肖霄科研成果

个人简介 2008.09－2012.07  江西师范大学      理学学士   化学2012.09－2017.07  华东师范大学      理学博士   有机化学   导师：姜雪峰 教授 2017.11－2019.10  新加坡国立大学  博士后       有机化学   导师：Lu Yixin 教授2019.11－至今       浙江工业大学      助理研究员[ORCID: 0000-0001-9138-8511]研究方向：团队研究经费、研究生名额充足，欢迎对有机合成、药物合成方向有浓烈兴趣的同学报考。友情链接：Chemistry Reference Resolver            Data Organic Chemistry  Prof. Luo's BDE and pKa Prediction Website                 Bordwell pKa TableOrganic Chemistry Portal        Evans pKa Table              NMRs of Solvents      Solvent Drying           NMR Titration of Alkyllithium or Grignard ReagentsThe Assignment of Absolute Configuration by NMR   科研成果 科研论文：202427. X. Xiao, B. Chen, J.-W. Li, J.-B. Zheng, X. Wang, H. Zhao, F.-E. Chen*. Nitrite-Catalyzed Economic and Sustainable Bromocyclization of Tryptamines/Tryptophols to Access Hexahydropyrrolo[2,3-b]indoles/Tetrahydrofuroindolines in Batch and Flow. Chin. Chem. Lett. 2024, 35, 109280.202326. H.-J. Zhou, Y.-P. Yao, T. Zhang, B. Chen, X. Wang, H. Zhao, J. Zeng, J.-A. Chen, X. Xiao,* F.-E. Chen.* New Conformationally Flexible and Recyclable Aryl Iodine Catalysts from Inexpensive Chiral Source for Asymmetric Oxidations. Green Chem., 2023, 25, 10447-10457. Green Chem., 2023, 25, 10447–10457.pdfThis article is part of the themed collection: 2023 Green Chemistry Hot Articles.Highlighted by 化学深耕堂 Highlighted by RSC英国皇家化学会25. M. Ke, Y. Yu, L. Sun, X. Li, Q. Cao, X. Xiao,* F. Chen.* Regio- and Stereoselective Synthesis of Chiral (Z)-Trisubstituted Allylic Acid Derivatives with α-Quaternary Carbon Center via Synergistic Palladium/Copper Catalysis. Chem. Commun. 2023, 59, 2632-2635. (引用次数：3，ZJUT TOP100论文、Nature Index期刊)d2cc06820f.pdf24. Xiao, X., 2H-1-Benzopyrans and 4H-1-Benzopyrans. Science of Synthesis Knowledge Updates, 2023, 2, 117. DOI: 10.1055/sos-SD-114-00717.23. X. Gao, T.-J. Han, B.-B. Li, X.-X. Hou, Y.-Z. Hua, S.-K. Jia, X. Xiao, M.-C. Wang, D. Wei, G.-J. Mei,* Catalytic Asymmetric Dearomatization of Phenols via Divergent Intermolecular (3 + 2) and Alkylation Reactions. Nat. Commun. 2023, 14, 5189. DOI: 10.1038/s41467-023-40891-w.      22. Y.-D. Fu, X. Gao, S.-K. Jia, Xiao, X.; M.-C. Wang, L. Huang,* G.-J. Mei,* Catalyst-free Racemic and H2O/CPA-Catalyzed Asymmetric Regio-Reversed Domino Processes of Triketone Enones with Azlactones. Green Chem. 2023, 25, 5692-5697.    202221. X. Xiao,  H.-Y. Tian, Y.-Q. Huang, Y.-J. Lu, J.-J. Fang, G.-J. Zhou, F.-E. Chen.