钱海丰科研成果

个人简介        钱海丰，博士，教授，博士生导师，中科院百人计划入选者，教育部创新团队成员，美国康奈尔大学博士后，日本京都大学 JSPS 研究员；       Soil Ecology Letters 编委；生态毒理学报编委；       主持国家自然科学基金项目（8项），浙江省杰出青年基金等项目。 主要从事环境毒理学与环境生态学研究。应用目前主流的分子生物学手段并结合组学概念，从基因、蛋白、个体及群落结构等多层次、系统性分析：1）农药等污染物对植物的毒理，及其与土壤微生物之间的响应机制，了解胁迫环境下根际微生物群反馈调控植物生长发育的作用网络，阐述污染物-植物-环境微生物的三极关系；2）研究蓝藻水华诱发的水生态风险、水华蓝藻与水体微生物间的相互作用及信号传导途径，以及农药、抗生素等污染物对水生微生物群落结构和功能的安全评估；3）结合环境微生物学、生态毒理学和相关的新兴交叉领域，通过宏基因组大数据分析和人工智能技术，研究环境和人类肠道健康，重点开发基于宏基因组技术的抗生素耐药性风险评估框架以及大数据驱动的微生物资源分析，为后续研究提供重要的方法学基础。         研究成果在 Nature Communications, ISME J, Advanced Science, Microbiome, Environ Sci Technol, Water Res, Environ Microbio, Appl Environ Microbio, Environ Int, Environ Pollut, J Agric Food Chem等发表 SCI 论文 180 余篇， 其中第一或通讯作者 130 余篇， h-index=50，ESI高引/热点论文13 篇，引用7400余次。 获授权国家发明专利 6 项。 获浙江省自然科学三等奖 1 项、“十一五”浙江省自然科学基金优秀论文奖 1 项、 浙江省高校优秀科研成果奖一、二等奖各 1 项。         关于细菌耐药性的机制研究和风险评估的研究成果受到广泛关注，多家媒体对此进行报道。                担任 Nature Geoscience, Nature Communications, Environ Sci Technol, Water Research, Environ Microbio, Appl Environ Microbio 等期刊审稿人。        连续多年入选全球前2%顶尖科学家榜单。              钱海丰课题组网页链接：https://www.x-mol.com/groups/Qian_Haifeng                钱海丰课题组公众号：共生微生物（账号：ZJUTENVTOX_-1）                        科研成果 近年来发表的主要论文：2024Jin M.K., Zhang Q., Xu N.H., Zhang Z.Y., Guo H.Q., Li J., Ding K., Sun X., Yang X.R., Zhu D., Su X.X., Qian H.F.,* Zhu Y.-G.,* Lipid Metabolites as Potential Regulators of the Antibiotic Resistome in Tetramorium caespitum. Environ. Sci. Technol., 2024, 58, 4476-4486. https://doi.org/10.1021/acs.est.3c05741 Zhu, Y., Ke, M., Yu, Z., Lei, C., Liu, M., Yang, Y., Lu, T., Zhou, N., Peijnenburgc, W., Tang, T.,* Qian, H.,* Combined effects of azoxystrobin and oxytetracycline on rhizosphere microbiota of Arabidopsis thaliana. Environ. Int., 2024, 186, 108655. https://doi.org/10.1016/j.envint.2024.108655Zhang, Q., Lei, C., Jin, M., Qin, G., Yu, Y., Qiu, D., Wang, Y., Zhang, Z., Zhang, Z., Lu, T., Peijnenburg, W., Gillings, M., Yao, Z., Qian, H.,* Glyphosate disorders soil Enchytraeid gut microbiota and increases its antibiotic resistance risk. J. Agric. Food Chem., 2024, 72, 4, 2089–2099. https://doi.org/10.1021/acs.jafc.3c05436Yang Y.H., Xu N.H., Zhang Z.Y., Lei C.T., Chen B.F., Qin G.Y., Qiu D.Y., Lu T., Qian H.F.,* Deciphering Microbial Community and Nitrogen Fixation in the Legume Rhizosphere. J. Agric. Food Chem., 2024, 72, 5659–5670.https://doi.org/10.1021/acs.jafc.3c09160 Zhang, Z.Y., Zhang, Q., Yang, Y.H., Cui, L., Qian, H.F.,* Mining strategies for isolating plastic-degrading microorganisms, 2024, Environ. Pollut. 