凌飞科研成果

个人简介 凌飞 副研究员/博士生导师      2016年6月获浙江大学有机化学专业博士学位，后在浙江工业大学从事博士后研究。2018年11月加入浙江工业大学药学院，任校聘副教授、硕士生导师。现任副研究员、博士生导师、药物合成工艺研究所师生联合第一党支部书记、药学院钟为慧教授纵向团队德育导师，浙江省药学院会药物化学与抗生素专委会青年委员。主要从事药物及中间体的绿色合成工艺、手性配体与催化剂的开发、选择性碳氢键活化、有机电合成方法学研究，共发表SCI论文50多篇，以第一作者/通讯作者发表37篇，包括J. Am. Chem. Soc.（1）、Green Chem.（5）、Org. Lett.（3）、Org. Chem. Front.（4）Chem. Coummun.（3）、Adv. Syn. Catal.（7）、J. Org. Chem.（7）等，封面论文和高被引论文各1篇。研究受到同行广泛关注，论文已被引804次，单篇最高被引71次。主持国家基金青年项目1项、国家自然科学基金面上项目2项、浙江省自然科学基金1项、省属高校科研业务费项目1项，博士后基金2项，主持或参与国家基金、省重点研发计划和企业横向20余项，以主要参与人参加抗击新冠病毒（2019-nCoV）肺炎应急科研专项—“瑞德西韦（Remdesivir）的创新工艺及产业化研究”，并成功实现公斤级量产。获授权中国专利25项。入选浙江工业大学首届“星耀运河”学术新星（2023），浙江工业大学青年英才A类支持对象（2023），浙江工业大学高层次人才培育计划（2022），“南太湖精英计划”领军团队核心成员（2022），浙江工业大学台州研究院创新团队核心成员（2021）。 教学与课程 主讲本科生《生产实习A》、《制药工艺课程设计》，辅讲本科生《文献检索与专利》、硕士生《高等有机化学》、博士生《不对称催化研究进展》等课程。 科研项目 纵向课题情况序号项目名称起止时间项目级别/类型经费来源及额度担任角色是否结题1基于丰产金属“再生”策略的磷手性中心不对称构建及应用 （22378363）2024.01-2027.12国家级国家自然科学基金面上项目、50万主持否2丰产金属CoMn不对称催化氢化研究（RF-B2023008）2024.01-2026.12厅局级浙江省高校基本科研业务费项目-B类项目、30万主持否3“二茂铁骨架+氮杂环卡宾”构筑手性口袋策略调控锰催化不对称氢化反应（22078298）2021.01-2024.12国家级国家自然科学基金面上、65万主持否4“边臂”强化的手性二茂铁配体在钯催化合成手性γ-丁内酯（酰胺）中的应用研究（21706234）2018.01-2020.12国家级国家自然科学基金青年项目、25万主持是5电化学促进C-H键“精准”官能团化及腺嘌呤先导化合物库的构建2021.01-2023.12省部级浙江省自然科学基金、10万主持否6手性锰催化剂的设计、合成及其在不对称催化氢化中的应用研究2019.07-2022.12厅局级浙江省高校基本科研业务费项目-A类项目、10万主持否7亚磺酰亚胺不对称电合成及其应用研究2022.03-2023.09省部级博士后科学基金委、8万主持否8基于氨基酸骨架的新型手性GAP试剂的设计、合成及应用2016.06-2019.09省部级博士后科学基金委、5万主持是9手性二茂铁PNN三齿配体的设计、合成及其在锰催化不对称催化氢化中的应用研究2019.05-2020.04院级药学院青年英才项目、5万主持是10无痕导向基促进的钴催化绿色插羰反应构建杂环化合物2017.05-2018.04院级药学院青年英才项目、5万主持是11基于二茂铁番骨架的新型手性FLP催化剂的设计、合成与应用（21676253）2017.01-2020.12国家级国家自然科学基金、72万参与是12瑞德西韦（Remdesivir）的创新工艺及产业化研究2020.02-2020.07校级抗击新冠病毒（2019-nCoV）肺炎应急科研专项、100万参与是横向课题情况序号项目名称起止时间委托单位金额（万元）担任角色是否结题1医药中间体107F的合成工艺研究2023.03.20-2026.12.31江苏恒盛药业有限公司40主持否2瑞卢戈利（Relugolix）创新合成工艺研究2021.11.16-2022.11.15诚达药业股份有限公司30主持否3反式-1-（3-甲氧基-2-哌啶基）-2-丙酮氢溴酸盐(Ridane HBr)合成工艺研究2020.08.25-2020.12.31诚达药业股份有限公司30主持是4瑞格列净中间体的合成工艺开发2019.11.06-2022.11.05杭州杜易科技有限公司30主持否5列净类原料药及医药中间体的合成工艺开发2018.01.01-2022.12.31江西华士药业有限公司60主要参与人（2/7）否63,4-二甲基吡唑磷酸盐(DMPP)和硫磷衍生物的绿色合成技术开发2018.07.01-2023.06.30浙江今晖新材料股份有限公司150主要参与人（2/5）否7三唑类杀菌剂的合成工艺开发2020.06.01-2022.06.01江西华士药业有限公司60主要参与人（2/5）否  科研成果 Qian Tang, Dingguo Song, Kali Zhang, Wenhao Mao, Xianghua Zhao, Ding Du,* Fei Ling*, Weihui Zhong*, Development of an imidazole-based N,N-bidentate ligand for the manganese catalyzed direct coupling of nitriles with alcohols. RSC Adv., 2024, 14, 12987-1292.Wenhao Mao,  Dingguo Song, Jiyuan Guo, Kali Zhang, Changdi Zheng, Jie Lin, Lian Huang, Lizhou Zheng, Weihui Zhong,* Fei Ling,* Manganese-Catalyzed Asymmetric Transfer Hydrogenation of Quinolines in Water using Ammonia Borane as a Hydrogen Source. Green Chem., 2024, DOI: 10.1039/D4GC00506F.Dingguo Song, Rong Chen, Weiwei Huang, Pengtao Yang, Lingxin Chen, Jialin Zhang, Fei