011R09019-15）● 主持浙江省科技厅重大科技创新团队“染料农药创制及共性技术研发科技创新团队”子项目：一类新三唑化合物的合成及活性筛选（2010R50018-7），● 主持浙江省自然科学基金：新型环糊精水相催化剂：设计、合成及其催化性能研究（LY13B020017）● 主持江苏省科技厅基金：甲氧虫酰肼环境友好型农药产业化开发研究（江苏省双创计划科技副总）●主持重大横向项目：新型除草剂精都尔及其催化剂二氯-双[1,5-环辛二烯]铱的合成工艺研与产业化开发，杭州庆丰农化有限公司（100万）●主持重大横向项目：2-氨基-4-乙酰氨基苯甲醚的清洁工艺及产业化开发，江苏之江化工有限公司（305万）●主持横向项目：6-溴-2,4-二硝基苯胺的清洁工艺研究及产业化开发，杭州科峰化工有限公司（360万） 科研成果 2021年度1.      Guofu Zhang, Qiankun Fan, Huimin Wang, Yiyong Zhao, Chengrong Dinga,*, NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions. Advanced Synthesis & Catalysis, 2021, 363, 833 – 837 (DOI: 10.1002/adsc.202001202).2.      Guofu Zhang, Qiankun Fan, Yiyong Zhao, HuiminWang, Chengrong Ding*, Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides. Synlett2021, 32（01）：81-85, (DOI: 10.1055/s-0040-1707310)3.      Guofu Zhang, Jing Wang,  Chenfei Guan, Yiyong Zhao, and Chengrong Ding,，Nickel and Palladium-Catalyzed Cross-Coupling of Aryl Fluorosulfonates and Phosphites: Preparation of Arylphosphonates，Eur. J. Org. Chem. 2021, 810 –813，（DOI: 10.1002/ejoc.202001485). 2020年度4.      Yiyong Zhao, Junjie Wei, Shuting Shuting Ge, Zhang Guofu*,Chengrong Ding*,，SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN), RSC Advance, 2020, 10( 29): 17288-17292 (DOI: 10.1039/d0ra02631j).5.      Guofu Zhang, Lidi Xuan, Yiyong Zhao, Chengrong Ding,，Sulfuryl Fluoride Promoted Thiocyanation of Alcohols: A Practical Method for Preparing Thiocyanates，Synlett 2020; 31(14): 1413-1417. (DOI: 10.1055/s-0040-1707151).6.      Guofu Zhang, Yin Cui, Yiyong Zhao, Yunqiang Cui, Shenxiao Bao, Chengrong Ding，A Practical Approach to Ureas and Thiocarbamates: SO2F2-Promoted Lossen Rearrangement of Hydroxamic Acid，ChemistrySelect 2020; 5(26): 7817-7821. (DOI: 10.1002/slct.202002270). 2019年度7.      Guofu Zhang, Yiyong Zhao, Chengrong Ding*. A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangemen, Organic & Biomolecular Chemistry,2019, 17(33), 7684-7688（DOI: 10.1039/c9ob01547g）.8.      Guofu Zhang, Qiankun Fan, Yiyong Zhao, Chengrong Ding*.Copper-Promoted Oxidative Intramolecular C-H Amination of Hydrazones to Synthesize 1H-Indazoles and 1H-Pyrazoles Using a Cleavable Directing Group, European Journal of Organicn Chemistry, 2019,(33),5801-5806.（DOI: 10.1002/ejoc.201900947）. 9.      Guofu Zhang, Yiyong Zhao,Lidi Xuan, Chengrong Ding*.  SO2F2-Activated Efficient Beckmann Rearrangement of Ketoximes for Accessing Amides and Lactams, European Journal of Organicn Chemistry, 2019,(30),4911-4915.（DOI: 10.1002/ejoc.201900844. ）10.  Yiyong Zhao, Guangyao Mei, Haibo Wang, Guofu Zhang*, Chengrong Ding*, SO2F2-Promoted Dehyhration of Aldoximes: A Rapid and Simple Access to Nitriles, Synlett 2019; 30(12): 1484-1488.（DOI: 10.1055/s-0037-1611840) .11.  Guofu Zhang, Jianfei Zhu, Lidi Xuan, Chengrong Ding*. Silver-Mediated Methoxylation of Aryl C(sp(2))-H Bonds Directing by DMEDA, Catalysts, 2019,9(2), 171  （DOI: 10.3390/catal9020171）.12.  Chengrong Ding, Yayun Pan, Xu Yin, Chengxia Tan*, Guofu Zhang*. Synthesis and Insecticidal Activity of Novel Piperidine Thiazole Compounds, Chinese Journal of Organic Chemsitry,2019,39(3), 836-841，（DOI: 10.6023/cjoc201809009）. 2018年度13.  Guofu Zhang, Jianfei Zhu, Chengrong Ding*. Pharmaceutical-Oriented Iron-Catalyzed Ethoxylation of Aryl C(sp(2))-H Bonds with Cobalt Co-Catalyst, Chemistryselect, 2018 3(34), 9803-9806，DOI: 10.1002/slct.201801881.14.  Guofu Zhang, Yunzhe Xing, Shengyun Xu, Chengrong Ding*, Shang Shan*. Fe(III)/l-Valine-Catalyzed One-Pot Synthesis of N-Sulfinyl- and N-Sulfonylimines via Oxidative Cascade Reaction of Alcohols with Sulfinamides or Sulfonamides, Synlett 2018; 29(09): 1232-1238 ().DOI: 10.1055/s-0037-1609320.15.  