TiezhengJia

Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us Tiezheng Jia Researcher Associate Professor Department of Chemistry Working Experience  Assistant Professor (10/2017 until now) Department of Chemistry, Southern University of Technology (SUSTech) Postdoc Researcher (03/2015-10/2017) California Institute of Technology (Caltech) Advisor: Prof. Peter B. Dervan Research: Development of Pyrrole-Imidazole Polyamides as Transcription Inhibitors in the Treatment of Myotonic Dystrophy Type I (DM1)  Education  Ph.D., Organic Chemistry (01/2012-01/2015) University of Pennsylvania Advisor: Prof. Patrick J. Walsh Thesis: Palladium-Catalyzed C-C Bond and C-S Bond Formation of Sulfoxides  M.S., Pharmaceutical Chemistry (09/2003-06/2006) Ocean University of China, Qingdao, China. Advisors: Profs. Qianqun Gu and Weiming Zhu Thesis: Bioactive Secondary Metabolites of Fungi Isolated from Marine Alga  B.S., Pharmaceutics (09/2000-06/2003) Ocean University of China, Qingdao, China. Personal Profile Personal Profile Research 1. DNA Chemical biology, anti-cancer drug development targeting mismatched base pair of DNA, cytotoxicity evaluation in cell and in vivo. 2. Development of Pyrrole-Imidazole (Py-Im) polyamides as novel chemical biology probe. 3. Novel methodology to construct high-valence sulfur-containing compounds. 4. Novel “non-catalytic” methodology development. Teaching Chemical Biology (Bachelor/Graduate) Publications Read More Research in our group primarily spans into two major branches: chemical biology and organic methodology. Our chemical biology projects are centered around DNA recognization. Non-Watson-Crick (mismatched) base pairs of DNA were considered to be the major cause of cancer, and the ratios among mismatched base pairs varied dramatically in different types of cancer cell lines. A family of synthetic peptides, namely Pyrrole-Imidazole Polyamides (PIP), is designed and synthesized to bind to mismatched base pairs in the ocean of Watson-Click base pairs with high affinity and specificity. The recognization of mismatched base pairs will be demonstrated on cancer cells and animal models in the long goal to developed bioactive peptides in the treatment of cancer. The methodology research in our group will be focused on the combination of transition-metal catalysis and main group chemistry. We develop state-of-art methods to afford molecules with main-group-containing functional group, such sulfoxides, sulfones, and sulfoximines. We are also interested in developing modern “non-catalytic” transformations. News More Dervan院士夫妇来访 2019-11-05 孟庭庭同学参加暑期学校 2019-11-04 欢送志媛，欢迎新同学 2019-11-04 People Read More PrevNext UpDown Join us We seek applications of postdoc researchers in the area of chemical biology, organic chemistry, medicinal chemistry and molecular biology. Please send your CV to jiatz@sustech.edu.cn. Read More Contact Us Contact Address Room 507, Block 5, Innovation Park, 1088 Xueyuan Avenue, Shenzhen 518055, P.R. China Office Phone 0755-88018376 Email jiatz@sustech.edu.cn