Ling*, Weihui Zhong,* Room-Temperature Synthesis of α-Alkylated Indolin-2-ones via a Photo Assisted Iron Catalyzed Borrowing Hydrogen Reaction. Adv. Synth. Catal., 2024, DOI: 10.1002/adsc.202301219.Pengtao Yang, Dingguo Song, Lingxin Chen, Xianghua Zhao, YiRui Chen, Feiyang Shen, Fei Ling,* Weihui Zhong*, Dynamic Kinetic Resolution of α-F-β-Ketone Amides (Esters) via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation. Org. Chem. Front., 2024, 11, 2201-2207.Dingguo Song, Changjun Zhang, Yuqi Cheng, Linlin Chen, Jie Lin, Changdi Zheng, Ting Liu, Yuxin Ding, Fei Ling*, Weihui Zhong,* Development of a more efficient catalyst for the redox-neutral organocatalytic mitsunobu reaction by DFT-guided catalyst design. Green Synth. Catal., 2023, DOI: 10.1016/j.gresc.2023.11.002.Tao Liu, Jie Lin, Fangjun Xia, Zhenhui Xu, Wei Qian, Weihui Zhong, Dingguo Song,* Fei Ling,* Electrochemical enabled desaturated β-C(sp3)-H sulfonylation and phosphonylation of cyclic amines, Green Synth. Catal., 2023, DOI: 10.1016/j.gresc.2023.11.008.Dingguo Song, Shiliang Wang, Weiwei Huang, Rong Chen, Fangyuan Hu, LingxinCheng, Xianghua Zhao, Fei Ling*,  Weihui Zhong*, Blue-Light Induced Iron-Catalyzed Chemoselective α-Alkylation and α-Olefination of Arylacetonitriles with Alcohols. Org. Chem. Front., 2023, 10, 5908-5915.Jiayin He, Wenhao Mao. Jie Lin, Yongzhen Wu, Lingxin Chen, Pengtao Yang, Dingguo Song, Peixi Zhu, Weihui Zhong, Fei Ling,* Enantioselective Synthesis of Chiral β-Hydroxy Sulfones via Manganese Catalyzed Asymmetric Hydrogenation. Org. Chem. Front., 2023,10, 3321-3327.Lei Liu, Zhenhui Xu, Jie Lin, Zhensheng Zhang, Yongzhen Wu, Pengtao Yang, Yunfei Hang, Dingguo Song, Weihui Zhong,* Fei Ling,* NHPI/O2-Mediated Electrochemical Intermolecular Cyclization/Dehydrogenation for the Construction of Polycyclic Quinazolinones,  Adv. Synth. Catal., 2023, 365, 2248-2254.Zhenhui Xu, Wangqin Zhang, Chao Xu, Tao Liu, Zhensheng Zhang, Changdi Zheng, Dingguo Song, Weihui Zhong, Fei Ling,* Ligand promoted cobalt catalyzed electrochemical C–H annulation of arylphosphinamide and alkyne. Adv. Synth. Catal., 2023, 365, 1877-1882.Tao Liu, Wangqin Zhang, Chao Xu, Zhenhui Xu, Dingguo Song, Wei Qian, Gang Lu, Chang-Jun Zhang, Weihui Zhong, Fei Ling,* Synthesis of P-stereogenic cyclicphosphinic amide via electrochemical enabled cobalt-catalyzed enantioselective C–H annulation. Green. Chem., 2023, 25, 3606-3614.Yan Mao, Wenxi Chen, Changchang Li, Lin Miao, Yanfei Lin, Fei Ling,* Zhangpei Chen,* Jinzhong Yao,* Synthesis of 3,4,5-trisubstituted phenols via Rh(III)-catalyzed alkenyl C-H activation assisted by phosphonium cations. Chem. Commun., 2023, 59, 3775-3778.Shiliang Wang, Dingguo Song, Feiyang Shen, Rong Chen, Yuqi Cheng, Chuhan Zhao, Qilei Shen, Shuxin Yin, Fei Ling*, Weihui Zhong,* Manganese