钟卫鸿科研成果

个人简介 1993 年南京大学生物系硕士毕业；2001 年浙江大学生物化学工程专业博士毕业；2003-2004 美国 University of South Florida 博士后/访问学者；2009.7-2009.9，2013.7-2013.9 美国Rensselaer Polytechnic Institute 访问教授；1993-present 浙江工业大学。现任浙江工业大学生物工程学院二级教授，微生物与发酵工程研究所所长，浙江省新世纪151人才工程第一层次，浙江省微生物学会副理事长、中国微生物学会理事\环境微生物专业委员会委员\微生物学教学工作委员会委员\微生物通报编委，国家和省精品课程“微生物学”负责人；研究方向：微生物代谢工程、生物净化与生物转化、开展了尼古丁、甲醛、低阈值恶臭VOCs微生物分解工程，生物活性物质微生物合成代谢工程，合成生物学等方面的长期研究工作，承担和完成国家自然科学基金重点项目、面上项目、863项目、浙江省重大科技攻关项目和自然科学基金等项目10余项，曾获浙江省科技进步二等奖等奖励。在Applied and Environmental Microbiology, Biotechnology and Bioengineering, Bioresource Technology, Journal of Hazard Materials, Applied Microbiology and Biotechnology, Brief in Bioinformation, Molecular Omics等国内外刊物发表100余篇论文。主编出版《基因工程技术》和《基因工程技术实验指导》等教材，获授权国家发明专利15项。 教学与课程 本科生课程：1、微生物学；2、生物技术专业导论；3、药学生物学基础。研究生课程：1、代谢工程与合成生物学；2、基因工程与分子生物学（双语）。 育人成果 培养了众多优秀的本科和硕士博士毕业生，毕业留学博士生和硕士生各1人。微生物学课程获浙江省优秀教学成果二等奖2项，校优秀教学成果一等奖和二等奖多项；个人获2004年浙江省教学技能比赛优秀奖；2015年浙江省高校“三育人”先进个人。 科研项目 近期科研项目情况：[1] 国家自然科学基金面上项目, 红球菌AH-ZY2等PAEs降解菌多底物降解机理及其调控研究 (32370104), 2024-2027, 50万;[2] 国家重点研发项目,特殊环境微生物底盘细胞的设计与构建-子课题 (2021YFA0909500),2021-2026,90万；[3] 国家自然科学基金重点项目,含硫有机废气生物净化的传质-反应过程强化基础研究 (21938012),2020-2024,300万;[4] 国家自然科学基金面上项目,假单胞菌 JY-Q 中尼古丁代谢同功簇功能和互作机制研究 (31970104), 2020-2024,56万;[5] 国家自然科学基金面上项目,废烟叶水提液中葡萄糖对假单胞菌 JY-Q 尼古丁降解抑制机制及解除研究 (31670115),2017-2020，65万;[6] 国家自然科学基金面上项目,大肠杆菌 K5 产肝素前体 heparosan 代谢控制研究(21076195),2011-2013,35万;[7] 浙江中烟公司,基于烟草内源菌的生化技术及其工业应用研究,2019-2021,118万;[8] 浙江中烟公司,基于再造烟叶品质调控的生化技术研究,2013-2016,135万。 科研成果 近期发表的代表性论文： [1] Haixia Wang, Xiaoyu Wang, Qi Tang , Lvjing Wang, Chengyu Mei, Yunhai Shao, Ying Xu, Prof. Zhenmei Lu, Weihong Zhong*, Regulation mechanism of nicotine catabolism in Sphingomonas melonis TY by a dual role transcriptional regulator NdpR, Applied and Environmental Microbiology, 2023, 89(5): 00324-23 [2] Shuai Tu, Feng Xiao, Chengyu Mei, Shuang Li, Pei Qiao, Ziyan Huang, Yan He, Zhixing Gong, Weihong Zhong*, De Novo Biosynthesis of Sakuranetin from Glucose by Engineered Saccharomyces cerevisiae, Applied Microbiology and Biotechnology, 2023, 107 (12) , pp.3899-3909 (ESI-16) [3] Min Cai, Keqi Gao, Haichan Huang, Xinyue He, Di Jiang, Weihua Jin and Weihong Zhong*, Kidney protective bioactivity guided investigation for isolation and mechanism of Sulfated heterpolysaccharide from Laminarina japonica, Process Biochemistry, 2023, online[4] Tengfei Liu, Lixiao Nin, Chenyu Mei, Lianbao Zheng, Haixia Wang, Tong Hu, Weihong Zhong*, Co-culture of Glutamicibacter sp. ZJUTW and Cupriavidus sp. LH1 enhanced dibutyl phthalate degradation in BSM and soil, Environment Research , 2023, 235: 116666. DOI 10.1016/j.envres.2023.116666 [5] Wenjia Fan, Xi Li, Jie Li, Lingxia Chen, Wenhao Wu,Weihong Zhong*, and Hongying Pan, Clinical evaluation of polymerase chain reaction coupled with quantum dot fluorescence analysis for diagnosis of Candida infection in vulvovaginal candidiasis practice, Infection and Drug Resistance, 2023, 16 , pp.4857-4865[6] Tong Hu, Jinhui Zhu, Yinghan Chai, Pei Qiao, Weihong Zhong*，Characterization of microbial diversity and important odor compounds in fermented Ma bamboo (Dendrocalamus latiflorus Munro)，LWT-Food Science and Technology, 2023, 188:115378 [7] Xinyue He; Sanying Wang; Bin Liu; Di Jiang; Fen Chen; Genxiang Mao; Weihua Jin, Weihong Zhong*, Sulfated modification of hyaluronan tetrasaccharide enhances its antitumor activity on human lung adenocarcinoma A549 cells in vitro and in vivo. Bioorganic & Medicinal Chemistry Letters. 