魏斌科研成果

个人简介 博士，讲师，硕士生导师，主持国家重点研发计划青年科学家项目子课题、国家自然科学基金青年基金等科研项目8项，参与国家重点研发计划等其他横纵向项目6项。已在Microbiome, Biotechnol. Adv., Environ. Microbiol., Syn. Syst. Biotechno., J. Nat. Prod.等国际权威期刊发表SCI论文70余篇(ESI高被引论文2篇)，其中以第一/通讯作者发表学术论文30篇，引用1200余次。获授权发明专利11项，软件著作权4项。个人荣誉:2022年度绿色制药协同创新中心优秀教师2022年度Front. Microbial. 期刊优秀审稿编辑2023年入选浙江工业大学青年英才B类人才项目2023年入选浙江工业大学高层次人才(C类优先资助)培育计划学习经历:2007.09-2011.06  获武汉大学学士学位，导师: 刘天罡教授2011.09-2013.06  获武汉大学硕士学位，导师: 洪葵教授2013.09-2018.08  获澳门大学博士学位，导师: 燕茹教授工作经历:2018.11-至今  浙江工业大学，讲师研究方向:1. 海洋微生物天然产物高效发现2. 微生物天然产物和代谢酶发现新策略3. 天然产物与肠道菌相互作用研究学术任职:1. 中国药学会海洋药物专业委员会青年委员2. 中国药理学会海洋药物药理专业委员会青年委员3. 国产高影响力期刊iMeta青年编委4. Front. Microbial. 期刊审稿编辑5. Mar. Drugs, J. Mar. Sci. Eng.等期刊客座编辑个人主页:ResearchGate: https://www.researchgate.net/profile/Bin-Wei-7GoogleScholar: https://scholar.google.com/citations?user=Taoas7gAAAAJ&hl=en 科研项目 1. 国家重点研发计划青年科学家项目《基于原位富集培养和PSMPA策略的深海冷泉微生物药物先导化合物挖掘技术》子课题 60万元 主持2. 浙江省属高校基本科研业务费项目《海洋微生物药物先导物的智能发现》10万元 主持3. 国家自然科学基金面上基金项目《基于PSMPA技术的深海微生物抗细菌耐药性次级代谢产物多样性的研究》排名第二 56万元 参与4. 国家自然科学基金青年基金项目《基于宏基因组技术的肠道菌多糖裂解酶介导海藻多糖治疗代谢综合征的研究》24万元 主持5. 浙江省基础公益研究计划项目《肠道菌介导的黄嘌呤代谢对高脂饮食诱导的肥胖模型的影响》8万元 主持6. 浙江省博士后择优资助项目《海带多糖与肠道菌多糖代谢酶的相互作用研究》5万元 主持7. 自然资源部第二海洋研究所博士后项目《肠道菌多糖裂解酶介导海带多糖治疗肥胖的研究》7万元 主持8. 企业横向项目《微生物转化在工业废液处理中的应用》10万元 主持9. 企业横向项目《贵州笃山石斛口服液产品预研和质量研究》10万元 主持 科研成果 代表性学术论文(#第一作者, *通讯作者): 1. Man-Jing Ma#, Wen-Chao Yu#, Huai-Ying Sun, Bing-Cheng Dong, Gang-Ao Hu, Zhen-Yi Zhou, Yi Hua, Buddha Bahadur Basnet, Hong Wang*, Bin Wei*. Genus-specific secondary metabolome in Allokutzneria and Kibdelosporangium. Synthetic and Systems Biotechnology (2024), 9(3): 381-390. [Full text] Highlighted by 合成和系统生物技术[Link]2. Bin Wei#, Xian Luo#, Zhen-Yi Zhou, Gang-Ao Hu, Lei Li*, Hou-Wen Lin*, Hong Wang*. Discovering the secondary metabolic potential of Saccharothrix. Biotechnology Advances (2024), 70: 108295. [Full text] (中科院一区, IF=16.0) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]3. Qun-Jian Yin#, Ti-Ti Ying#, Zhen-Yi Zhou, Gang-Ao Hu, Cai-Ling Yang, Yi Hua, Hong Wang*, Bin Wei*. Species-specificity of the secondary biosynthetic potential in Bacillus. Frontiers in Microbiology (2023), 14: 1271418. [Full text]4. Bin Wei#, Gang-Ao Hu#, Zhen-Yi Zhou, Wen-Chao Yu, Ao-Qi Du, Cai-Ling Yang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Qi-Hao Wu, Qi Xuan*, Xue-Wei Xu*, Hong Wang*. Global analysis of the biosynthetic chemical space of marine prokaryotes. Microbiome (2023), 11: 144. [Full text] (中科院一区, IF=16.837) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]5. Bin Wei, Ao-Qi Du, Ti-Ti Ying (本科生), Gang-Ao Hu, Zhen-Yi Zhou, Wen-Chao Yu, Jing He, Yan-Lei Yu, Hong Wang*, Xue-Wei Xu*. Secondary metabolic potential of Kutzneria. Journal of Natural Products (2023), 86(4): 1120-1127. [Full text] (药学TOP, IF=4.803) Highlighted by 遇见生物合成[Link]; 相聚植化[Link]6. Ying Song#, Dong-Ze Lu#, Hong-Gang Wang, Zhen-Yi Zhou, Xian Luo, Man-Jing Ma, Song-Ze Ke, Hong Wang, Yan-Lei Yu, Bin Wei*. Metagenomic insights into the anti-obesity effect of a polysaccharide from Saccharina japonica. Foods (2023), 12(3): 665. [Full text]7. Ao-Qi Du#, Ti-Ti Ying# (本科生), Zhen-Yi Zhou, Wen-Chao Yu, Gang-Ao Hu, Xian Luo, Man-Jing Ma, Yan-Lei Yu, Hong Wang*, Bin Wei*. Non-ribosomal peptide biosynthetic potential of the nematode symbiont Photorhabdus. Environmental Microbiology Reports (2022), 14: 917-925. [Full text]8. Bin Wei#, Bo Zhang#, Ao-Qi Du, Zhen-Yi Zhou, Dong-Ze Lu, Zhong-Hui Zhu (本科生), Song-Ze Ke, Si-Jia Wang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin*, Hong Wang*. Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria. Carbohydrate Polymers (2022), 290: 119411. [Full text] (中科院一区, IF=10.723) Highlighted by 热心肠日报[Link]9. Song-Ze Ke#, Bo Zhang#, Yan-Lei Yu, Si-Jia Wang, Wei-Hua Jin, Jian Wu, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei*, Hong Wang*. Structural characterization of a sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice. Journal of Oceanology and Limnology (2022), 41: 300-313. [Full text]10. Bin Wei#, Ao-Qi Du#, Zhen-Yi Zhou, Cong Lai (本科生), Wen-Chao Yu, Jin-Biao Yu, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Xue-Wei Xu*, Hong Wang*. An atlas of bacterial secondary metabolite biosynthesis gene clusters. Environmental Microbiology (2021), 23(11): 6981-6992. [Full text] (工大TOP100, IF=5.476) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]11. Bin Wei#, Si-Jia Wang#, Ya-Kun Wang, Song-Ze Ke, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Jia-Dong Sun, Susanne M. Henning, Jian Wang*, Hong Wang*. Gut microbiota mediated-xanthine metabolism is associated with resistance to high-fat diet induced obesity. Journal of Nutritional Biochemistry (2021), 88: 108533. [Full text]12. Qi-Wu Zhong, Tao-Shun Zhou, Wei-Hui Qiu, Ya-Kun Wang, Qiao-Li Xu, Song-Ze Ke, Si-Jia Wang, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei*, Hong Wang*. Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida. Food Chemistry (2021), 341: 128148. [Full text] (中科院一区, IF=9.231) (ESI高被引论文)13. Song-Ze Ke#, Yan-Lei Yu#, Qiao-Li Xu, Bo Zhang, Si-Jia Wang, Wei-Hua Jin, Bin Wei*, Hong Wang*. Composition-activity relationships of polysaccharides from Saccharina japonica in regulating gut microbiota in short-term high-fat diet-fed mice. Journal of Agricultural and Food Chemistry (2021), 69(37): 11121-11130. [Full text] (中科院一区, IF=5.895)14. Bin Wei, Ya-Kun Wang, Shou-Kui Xiang, Yan Jiang, Rong Chen, Nan Hu*. Alterations of gut microbiome in type 2 diabetes mellitus patients undergone cholecystectomy. American Journal of Physiology-Endocrinology and Metabolism (2021), 320(1): E113-E121. [Full text]15. Bin Wei#, Qiao-Li Xu#, Bo Zhang, Tao-Shun Zhou, Song-Ze Ke, Si-Jia Wang, Bin Wu, Xuewei Xu*, Wang Hong*. Comparative study of Sargassum fusiforme polysaccharides in regulating cecal and fecal microbiota of high-fat diet-fed mice. Marine Drugs (2021), 19(7): 364. [Full text]16. Bin Wei#, Ya-Kun Wang#, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu*, Hong Wang*. Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis. Journal of Microbiology (2021), 59(10): 931-940. [Full text]17. Tao-Shun Zhou#, Lu-Lu He#, Jing He (本科生), Zhi-Kun Yang, Zhen-Yi Zhou, Ao-Qi Du, Jin-Biao Yu, Ya-Sheng Li, Si-Jia Wang, Bin Wei*, Zi-Ning Cui*, Hong Wang*. Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors. Bioorganic Chemistry (2021), 116: 105306. [Full text]18. Ya-Sheng Li#, Min He#, Tao-Shun Zhou#, Qin Wang#, Lu-Lu He, Si-Jia Wang, Bei Hu, Bin Wei*,  Hong Wang*, Zi-Ning Cui*. 2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors. European Journal of Medicinal Chemistry (2021), 216, 113322. [Full text] (中科院一区, IF=7.088)19. Xing-Nuo Li, Lu-Xia Hua, Tao-Shun Zhou, Ke-Bo Wang, Yuan-Yuan Wu, Mahmoud Emam, Xiao-Ze Bao, Jun Chen, Bin Wei*. Cinnamic acid derivatives: inhibitory activity against Escherichia coli β-glucuronidase and structure-activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35.1: 1372-1378. [Full text]20. Bin Wei, Qi-Wu Zhong, Song-Ze Ke, Tao-Shun Zhou, Qiao-Li Xu, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin*, Hong Wang*. Sargassum fusiforme polysaccharides prevent high-fat diet-induced early fasting hypoglycemia and regulate gut microbiota composition. Marine Drugs (2020), 18(9): 444. [Full text]21. Bin Wei#, Ya-Kun Wang#, Wen-Hui Qiu, Si-Jia Wang, Yue-Hong Wu, Xue-Wei Xu*, Hong Wang*. Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bonds. Applied Microbiology and Biotechnology (2020), 104(5): 1883-1890. [Full text]22. Xue Yang, Zhong-Hui Zhu (本科生), Xia Ji, Zhao-Ming Liu, Hua Zhang, Bin Wei*. Complete genome sequence of Micromonospora craniellae LHW63014T, a potential metal ion-chelating agent producer. Marine Genomics (2020), 57: 100830. [Full text]23. Jian-Hua Yin#, Wei Ren#, Bin Wei#, Hui-Min Huang, Ming-Xing Li, Xiao-Xiao Wu, An-Qi Wang et al. Characterization of chemical composition and prebiotic effect of a dietary medicinal plant Penthorum chinense Pursh. Food Chemistry (2020), 319: 126568. [Full text] (中科院一区, IF=9.231)24. Song-Ze Ke#, Bin Wei#, Tao-Shun Zhou, Wen-Hui Qiu, Si-Jia Wang, Jun Chen, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin, Hong Wang*. Structural characterization and α-glucosidase inhibitory and antioxidant activities of fucoidans extracted from Saccharina japonica. Chemistry & Biodiversity (2020), 17.7: e2000233. [Full text]25. Tao-Shun Zhou#, Bin Wei#, Min He#, Ya-Sheng Li, Ya-Kun Wang, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Zi-Ning Cui*, Hong Wang*. Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35(1): 1736-1742. [Full text]26. Qi-Wu Zhong#, Bin Wei#, Si-Jia Wang, Song-Ze Ke, Jian-Wei Chen, Hua-Wei Zhang, and Hong Wang*. The antioxidant activity of polysaccharides derived from marine organisms: an overview. Marine Drugs (2019), 17(12): 674. [Full text]27. Bin Wei, Wei Yang, Zhi-Xiang Yan, Qing-Wen Zhang, Ru Yan*. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies. Journal of Functional Foods (2018), 48: 210-219. [Full text]28. Bin Wei, Pan-Pan Wang, Zhi-Xiang Yan, Ru Yan*. Characteristics and molecular determinants of a highly selective and efficient glycyrrhizin-hydrolyzing β-glucuronidase from Staphylococcus pasteuri 3I10. Applied Microbiology and Biotechnology (2018), 102(21): 9193-9205. [Full text]29. Wei Yang#, Bin Wei#, Ru Yan*. Amoxapine demonstrates incomplete inhibition of β-glucuronidase activity from human gut microbiota. SLAS Discovery: Advancing Life Sciences R&D (2018), 23(1): 76-83. [Full text]30. Wang-Hui Jing#, Si-Jing Dong#, Xia-Lin Luo#, Jing-Jing Liu, Bin Wei, Wei Du, Lin Yang, Hua Luo, Yi-Tao Wang, Si-Cen Wang*, Hai-Tao Lu*. Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research (2021), 164: 105358. [Full text] (中科院一区, IF=10.334) (ESI高被引论文)代表性发明专利/软件著作: 1. 一种环烯醚萜苷类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用, 魏斌等, 中国发明专利, ZL202010405502.82. 基于扩增子序列预测细菌次级代谢潜力的PSMPA软件, 魏斌等, 中国软件著作, 2022SR02692473. 扩增子与宏基因组组装基因组关联分析软件16S-MAG-linker, 魏斌等, 中国软件著作, 2024SR0105676 教学与课程 1. 主讲本科生专业课程《药物代谢动力学》2. 主讲本科生专业课程《药品质量管理工程》 获奖情况 1. 2020年获浙江省互联网+创新创业大赛金奖1项，指导教师排名第四2. 2021年获浙江省海洋知识创新竞赛一等奖1项，指导教师排名第二3. 2023年指导本科生获第九届浙江工业大学“健行杯”本科生学术论坛三等奖1项，指导教师排名第一4. 2023年被Frontiers in Microbiology评为"2022 Outstanding Review Editor"5. 2023年指导研究生在第十四届全国微生物资源学术研讨会上获得“优秀墙报奖”，指导教师排名第一6. 2023年指导研究生获国家奖学金7. 2023年获第十六届海洋药物学术年会青年科学家论坛优秀报告奖

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