Catalyzed Cross-Coupling of Allylic Alcohols and Nitriles: An Elegant Route for Access of δ-Hydroxynitriles. Green. Chem., 2023, 25, 357-364.Wenxi Chen, Yan Mao, Min Wang, Fei Ling,* Changchang Li, Zhangpei Chen,* Jinzhong Yao,* Rh(III)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C–H activation. Org. Biomol. Chem., 2023, 21, 775-782.Xianghua Zhao, Zehui Yang, Yuqi Cheng, An Huang, Fangyuan Hu, Fei Ling,* Weihui Zhong,* Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation. Adv. Synth. Catal., 2022, 364, 3074-3080.Lei Liu, Zhenhui Xu, Tao Liu, Chao Xu, Wangqin Zhang, Xiangqi Hua, Fei Ling,* Weihui Zhong,* Electrosynthesis of 2-Substituted Benzoxazoles via Intramolecular Shono-Type Oxidative Coupling of Glycine Derivatives. J. Org. Chem.,2022, 87, 11379-11386.(Highlighted by Organic Chemistry Portal)Chao Xu, Zhensheng Zhang, Tao Liu, Wangqin Zhang, Weihui Zhong, Fei Ling,* Hydrogen evolution-enabled rhodaelectro-catalyzed [4+2] annulations of purines and 7-deazapurines with alkynes. Chem. Commun., 2022, 58, 9508-9511.Yirui Chen, Xiao Yi, Yuqi Cheng, An Huang, Zehui Yang, Xianghua Zhao, Fei Ling,* Weihui Zhong,* Rh-Catalyzed Highly Enantioselective Hydrogenation of Functionalized Olefins with Chiral Ferrocenylphosphine-Spiro Phosphonamidite Ligands. J. Org. Chem.2022, 87, 7864-7874. (Highlighted by Organic Chemistry Portal)Lei Liu, Wangqin Zhang, Chao Xu, Jiaying He, Zhenhui Xu, Zehui Yang, Fei Ling,* Weihui Zhong,* Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene. Adv. Synth. Catal., 2022, 364, 1319-1325.Fei Ling,* Tao Liu, Chao Xu, Jiaying He, Wangqin Zhang, Changwu Ling, Lei Liu and Weihui Zhong,* Divergent Electrolysis for the Controllable Coupling of Thiols with 1,2-Dichloroethane: a Mild Approach to Sulfide and Sulfoxide. Green Chem., 2022, 24, 1342-1349. (2022年高被引论文)Xiao Yi,‡ Yirui Chen,‡ An Huang, Dingguo Song, Jiaying He, Fei Ling,* Weihui Zhong,* Design of Chiral Ferrocenylphosphine-spiro Phosphonamidite Ligands for Ruthenium-Catalysed Highly Enantioselective Coupling of 1,2-Diols with Amines.  Org. Chem. Front.,2021, 8, 6830–6836.Ze Wang, Xianghua Zhao, Shiliang Wang,An Huang, Yifan Wang, Jiaying He, Fei Ling,* Weihui Zhong,*Iridium/f-Diaphos Catalyzed Asymmetric Hydrogenation of 2-Imidazolyl Aryl Ketones. Org. Biomol. Chem., 2021, 19, 9746-9751.Fei Ling,* Yifan Wang, An Huang, Ze Wang, Shiliang Wang, Jiayin He, Xianghua Zhao, Weihui Zhong,* Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of Racemic β'-Keto-β-amino Esters via Dynamic Kinetic Resolution. Adv. Synth. Catal.,2021, 363, 4714-4719.Ze Wang, Xianghua Zhao, An Huang, Zehui Yang, Yuqi Cheng, Jiachen Chen, Fei Ling*, Weihui Zhong*, Manganese catalyzed enantio- and regioselective hydrogenation of a,ß-unsaturated ketones using an imidazole-based chiral PNN tridentate