2022, 75:128945[8] Zeling Zhang, Xiaotong Mei, Ziliang He, Xiya Xie, Yang Yang, Chengyu Mei, Dong Xue, Tong Hu, Ming Shu, Weihong Zhong*, Nicotine metabolism pathway in bacteria: mechanism, modification, and application, Applied Microbiology and Biotechnology, 2022, 106(3): 889-904.[9] Feng Xiao, Jiazhang Lian, Shuai Tu, Linlin Xie, Jun Li, Fuming Zhang, Robert Linhardt, Haichan Huang, Weihong Zhong*, Metabolic Engineering of Saccharomyces cerevisiae for High-Level Production of Chlorogenic Acid from Glucose, ACS Synthetic Biology, 2022, 11(2): 800-81.[10] Tong Hu, Chen Yang, Zhengyu Hou, Tengfei Liu, Xiaotong Mei, Weihong Zhong*,  Phthalate esters metabolic strain Gordonia sp. GZ-YC, a potential soil degrader for high concentration Di-(2-ethylhexyl) phthalate, Microorganisms, 2022, 10(3): 641[11] Chaochao Huang, Lihui Shan, Zeyu Chen, Ziliang He, Jun Li, Yang Yang*, Ming Shu, Fanda Pan, Yang Jiao, Fuming Zhang, Robert J Linhardt, Weihong Zhong*, Differential effect of homologous NicR2A/NicR2Bs and endogenous ectopic strong promoters on nicotine metabolism in Pseudomonas sp. JY-Q, Applied and Environmental Microbiology, 2021, 87(3): e02457-20 [12] Jun Li, Shanshan Li Linlin Xie, Zeyu Chen, Guoqing Chen, Mingjie Shen, Fanda Pan, Ming Shu, Yang Yang*, Yang Jiao, Fuming Zhang, Robert J Linhardt, Weihong Zhong*, Additional Role of Nicotinic Acid Hydroxylase for the Transformation of 3-Succinoyl-Pyridine by Pseudomonas sp. Strain JY-Q,  Applied and Environmental Microbiology, 2021, 87(6): e02740-20[13] Jun Li, Linlin Xie, Shulan Qian, Yuhang Tang, Mingjie Shen, Shanshan Li, Jie Wang, Lie Xiong, Jie Lu, and Weihong Zhong, Type VI secretion system facilitates fitness, homeostasis, and competitive advantages for environmental adaptability and efficient nicotine biodegradation, Applied and Environmental Microbiology, 2021, 2021, 87(9):e03113-20[14] Jun Li, Fengmei Yi, Guoqing Chen, Fanda Pan, Yang Yang*, Ming Shu, Zeyu Chen, Zeling Zhang, Xiaotong Mei, Weihong Zhong*, Function enhancement of a metabolic module via endogenous promoter replacement for Pseudomonas sp. JY-Q to degrade nicotine in tobacco waste treatment, Applied Biochemistry and Biotechnology, 2021, 93(9): 2793-2805[15] Jun Li, Mingjie Shen, Zeyu Chen, Fanda Pan, Yang Yang*, Ming Shu, Guoqing Chen，Yang Jiao, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Expression and functional identification of two homologous nicotine dehydrogenases, NicA2 and Nox, from Pseudomonas sp. JY-Q, Protein Expression and Purification, 2021,178:105767[16] Peiwu Cui, Yunhai Shao, Yanxin Wang, Rui Zhao, Huihui Zhan, Weihong Zhong*, Co-production of biopolymers and quinone via no-sugar fermentation--a case by Methylobacterium sp. XJLM, Annal of Micorbiology, 2021, 71(1):20[17] Min Cai, Yin chen, Wang Y, Qiufu Fang, Xinyue He, Wanli Wu, Bao Y, Mao G, Weihua Jin, Weihong Zhong*, Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPAR pathway, International Journal of Biochemistry and Cell Biology, 2021, 106067[18] Tengfei Liu, Jun Li, Lequan Qiu, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Combined genomic and transcriptomic analysis of Dibutyl phthalate metabolic pathway in Arthrobacter sp. ZJUTW, Biotechnology and Bioengineering, 2020, 117(12): 3712-3726[19] Yunhai Shao, Yanxin Wang, Rui Zhao, Jianmen Chen, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Biotechnology progress for removal of indoor gaseous formaldehyde, Applied Microbiology and Biotechnology, 2020, 104(9): 3715-3727[20] Thérèse Bidja Abena Marie, Guoqing Chen, Zeyu Chen, Xiucheng Zheng, Shanshan Li, Tongtong