Guofu Zhang, Jianfei Zhu, Chaolai Tong, Chengrong Ding*. Pharmaceutical-Oriented Methoxylation of Aryl C(sp2)–H Bonds using Copper Catalysts, Synlett, 2018, 29(11): 1451-1454. DOI: 10.1055/s-0037-161013216.  Yongshu Li, Nizhou Xu, Guangyao Mei, Yun Zhao, Yiyong Zhao, Jinghui Luh, Guofu Zhang, Chengrong Ding*. Fe(NO3)3. 9H2O-catalyzed aerobic oxidative deoximation of ketoximes and aldoximes under mild conditions. Candian Journal of Chemistry, 2018, 96(8): 810-814. DOI: 10.1139/cjc-2017-0567,17.  Guofu Zhang, Danting Ma, Yiyong Zhao, Guihua Zhang, Guangyao Mei, Jinghui Luv, Chengrong Ding*, Shang Shan. NH3.H2O: The simplest nitrogen-containing ligand for selective aerobic alcohol oxidation to aldehydes or nitriles in neat water. Chemistryopen, 2018, 7(11): 885-889. DOI:10.1002/open.201800196 2017年度18.  Guofu Zhang, Yue Li, Xiaoqiang Xie, Chengrong Ding*. Ru-catalyzed regioselective direct hydroxymethylation of (hetero)arenes via C-H activation, Org. Lett., 2017, 19(5), 1216−1219, DOI: 10.1021/acs.orglett.7b0018319.  Guofu Zhang, Shengjun Xu, Xiaoqiang Xie, Chengrong Ding* and Shang Shan*. Direct synthesis of N-sulfinyl- and N-sulfonylimines via copper/L-proline-catalyzed aerobic oxidative cascade reaction of alcohols with sulfinamides or sulfonamides, RSC Adv., 2017, 7, 9431–9435 (DOI:10.1039/C6RA26490E). 20.  Guofu Zhang, Yidong Yu, Yiyong Zhao, Xiaoqiang Xie, Chengrong Ding*. Iron(III)/TEMPO-Catalyzed Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles by Oxidative Cyclization under Mild Conditions, Synlett, 2017; 28(11): 1373-1377 (DOI: 10.1055/s-0036-1588747).21.  Xiaoqiang Xie, Yunzhe Xing, Guofu Zhang*, Chengrong Ding*.  Pd/C-Catalyzed C-H Arylation with Click-triazoles as Rosmovable Directing Group,Chinese J. Org .Chem., 2017; 37(8): 2124-2130 (DOI: 10.6023/cjoc201612054). 2016年度22.  Guofu Zhang, Guihua Zhang, Jie Lei, Shasha Li, Shengjun Xu, Chengrong Ding*, Shan Shang*. Aerobic Alcohol Ammoxidation Catalyzed by Copper(I)/Amino acid: a Scalable Protocol to Nitrile, Chem. Res. Chin. Univ., 2016, 32(4), 586-593 DOI: 10.1007/s40242-016-6067-923.  Guofu Zhang, Shasha Li, Jie Lei, Guihua Zhang, Xiaoqiang Xie, Chengrong Ding*, Renhua Liu*. An Efficient Biomimetic Aerobic Oxidation of Alcohols Catalyzed by Iron Combined with Amino Acids, Synlett, 2016, 27(6), 956-960. DOI: 10.1055/s-0035-1561290 2015年度24.  Guofu Zhang, Xiaoqiang Xie, Jianfei Zhu, Shasha Li, Chengrong Ding* and Ping Ding. Pd(II)-catalyzed C(sp3)-H arylation of amino acid derivatives with click-triazoles as removable directing group, Org. Biomol. Chem., 2015, 13(19), 5444-5449. DOI: 10.1039/c5ob00066a25.  Guofu Zhang, Wei Zhang, Chengrong Ding*. PEG Click-Triazole Palladacycle: An Efficient Precatalyst for Palladium-Catalyzed Suzuki-Miyaura and Copper-free Sonogashira Reactions in Neat Water, Chin. J. Chem., 2015, 33(7):705-710. Accepted. DOI: 10.1002/cjoc.20150016726.  Guofu Zhang, Jie Lei, Xingwang Han, Yuxin Luan, Chengrong Ding* and Shang Shan*. N-Functionalized Amino Acids Promoted Aerobic Copper-Catalyzed Oxidation of Benzylic Alcohols in Water, Synlett, 2015, 26(6), 779-784. DOI: 10.1055/s-0034-1380126; 2014年度27.  Wei Gong, Guofu Zhang（共同第一作者）, Tao Liu, Ramesh Giri and Jin-Quan Yu*. Site-Selective C(sp3)-H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus. J. Am. Chem. Soc., 2014, 136(48), 16940-16946. 28.  Guofu Zhang, Yuxin Luan, Xingwang Han, Yong Wang, Xin Wen and Chengrong Ding*. Pd(l-proline)2 complex: an efficient catalyst for Suzuki–Miyaura coupling reaction in neat water, Appl. Organomet. Chem., 2014, 28(5), 332-336.DOI: 10.1002/aoc.3129 2013年度29.  