ligand. Tetrahedron Lett., 2021, 82, 153389.Xiao Xiao, Bingxuan Shao, Jingyi Li, Zehui Yang, Yin-Jie Lu, Fei Ling, Weihui Zhong*, Enantioselective synthesis of functionalized 1,4-dihydropyrazolo-[4',3':5,6]-pyrano[2,3-b]quinolines through ferrocenyl-phosphine-catalyzed annulation of modified MBH carbonates and pyrazolones. Chem. Commun.,2021, 57, 4690-4693.Fei Ling,* Didi Cheng, Tao Liu, Ze Wang, Chao Xu, Lei Liu, Yujin Li, Weihui Zhong*, Recyclable and Reusable n-Bu4NBF4/PEG-400/H2O System for Electrochemical C-3 Formylation of Indoles with Me3N as a Novel Carbonyl Source. Green Chem., 2021, 23, 4107-4113. (Highlighted by synfacts, 2021, 17, 1027)Dingguo Song, Linlin Chen, Tao Liu, Jiayin He, Chao Xu, Jingyi Li, Fei Ling,* Weihui Zhong*, Ruthenium Catalyzed α-Methylation of Sulfones with Methanol as a Sustainable C1 Source. Org. Chem. Front.,2021, 8, 120-126.Haiwei Shen, Didi Cheng, Yujin Li, Tao Liu, Xiao Yi, Lei Liu, Fei Ling*, Weihui Zhong*, Late-Stage Diversification by Rutheniumelectro-Catalyzed C−H mono- and di-Acyloxylation. Green Synth. Catal., 2020, 1, 178-182.Haiwei Shen, Tao Liu, Didi Cheng, Chao Xu, Jiaying He, Yunfei Hang, Fei Ling*, Weihui Zhong,* Ruthenium-Catalyzed Electrochemical Synthesis of Indolines through Dehydrogenative [3+2] Annulation with H2 Evolution. J. Org. Chem., 2020,85, 13735-13746.Wenjun Luo, BingXuan Shao, Jingyi Li, Xiao Xiao,Dingguo Song, Fei Ling, Weihui Zhong*, Construction of Spirooxindole-Fused Spiropyrazolones Containing Contiguous Three Stereogenic Centres via [3+2] Annulation Utilizing Ferrocene Derived Bifunctional Phosphine-Catalyst. Org. Chem. Front., 2020,7, 1016-1021.Fei Ling,* Dingguo Song; Linlin Chen, Tao Liu, Mengyao Yu, Yan Ma, Lian Xiao, Min Xu, Weihui Zhong*, Synthesis ofN-Alkyl 2-Arylindole from Saturated Ketones and 2-Alkynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade. J. Org. Chem., 2020, 85, 3224-3233.Fei Ling, Jiachen Chen, Sanfei Nian, Huacui Hou, Xiao Yi, Feifei Wu, Min Xu, Weihui Zhong∗, Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand. Synlett, 2020, 31, 285-289.Chongren Ai, Haiwei Shen, Dingguo Song, Yujin Li, Xiao Yi, Ze Wang, Fei Ling,* Weihui Zhong,* Metal- and Oxidant-Free Electrochemical Synthesis of Sulfinic Ester via Sequential Oxidative S−H Bond Cleavage and Double S−O Bond Formation. Green Chem.2019, 21, 5528-5531.Sanfei Nian,#Fei Ling,# Jiachen Chen, Ze Wang, Haiwei Shen, Xiao Yi, Yun-Fang Yang, Yuanbin She, Weihui Zhong,* Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis. Org. Lett., 2019, 21, 5392-5396.Fei Ling, Huacui Hou, Jiachen Chen, Sanfei Nian, Xiao Yi, Ze Wang, Dingguo Song, Weihui Zhong*,Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones using an Imidazole-Based Chiral PNN Tridentate Ligand. Org. Lett., 2019, 21(11), 3937-3941.Fei Ling, Zhen