2024, 123572, https://doi.org/10.1016/j.envpol.2024.123572Wang, Y.,  Xu, N., Chen, B.F., Zhang, Z., Lei, C., Qian, H.,* et al., Metagenomic analysis of antibiotic-resistance genes and viruses released from glaciers into downstream habitats. (2024) Science of the Total Environment,  908, 168310Qian, H.,* Wang, Y..Predicting microbial adaptability to climate change in the Anthropocene. (2024) Global Change Biology, 30(1), e171222023Zhang, Q.,  Zhang, Z., Lei, C., Qian, H.,* et al., Metagenomic insight into the global dissemination of the antibiotic resistome. (2023) Advanced Science, 10, 2303925Chen B.F., Zhang, Z.Y., Zhang Q., Xu, N.H., Lu T., Wang, T.Z., Hong W., Fu Z.W., Penuelas J., Gillings M., Qian, H.F.,* Antimicrobial Peptides in the Global Microbiome: Biosynthetic Genes and Resistance Determinants. (2023) Environmental Science & Technology, 57, 7698-7708Xu, N., Qiu, D., Zhang, Z., Wang, Y., Chen, B., Zhang, Q., Wang, T., Hong, W., Zhou, N., Penuelas, J., Gillings, M., Zhu, Y., Qian, H.,* A global atlas of marine antibiotic resistance genes and their expression. (2023) Water Research, 244, 120488 Chen, B.F., Zhang, Z.Y., Wang, T.Z., Hu, H., Qin, G.Y., Lu, T., Hong, W.J., Hu, J., Penuelas, J., Qian, H.,* Global distribution of marine microplastics and potential for biodegradation. (2023) Journal of Hazardous Materials, 451, 131198 高被引论文Qin, G.Y., Zhang, Q., Zhang, Z.Y., Chen, Y.L., Zhu, J.C., Yang, Y.H., Peijnenburg, W.J.G.M., Qian, H.,* Understanding the ecological effects of the fungicide difenoconazole on soil and Enchytraeus crypticus gut microbiome (2023) Environmental Pollution, 326, 121518Xu, N.H., Hu, H., Wang, Y., Zhang, Z.Y., Zhang, Q., Ke, M.J., Lu, T., Penuelas J., Qian, H.F.,* Geographic patterns of microbial traits of river basins in China.  (2023)  Science of the Total Environment, 871, 162070.2022Zhang, Z.Y., Zhang, Q., Wang, T.Z., Xu, N.H., Lu, T., Hong, W.J., Penuelas, J., Gillings, M., Wang, M.X., Gao, W., Qian, H.F.,* Assessment of global health risk of antibiotic resistance genes. (2022) Nature Communications, 13, 1553. 高被引论文  Deng Y., Debognies A., Zhang Q., Zhang Z., Zhou Z., Zhang J., Sun L., Lu T., Qian H*. Effects of ofloxacin on the structure and function of freshwater microbial communities. Aquatic Toxicology. 2022, 244, 106084  高被引论文  Xu N.H.,  Zhao, Q.Q., Zhang, Zhang Z.Y., Zhang Q., Qian, H.F.,*et al., Phyllosphere Microorganisms: Sources, Drivers, and Their Interactions with Plant Hosts.  (2022) Journal of Agricultural and Food Chemistry.  80(16), 4860-4870  高被引论文 Zhang Z.Y., Zhang Q., Cui H.Z., Li Y., Xu N.H., Lu T., Chen Jian., Penuelas J., Hu B.L., Qian H.F.,* Composition identification and functional verification of bacterial community in disease-suppressive soils by machine learning. (2022) Environmental Microbiology, 24, 3405-3419  Zhang, Z.Y., Wang, Y., Chen, B., Lei, C., Yu, Y., Xu, N., Zhang, Q., Wang, T., Gao, W., Lu, T., Gillings, M. and Qian, H.* Xenobiotic pollution affects transcription of antibiotic resistance and virulence factors in aquatic microcosms. (2022) Environmental Pollution, 306, 119396.Zhang, Z.Y., Zhang, Q., Lu, T., Zhang, J., Sun, L., Hu, B., Hu, J., Peñuelas, J., Zhu, L., Qian, H.