* Atom- and Step-Economic 1,3-Thiosulfonylation of Activated Allenes with Thiosulfonates to Access Vinyl Sulfones/Sulfides. Chem. Commun. 2022, 58, 6765-6768. (引用次数：10，ZJUT TOP100论文、Nature Index期刊)Chem. Commun., 2022, 58, 6765–6768.pdf20. X. Xiao, Y.-J. Lu, H.-Y. Tian, H.-J. Zhou, J.-W. Li., Y.-P. Yao, M.-L. Ke, F.-E. Chen.* Organocatalytic Atroposelective N-Alkylation: Divergent Synthesis of Axially Chiral Sulfonamides and Biaryl Amino Phenols. Org. Chem. Front. 2022, 9, 2830-2839. (引用次数：8，中科院一区论文)d2qo00219a.pdf19. X. Xiao,† Y.-Q. Huang,† H.-Y. Tian, J. Bai, F. Cheng, X. Wang, M.-L. Ke, F.-E. Chen.* Robust, Scalable Construction of an Electrophilic Deuterated Methylthiolating Reagent: Facile Access to SCD3-Containing Scaffolds. Chem. Commun. 2022, 58, 3015-3018. (引用次数：20，ZJUT TOP100论文、Nature Index期刊，Highlighted by CBG)d1cc07184j.pdf.18. F. Cheng, T. Chen, Y.-Q. Huang, J.-W. Li, C. Zhou,* X. Xiao,* F.-E. Chen.* Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters. Org. Lett. 2022, 24, 115-120. (Highlighted by Organic Chemistry Portal, 引用次数：11，中科院一区论文、Nature Index期刊) acs.orglett.1c03688.pdf17. X. Xiao, Y.-P. Yao, B. Chen, C. X. A. Tan, F.-E. Chen,* Quantum Hydrogen Tunneling Promoting Halogen-Atom and Group Transfer Chemistry. Green Synth. Catal. 2023, 4, 187-189. (Highlight)1-s2.0-S2666554922001284-main.pdf 16. X. Xiao,* B. Chen, Y.-P. Yao, H.-J. Zhou, X. Wang, N. Wang, F.-E. Chen.* Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis. Molecules 2022, 27, 6583. (引用次数：13, Special Issue)molecules-27-06583.pdf15. N. Wang,* X. Xiao, C.-X. Liu, H. Yao, N. Huang,* and K. Zou.* Recent Advances in the Total Synthesis of Aspidosperma and Kopsia Alkaloids Using Tetracyclic Pyridocarbazoles as Versatile Building Blocks. Adv. Synth. Catal. 2022, 364, 2479–2501. (引用次数：5，中科院二区论文)Adv Synth Catal - 2022 - Wang.pdf14. M. Ke, Y. Yu, K. Zhang, S. Zuo, Z. Liu, X. Xiao, and F. Chen.* Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives. Adv. Synth. Catal. 2022, 364, 1849–1854. (引用次数：5, 中科院二区论文)Adv Synth Catal - 2022 - Ke.pdf13. M. Ke, B. Qiao, Y. Yu, X. Li, X. Xiao, S.-J. Li, Y. Lan*, F. Chen.* Palladium-Catalyzed Asymmetric [3+2] Annulation of Vinylethylene Carbonates with Alkenes Installed on Cyclic N-Sulfonyl Imines: Highly Enantio- and Diastereoselective Construction of Chiral Tetrahydrofuran Scaffolds Bearing Three Vicinal and Quaternary Stereocenters. J. Org. Chem.2022, 87, 5166–5177. (引用次数：6，中科院二区论文)ACS.JOC.1C03157.PDF202112. X. Xiao, B. Shao, J. Li, Z. Yang, Y.