Xie, Jiachen Chen, Chongren Ai, Ze Wang, Haiwei Shen, Xiao Yi, Weihui Zhong*,Co balt(II)-Catalyzed [5+2] C-H Annulation of o-Arylanilines with Alkynes: An Expedient Route to Dibenzo-[b,d]azepines, Adv. Synth. Catal., 2019, 361(13), 3094-3101.Wenjun Luo, Bingxuan Shao, Jingyi Li, Dingguo Song, Xiao Yi, Fei Ling, Weihui Zhong*, Divergent synthesis of spirocyclopentene-pyrazolones and pyrano[2,3-c]-pyrazoles via Lewis base controlled annulation reactions. Tetrahedron Lett., 2019, 60(44), 151206.Fei Ling, Jiachen Chen, Zhen Xie, Huacui Hou, Zhentao Pan, Cong Feng, Haiwei Shen, Weihui Zhong*, Synthesis of substituted quinolines via B(C6F5)3-catalyzed aniline-aldehyde-pyruvate oxidative annulation, J. Heterocyclic Chem.,2019, 56, 3333-3342.Zhentao Pan, Hui Wang, Fei Ling, Lian Xiao, Dingguo Song, Weihui Zhong*, Development of [3]ferrocenophane-derived N/B frustrated Lewis pairs for the metal-free catalytic hydrogenation of imines. Syn. Commun., 2019, 49, 522-528;Fei Ling, Lian Xiao, Lu Fang, Cong Feng, Zhen Xie, Yaping Lv, Weihui Zhong*, Metal Free B(C6F5)3-Catalyzed Markovnikov Addition of Indoles to Unactivated Alkynes. Org. Biomol. Chem., 2018, 16, 9274-9278.Fei Ling, Sanfei Nian, Jiachen Chen, Wenjun Luo, Ze Wang, Yaping Lv, Weihui Zhong*, Development of Ferrocene-Based Diamine-Phosphine-Sulfonamide (f-Diaphos) Ligands for Iridium Catalyzed Asymmetric Hydrogenation of Ketones. J. Org. Chem., 2018, 83, 10749-10761.Fei Ling, Chaowei Zhang, Chongren Ai, Yaping Lv, Weihui Zhong*, Metal Oxidant Free Cobalt Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines:An Approach Towards Free (NH)-Phenanthridinones. J. Org. Chem., 2018, 83, 5698-5706.Zhentao Pan, Leixin Shen, Fei Ling, Weihui Zhong*, B(C6F5)3-catalyzed asymmetric reductive amination using NH3-BH3. J. Org. Chem., 2018, 83, 11502-11509.Fei Ling, Lian Xiao, Lu Fang, Yaping Lv, Weihui Zhong*, Copper Catalysis for Nicotinate Synthesis through β-Alkenylation/Cyclization of Saturated Ketones with β-Enamino Esters. Adv. Synth. Catal., 2018, 360, 444-448.Wenjun Luo, Dingguo Song, Lu Fang, Sanfei Nian, Huacui Hou, Fei Ling,Weihui Zhong*, Chiral Bifunctional Ferrocenylphosphine-Catalyzed Enantioselective Allylic Alkylation of Morita−Baylis−Hillman Carbonates with Pyrazolin-5-ones. Asian J. Org. Chem.,2018, 7, 2417-2421;Fei Ling, Leixin Shen, Zhentao Pan, Lu Fang, Dingguo Song, Zhen Xie, Weihui Zhong*, B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines. Tetrahedron Lett.,2018, 59, 3678-3682.Lu Fang, Liang Qi, Longfei Ye, Zhentao Pan, Wenjun Luo, Fei Ling, Weihui Zhong*, Dimethyl Sulfoxide-Accelerated Reductive Deamination of Aromatic Amines with T-BuONO in Tetrahydrofuran. J. Chem. Res., 2018,42, 579-583.Liang Qi, Huacui Hou, Fei Ling, Weihui Zhong,* The cinchona alkaloid squaramide catalyzed asymmetric Pictet–Spengler