* Residual chlorine disrupts the microbial communities and spreads antibiotic resistance in freshwater (2022) Journal of Hazardous Materials, 423, 127152 2021Lu, T., Zhang, Z., Li, Y., Zhang, Q., Cui, H., Sun, L., Peijnenburg, W.J.G.M., Peñuelas, J., Zhu, L., Zhu, Y.-G., Chen, J., Qian, H.* Does biological rhythm transmit from plants to rhizosphere microbes? (2021) Environmental Microbiology, 23 (11), pp. 6895-6906Zhang, Q., Zhang, Z., Lu, T., Yu, Y., Penuelas, J., Zhu, Y.-G., Qian, H.* Gammaproteobacteria, a core taxon in the guts of soil fauna, are potential responders to environmental concentrations of soil pollutants (2021) Microbiome, 9 (1), 196Wang, Y.,  Qian, H.* Phthalates and Their Impacts on Human Health, Healthcare, 2021, 9, 603 高被引论文 Zhang, Q., Zhang, Z., Zhou, S., Jin, M., Lu, T., Cui, L., Qian, H.* Macleaya cordata extract, an antibiotic alternative, does not contribute to antibiotic resistance gene dissemination (2021) Journal of Hazardous Materials, 412, 125272 Qu, Q., Li, Y., Zhang, Z., Cui, H., Zhao, Q., Liu, W., Lu, T., Qian, H.* Effects of S-metolachlor on wheat (Triticum aestivum L.) seedling root exudates and the rhizosphere microbiome (2021) Journal of Hazardous Materials, 411, 125137 2020Qu, Q., Zhang, Z., Peijnenburg, W.J.G.M., Liu, W., Lu, T., Hu, B., Chen, J., Chen, J., Lin, Z., Qian, H.* Rhizosphere Microbiome Assembly and Its Impact on Plant Growth (2020) Journal of Agricultural and Food Chemistry, 68 (18), 5024-5038  高被引论文 Lu, T., Xu, N., Zhang, Q., Zhang, Z., Debognies, A., Zhou, Z., Sun, L., Qian, H.* Understanding the influence of glyphosate on the structure and function of freshwater microbial community in a microcosm (2020) Environmental Pollution, 260,114012Lu, T., Qu, Q., Lavoie, M., Pan, X., Peijnenburg, W.J.G.M., Zhou, Z., Pan, X., Cai, Z., Qian, H.* Insights into the transcriptional responses of a microbial community to silver nanoparticles in a freshwater microcosm (2020) Environmental Pollution, 258, 113727Zhang, Q., Zhang, Z., Lu, T., Peijnenburg, W.J.G.M., Gillings, M., Yang, X., Chen, J., Penuelas, J., Zhu, Y.-G., Zhou, N.-Y., Su, J., Qian, H.* Cyanobacterial blooms contribute to the diversity of antibiotic-resistance genes in aquatic ecosystems (2020) Communications Biology, 3 (1), 737Ke, M., Li, Y., Qu, Q., Ye, Y., Peijnenburg, W.J.G.M., Zhang, Z., Xu, N., Lu, T., Sun, L., Qian, H.* Offspring toxicity of silver nanoparticles to Arabidopsis thaliana flowering and floral development (2020) Journal of Hazardous Materials, 386, 121975 2019及以前Zhang, M., Lu, T., Paerl, H.W., Chen, Y., Zhang, Z., Zhou, Z., Qian, H.* Feedback regulation between aquatic microorganisms and the bloom-forming cyanobacterium Microcystis aeruginosa  (2019)  Applied and Environmental Microbiology, 85 (21), e01362-19Lu, T., Zhang, Q., Lavoie, M., Zhu, Y., Ye, Y., Yang, J., Paerl, H.W., Qian, H.,* Zhu, Y.-G.