-J. Lu, F. Ling, W. Zhong.* Enantioselective Synthesis of Functionalized 1,4-Dihydropyrazolo[4’,3’:5,6]pyrano[2,3-b]quinolines through Ferrocenyl-Phosphine-Catalyzed Annulation of Modified MBH Carbonates and Pyrazolones. Chem. Commun. 2021, 57, 4690-4693. (ZJUT TOP100论文、Nature Index期刊，引用次数：11，Highlighted by CBG).Chem. Commun., 2021, 57, 4690–4693.pdf11. X. Xiao, B.-X. Shao, Y.-J. Lu, Q.-Q. Cao, C.-N. Xia, F.-E. Chen.* Recent Advances in Asymmetric Organomulticatalysis. Adv. Synth. Catal. 2021, 363, 352-387. (引用次数：36，中科院二区论文)Adv. Synth. Catal. 2021, 363, 352 – 387.pdf10. X.-J. Zhang, Y.-M. Cheng, X.-W. Zhao, Z.-Y. Cao,* X. Xiao,* Y. Xu.* Catalytic Asymmetric Synthesis of Monofluoroalkenes and gem-Difluoroalkenes: Advances and Perspectives. Org. Chem. Front. 2021, 8, 2315-2327. (引用次数：55，中科院一区、2021年ESI高被引论文)d0qo01630f.pdf9. Z. Lu, Q. Zhang, M. Ke, S. Hu, X. Xiao*, F. Chen*. TfOH-Catalyzed [4 + 1] Annulation of p-Quinone Methides with α-Aryl Diazoacetates: Straightforward Access to Highly Functionalized 2,3-Dihydrobenzofurans. J. Org. Chem. 2021, 86, 7625–7635. (引用次数：15，中科院二区论文)J. Org. Chem. 2021, 86, 7625–7635.pdf20208. W. Luo, B. Shao, J. Li, X. Xiao, D. Song, F. Ling, W. Zhong*. Construction of Spirooxindole-Fused Spiropyrazolones Containing Contiguous Three Stereogenic Centres via [3+2] Annulation Utilizing a Ferrocene Derived Bifunctional Phosphine Catalyst.Org. Chem. Front. 2020, 7, 1016-1021. (引用次数：32)Org. Chem. Front., 2020, 7, 1016–1021.pdf7. H. Zhang*,P. Tian, L. Ma, Y. Zhou, C. Jiang, X. Lin, X. Xiao. Remote Directed Isocyanation of Unactivated C(sp3)−H Bonds: Forging Seven-Membered Cyclic Ureas Enabled by Copper Catalysis. Org. Lett. 2020, 22, 997−1002. (引用次数：22).acs.orglett.9b04542.pdf6. J. Li, L. Meng, X. Du, Q. Liu, L. Xu, L. Zhang, F. Sun, X. Li, D. Zhang, X. Xiao, H. Liu*. Palladium-Catalyzed Intramolecular Aerobic Alkenylhydroxylation of Allenamides with Alkenyl Iodides. Org. Chem. Front. 2020, 7, 3880-3886. (引用次数：11)d0qo00838a.pdfBefore ZJUT5. X. Xiao, J. Xue, X. Jiang*. Polysulfurating Reagent Design for Unsymmetrical Polysulfide Construction. Nat. Commun. 2018, 9, 2191. (引用次数：121，Highlighted by X-mol & CBG &J&K) (自然子刊，国际公认顶级期刊)Nature-communications,2018,9,2191.pdf4. X. Xiao, M. Feng, X. Jiang*. New Design of a Disulfurating Reagent: Facile and Straightforward Pathway to Unsymmetrical Disulfanes by Copper-Catalyzed Oxidative Cross-Coupling. Angew. Chem. Int. Ed. 2016, 55, 14121-14125. (引用次数：161，Highlighted by X-mol&Chem. News.) (中科院一区、TOP期刊、国际公认顶级期刊)Angew. Chem. Int. Ed.,2016,55,14121-14125.pdf3. X. Xiao, M. Feng, X. Jiang*. Transition-Metal-Free Persulfuration to Construct Unsymmetrical Disulfides and Mechanistic Study of Sulfur Redox Process. Chem. Commun. 