Li, Weihong Zhong*, Changes in the diversity of soil microbial communities and enrichment of potential petroleum hydrocarbon degraders as a result of crude oil, diesel and gasoline contamination, 3 Biotech, 2020, 10:42[21] Jun Li, Jie Wang, Shanshan Li, Fengmei Yi, JianXu, Ming Shu, Mingjie Shen, Yang Jiao, Feng Tao, Chengyun Zhu, Hui Zhang, Chengyun Zhu, Jie Wang, Hui Zhang, Shulan Qian, Weihong Zhong*, Co-occurrence of functional modules derived from nicotine degrading gene clusters confers additive effects in Pseudomonas sp. JY-Q, Applied Microbiology and Biotechnology, 2019, 103: 4499- 4510[22] Hui Zhang, Rui Zhao, Chaochao Huang, Jun Li, Yunhai Shao, Weihong Zhong*, Selectively faster nicotine biodegradation by genomic modified Pseudomonas sp. JY-Q in environment coexisting with glucose, Applied Microbiology and Biotechnology, 2019,103(1): 339-348[23] Yunhai Shao, Jun Li, Yanxin Wang, Fengmei Yi, Yanan Zhang, Peiwu Cui, Weihong Zhong*, Comparative genomics and transcriptomicsinsights into the C1 metabolic model of a formaldehyde-degrading strain Methylobacterium sp. XJLW, Mol Omics, 2019, 15: 138-149 [24] Marie Thérèse Bidja Abena, Tongtong Li, Muhammad Naeem Shahc, Weihong Zhong*, Biodegradation of total petroleum hydrocarbons (TPH) in highly contaminated soils by natural attenuation and bioaugmentation, Chemosphere, 2019, 234: 864-874[25] Yunhai Shao, Yanxin Wang, Fengmei Yi, Yanan Zhang, Wangqian Liu, Chen Yang, HuiMeng, Peiwu Cui, WeihongZhong*, Gaseous formaldehyde degrading by Methylobacterium sp. XJLW, Applied Biochemistry and Biotechnology, 2019, 189(1): 262-272[26] Weihua Jin, Shuai Li, Jiale Chen, Bing Liu, Jie Li, Xueliang Li, Fuming Zhang, Robert J. Linhardt, WeihongZhong*, Increased soluble heterologous expression of a rat brain 3-O- sulfotransferase 1--a key enzyme for heparin biosynthesis, Protein express and purification, 2018, 151: 23-29[27] Jun Li, Shulan Qian, Lie Xiong, Chengyun Zhu, Ming Shu, Jie Wang, Yang Jiao, Houlong He, Fuming Zhang, Robert J. Linhardt, WeihongZhong*, Comparative genomics reveals specific genetic architectures in nicotine metabolism of Pseudomonas sp. JY-Q isolated from tobacco waste extracts, Frontiers in Microbiology, 2017, 8:2085. [28] Haichan Huang, Xiaobo Liu, Shencong Lv, WeihongZhong*, Fuming Zhang, Robert J. Linhardt, Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide, 2016, Applied Microbiology and Biotechnology, 2016, 100(18): 7877-7885[29] Lequn Qiu, Wenwen Chen, Li Zhong, Wanxin Wu, Shijin Wu, Jianmen Chen, Fuming Zhang, Weihong Zhong*, Formaldehyde biodegradation by immobilized Methylobacterium sp XJLW cells in a three-phase fluidized bed reactor, Bioprocess and Biosystem Engineering, 2014, 37(7): 1377-1384[30] Lei Zhao, Chenjing Zhu, Yang Gao, Chang Wang, Xuanzhen Li, Ming Shu, Yuping Shi, Weihong Zhong*, Nicotine degradation enhancement by Pseudomonas stutzeri ZCJ during aging process of tobacco leaves, World Journal of Microbiology and Biotechnology, 2012, 28: 2077-2086[31] Weihong Zhong*, Chenjing Zhu, Min Shu, Kedan Sun, Lei Zhao, Chang Wang, Zijuan Ye, Jianmeng Chen, Nicotine degradation by newly isolated Pseudomonas sp. ZUTSKD in the reconstituted tobacco process from tobacco wastes, Bioresource Technology, 2010, 101, 6935-6941  社会服务 Editorial Board Member for Microorganisms (ISSN 2076-2607) (2022- ),微生物学通报(ISSN 0253-2654)编委（2021-2026）,中国微生物学会理事（2021-2026），中国微生物学会环境微生物学专委会委员（2016--2021；2021-2026），中国微生物学会微生物学教学工作委委员会委员（2016--2021；2021-2026），浙江省微生物学会副理事长（2018-2023）。 内容来自集群智慧云企服 发明专利4999元代写全部资料全国受理