Guofu Zhang, Xin Wen, Yong Wang, Xingwang Han, Yuxin Luan, Lebin Zheng, Chengrong Ding* and Xiaoji Cao*. In situ generation of active species “NO” for the aerobic oxidative deprotection of aldoximes catalyzed by FeCl3/TEMPO, RSC Adv., 2013, 3(45), 22918-22921. (DOI: 10.1039/c3ra45205k)30.  Guofu Zhang, Xingwang Han, Yuxin Luan, Yong Wang, Xin Wen, Li Xu*, Chengrong Ding and Jianrong Gao. Copper-catalyzed aerobic alcohol oxidation under air in neat water by using a water-soluble ligand, RSC Adv., 2013, 3(42), 19255-19258. DOI: 10.1039/c3ra43366h31.  Guofu Zhang, Xingwang Han,Yuxin Luan, Yong Wang, Xin Wen, Chengrong Ding*. L-Proline: an efficient N,O-bidentate ligand for copper-catalyzed aerobic oxidation of primary and secondary benzylic alcohols at room temperature, Chem. Commun., 2013, 49(72), 7908-7910. DOI: 10.1039/c3cc44122a32.  Guofu Zhang, Yuxin Luan, Xingwang Han, Yong Wang, Xin Wen, Chengrong Ding*. A palladium complex with functionalized beta-cyclodextrin: a promising catalyst featuring recognition abilities for Suzuki-Miyaura coupling reactions in water, Green Chem., 2013, 15 (8), 2081-2085. (DOI: 10.1039/c3gc40645h)33.  Guofu Zhang, Xiaoqiang Xie, Yong Wang, Xin Wen, Yun Zhao, Chengrong Ding*. Highly selective Wacker reaction of styrene derivatives: a green and efficient aerobic oxidative process promoted by benzoquinone/NaNO2/HClO4 under mild conditions, Org. & Biomol. Chem., 2013, 11(18),2947-2950. DOI: 10.1039/c3ob40277k34.  Jianquan Weng*, Zhiqin Yu, Xinghai Liu, Guofu Zhang*. Palladium-catalyzed direct oxidative ortho-acylation of anilides with toluene derivatives. Tetrahedron Letters, 2013, 54(10): 1205-1207. 2012年度35.  Guofu Zhang, Yong Wang, Xin Wen, Chengrong Ding*, Ying Li. Dual-functional click-triazole: a metal chelator and immobilization linker for the construction of heterogeneous palladium catalyst and its application for the aerobic oxidation of alcohols, Chem. Commun., 2012, 48(24), 2979-2981. DOI:10.1039/C2CC18023E.36.  Guofu Zhang, Xiaobao Zhao, Yunbing Yan, Chengrong Ding*, Direct arylation under catalysis of an oxime-derived palladacycle: search for a phosphane-free method, Eur. J. Org. Chem., 2012,(4): 669-672. DOI: 10.1002/ejoc.201101400，37.  Chengxia Tan, Lixian Pan, Guofu Zhang, Yongshu Li*. A fFacile oxidation of thiols to disulfides catalyzed by CoSalen. Phosphorus, Sulfur, and Silicon and the Related Elements. 2012, 187(1):16-21.38.  Zhang Guofu，Wen Xin，Wang Yong，Mo, Weimin**，Ding, Chengrong**. Recent Advances in Oxidative Deoximation. Progress in Chemistry.2012, 24(2/3) : 361-369.39.  Weng Jianquan, Yu Zhiqin, Zhang Guofu*. Advances in Direct Oxidative Coupling between Unfunctionalized Arene and Olefin. Progress in Chemistry.2012, 24(4): 523-544.） 2011年度40.  Guofu Zhang, Xin Wen, Yong Wang, Weimin Mo*, Chengrong Ding*. Sodium nitrite-catalyzed aerobic oxidative deoximation under mild conditions, J. Org. Chem.2011, 76(11), 4665-4668.41.   Li Xu, Yong Wang, Xin Wen,Chengrong Ding, Guofu Zhang, * Xinmiao Liang. Aerobic oxybromination of phenols catalyzed by sodium nitrite under mild conditions, Synlett, 2011, (15): 2265-2269.42.  Zhang Guofu, Wang Yong, Ding Chengrong*,  Liu Renhua, Liang Xinmiao. Recent advances in oxybromination of aromatic compounds. Chin. J. Org. Chem. 2011, 31(6),804-813.43.  Guofu Zhang, Xiaobao Zhao, Chengrong Ding *, Huijun Liu, Liang Xinmiao. New Advances in Direct Catalytic Oxidative Coupling of Arenes, Chin. J. Org. Chem. 2011, 31 (11), 1736-1751. 内容来自集群智慧云企服