2015, 51, 4208-4211. (引用次数：95, Highlighted by ChemInform) (ZJUT TOP100论文、Nature Index期刊)Chem. Commun., 2015, 51, 4208-4211.pdf2. Z. Dai, X. Xiao, X. Jiang*. Nucleophilic Disulfurating Reagents for Unsymmetrical Disulfides Construction via Copper-Catalyzed Oxidative Cross Coupling. Tetrahedron, 2017, 73, 3702-3706. (引用次数：35，中科院三区论文，Special Issue)Tetrahedron, 2017, 73, 3702-3706.pdf1. Z. Qiao, H. Liu, X. Xiao, Y. Fu, J. Wei, Y. Li, X. Jiang*. Efficient Access to 1, 4-Benzothiazine: Palladium-Catalyzed Double C-S Bond Formation Using Na2S2O3 as Sulfurating Reagent.Org. Lett. 2013‚ 15‚ 2594-2597. (引用次数：181)Organic letters 2013, 15, 2594-2597.pdf  专利：10. 陈芬儿，郑钧波，肖霄，陈标. 一种吡咯吲哚啉/呋喃吲哚啉类化合物的连续流制备方法.中国发明专利, 申请号：202310982299.49. 陈芬儿，肖霄，周海杰. 一种以氯霉胺为手性源的柔性手性芳基碘催化剂及其合成方法与应用.中国发明专利, 申请号：202211728729.18. 陈芬儿，李加威，肖霄. 一种吲哚啉类化合物的合成方法.中国发明专利, 申请号：202211728747.X7. 陈芬儿，肖霄，田洪宇.一种含硫醚和砜基取代的烯烃类化合物及其合成方法和应用. 中国发明专利, 申请号：202210280366.36. 陈芬儿，陆银杰，肖霄.一种碳氮轴手性磺酰胺类化合物及其合成方法和应用. 中国发明专利，专利号： ZL 2022 1 0075727.05. 陈芬儿，肖霄，黄印秋. 一种S-氘代甲基-芳基磺酰硫酯类化合物及其合成方法与应用. 中国发明专利, 申请号：202210075728.54. 钟为慧，邵炳宣，肖霄，凌飞. 一种吡喃并吡唑丙烯酸酯类衍生物及其制备方法和应用. 中国发明专利, 申请号：202110229589.23. 钟为慧，陈佳琛，凌飞，肖霄. 一种（R,E）-4-苯基丁基-3-烯-2-醇衍生物的制备方法. 中国发明专利, 公开号：CN111875474A 2. 姜雪峰，肖霄，冯明昊，芳基-芳基、芳基-烷基、烷基-烷基不对称过硫化合物及其合成方法。中国发明专利，专利号：ZL 2014 1 0606821.X1.    姜雪峰，肖霄，芳基-烷基不对称过硫类化合物及其合成方法和应用。中国发明专利，专利号：ZL 2016 1 0645101.3（PCT/CN2016/103163） 科研项目 纵向项目：3. 基于新型可回收的柔性手性芳基碘催化剂的合成及催化性能研究，国家自然科学基金委青年基金，2023-2025，主持，在研2. 泊沙康唑关键中间体的不对称合成研究，浙江省博士后科研项目择优资助一等资助，2022-2024，主持，在研1. 双功能有机膦催化及协同催化促进的硫碳键重组构建手性亚砜，浙江省自然科学基金/探索项目Q，2021-2023，主持，在研横向项目：2. 精细化学品工艺开发，2022.10-2027.09，主持，在研1. 山东泓达捐赠科研项目（到款1000万元），参与，在研 育人成果 1.在读研究生2023级：蒋海波、金雨霞、孙嘉晨、王敏2022级：陈标、郑钧波、赵航2021级：柏竣、王旭、姚伊萍、周高杰2020级：田洪宇（转博）、周海杰（转博）2.已毕业研究生2020级：李加威、黄印秋（复旦大学攻读博士学位）、俞钰燕、2019级：陆银杰、程飞（武汉工程大学联培）2018级：邵炳宣 实验条件 团队实验条件优越，实验室分析检测设备资产近千万元，包含400兆核磁、高分辨质谱、LC-MS、GC-MS、GC、红外和旋光、HPLC等；同时实验室90%为进口仪器。 课题组新闻 2023.10.23  祝贺陈标的研究论文被 Chin. Chem. Lett. 接收！2023.10.16  祝贺周海杰的研究论文被 Green Chem.接收！2022.10.18  祝贺田洪宇（国奖、一等）、黄印秋（一等）等同学获得奖学金！2022.04.11  祝贺田洪宇的研究论文被 Chem. Commun. 接收！2022.03.15  祝贺陆银杰的研究论文被Org. Chem. Front. 接收！2022.01.21  祝贺黄印秋的研究论文被 Chem. Commun. 接收！ 教学与课程 博士生课程《不对称催化研究进展》辅讲 社会服务 内容来自集群智慧云企服 软件著作权666元代写全部资料全国受理