* The fungicide azoxystrobin promotes freshwater cyanobacterial dominance through altering competition (2019)  Microbiome, 7 (1), 128Zhang, Q., Zhu, D., Ding, J., Zheng, F., Zhou, S., Lu, T., Zhu, Y.-G., Qian, H.* The fungicide azoxystrobin perturbs the gut microbiota community and enriches antibiotic resistance genes in Enchytraeus crypticus (2019) Environment International, 131, 104965Lu, T., Zhu, Y., Ke, M., Peijnenburg, W.J.G.M., Zhang, M., Wang, T., Chen, J., Qian, H.* Evaluation of the taxonomic and functional variation of freshwater plankton communities induced by trace amounts of the antibiotic ciprofloxacin (2019) Environment International, 126, pp. 268-278Lu, T., Ke, M., Lavoie, M., Jin, Y., Fan, X., Zhang, Z., Fu, Z., Sun, L., Gillings, M., Peñuelas, J., Qian, H.,* Zhu, Y.-G.* Rhizosphere microorganisms can influence the timing of plant flowering (2018) Microbiome, 6 (1), 231Song, H., Lavoie, M., Fan, X., Tan, H., Liu, G., Xu, P., Fu, Z., Paerl, H.W., Qian, H.* Allelopathic interactions of linoleic acid and nitric oxide increase the competitive ability of Microcystis aeruginosa (2017) ISME Journal, 11 (8), pp. 1865-1876      科研成果及专利：(1) 钱海丰，白小翠，魏勇，傅正伟，一种提高三角褐指藻脂质积累的培养方法，CN201410092191.9。(2) 钱海丰，白小翠，孙冲冲，魏勇，傅正伟，Fe在缓解Cu对三角褐指藻细胞毒害中的应用，CN201410154370.0。(3) 钱海丰，丁海燕，傅正伟，无外界动力推动的离子交换树脂层析方法及装置， CN201310394008.6。(4) 钱海丰，余澍琼，傅正伟，过氧化氢在制备微囊藻毒素抑制剂中的应用，CN201110032486.3。(5) 钱海丰，丁海燕，傅正伟，无外界动力推动的离子交换树脂层析装置， CN201320542803.0。获得科技奖项：浙江省自然科学三等奖浙江省生物信息学会自然科学二等奖“十一五”浙江省自然科学基金优秀论文浙江省高校优秀科研成果奖一等奖浙江省高校优秀科研成果奖二等奖日本文部省 JSPS BRIDGEEnvironmental Science: Nano oral lecture prize  2次获得 JES杰出论文奖：多家公众号报导课题组科研成果     科研项目 主持国家级科研项目：国家重点研发项目-子课题，2022YFD1700401，2022/11-2026/12，150万，在研，主持国家自然科学基金-微塑料专项课题，22241603，2023/01-2026/12，104万，在研，主持国家自然科学基金-面上项目，22376187，2024/01-2027/12，50万，在研，主持国家自然科学基金-面上项目，21976161，2020/01-2023/12，66万，结题，主持国家自然科学基金-面上项目，21777144，2018/01-2021/12，64万，结题，主持国家自然科学基金-面上项目，21577128，2016/01-2019/12，78万，结题，主持国家自然科学基金-面上项目，21277127，2013/01-2016/12，80万，结题，主持国家自然科学基金-面上项目，21077093，2011/01-2013/12，33万，结题，主持国家自然科学基金-青年基金，20607020，2007/01-2009/12，25万，结题，主持主持省部级科研项目：浙江省自然科学基金-重点项目，LZ23B070001，2023/01-2025/12，30万，在研，主持浙江省重点研发项目-子课题，2022C02029，2022/01-2024/12，34.8万，在研，主持浙江省自然科学基金-杰出青年项目，LR14B070001，2014/01-2016/12，结题，主持浙江省钱江人才计划项目，2010R10033，2010/01-2012/12，10万，结题，主持主持国际合作科研项目：日本文部省JSPS BRIDGE项目资助（2018）结题，主持日本文部省JSPS项目资助（2012-2013），京都大学特别研究员，结题，主持参与科研项目：1.  国家重点研发计划课题，农业生物药物分子靶标发现与绿色药物分子设计，288万，2018/01-2021/12，结题，参与。2.  教育部创新团队，IRT1309，生物净化与转化，2017/01-2019/12，300万，结题，参与。 教学与课程 从事一线教学20年。获2018-2019优秀本科生导师教育部创新团队成员主持的《生命科学概论——生命·健康·安全》为2013浙江工业大学通识教育核心课程建设项目目前主讲课程：《生物化学》、《分子生态毒理学》注重课堂讨论、实验教学、科技宣传主编教材：钱海丰，裘娟萍主编。《生命科学概论》，科学出版社，2016年 育人成果 所培养的学生中，有：1人获得浙江省优秀博士论文2人获得浙江省优秀硕士论文4人获得浙江省优秀研究生毕业生15人获得研究生国家奖学金3人出国交流（比利时、澳大利亚、荷兰等）2人获得浙江省环境科学学会优秀论文一等奖10余人获得校级优秀毕业论文毕业季与学生合影    与学生一起逛街游乐 社会服务 期刊《Soil Ecology Letters 》编委受邀参与网络公开讲座，回放链接：https://m.koushare.com/video/videodetail/10705现任浙江省微生物生态专业委员会副主任委员科研成果被多次报道，包括《中国科学报》、《科技金融时报》、浙江省自然科学基金官网等 内容来自集群智慧云企服