reaction and related theoretical studies. Org. Biomol. Chem., 2018, 16, 566-574.Fei Ling, Chongren Ai, Lv, Yaping, Weihui Zhong*, Traceless Directing Group Assisted Cobalt-Catalyzed C-H Carbonylation of Benzylamines. Adv. Synth. Catal., 2017, 359, 3707-3712.Fei Ling, Chongren Ai, Yaping Lv, Weihui Zhong*, Formation of N-Unprotected Isoindolinones from Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)-H Carbonylation. Adv. Synth. Catal., 2017, 359, 3675.Wenjun Luo, Haiwen Hu, Sanfei Nian, Liang Qi, Fei Ling, Weihui Zhong,* Phosphine-catalyzed [3+2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonenes-1,3-dione. Org. Biomol. Chem., 2017, 15, 7523-7526.王辉，郑亿，潘振涛，傅鸿樑，凌飞，钟为慧*，“受阻”路易斯酸碱对催化氢化反应的研究进展. 有机化学，2017, 37(2), 301-313.Xuchun Zheng, Yanjun Wan, Fei Ling, Cheng Ma,* Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles. Org. Lett.,2017, 19, 3859-3862.Dong Cheng, Fei Ling, Chenguang Zheng, Cheng Ma,* Tuning of Copper-Catalyzed Multicomponent Reactions toward 3-Functionalized Oxindoles. Org. Lett.,2016, 18, 2435-2438.Fei Ling, Yanjun Wan, Dongxu Wang, Cheng Ma,* Coupling and Decoupling Approach Enables Palladium-Catalyzed Aerobic Bimolecular Carbocyclizations of Enediynes to 2,6-Diacylnaphthalenes. J. Org. Chem., 2016, 81, 2770-2781.Dongxu Wang, Fei Ling, Xiang Liu, Zexiang Li, Cheng Ma,* Aerobic Dimerization of Enediyne Compounds: Construction of Naphthalene Frameworks. Chem. Eur. J., 2016,22, 124-128.Xiaonan Yan, Fei Ling, Yuchen Zhang, and Cheng Ma,* Three-Component Functionalized Dihydropyridine Synthesis via a Formal Inverse Electron-Demand Hetero-Diels–Alder Reaction. Org. Lett., 2015, 17, 3536-3539.Zexiang Li,#Fei Ling,# Dong Cheng, Cheng Ma,* Pd-Catalyzed Branching Cyclizations of Enediyne-Imides toward Furo[2,3-b]pyridines. Org. Lett.,2014, 16, 1822-1825.Fei Ling, Zexiang Li, Chenguang Zheng, Xiang Liu, and Cheng Ma,* Palladium/Copper-Catalyzed Aerobic Intermolecular Cyclization of Enediyne Compounds and Alkynes: Interrupting Cycloaromatization for (4 + 2) Cross-Benzannulation. J. Am. Chem. Soc.,2014, 136, 10914-10917.Dong Cheng, Fei Ling, Zexiang Li, Weijun Yao, and Cheng Ma, Three-Component Assembly of Conjugated Enyne Scaffolds via E-Selective Olefination of Ynals. Org. Lett., 2012, 14, 3146-3149.     课题组成员            刘涛 2019级博士  徐振辉 2021级硕士                 毛文浩 2021级硕士  张贞生 2021级硕士                  吴永珍 2021级硕士   林捷 2022级硕士                     夏徐滢 2022级硕士   杭云飞 2022级硕士                 郭济源 2022级硕士  张卡利 2022级硕士           王敏 2022级硕士（联合培养）  郑昌迪 2023级硕士                   唐艳 2023级硕士  邓正国 2023级硕士                    张文继 2023级硕士毕业生：徐超 2020级硕士            张旺钦 2020级硕士        何佳颖 2020级硕士                 陈文汐 2020级硕士（联合培养）毛艳 2020级硕士（联合培养）       课题组活动 2021年11月课题组第一次在德清聚餐2021年博士（王泽、伊晓）毕业合影2021年5月赴德清团建活动2021年4月纵向团队羽毛球赛 内容来自集群智慧云企服 发明专利4999元代写全部资料全国受理