邓友超

个人简介 邓友超，特聘副教授，1990年6月生，籍贯湖南省怀化市。2016年3月，获中南大学化学化工学院制药工程专业工学硕士，师从蒋玉仁教授；2019年6月，获中南大学药学专业医学博士学位，师从沈奔教授、段燕文教授及黄勇教授；2019年8月- 2023年5月，美国普渡大学药学院，从事表观遗传靶点（甲基/乙酰基转移酶）小分子抑制剂的博士后研究工作，师从黄蓉教授。曾获国家奖学金，中南大学“优秀研究生”，中南大学“优秀博士毕业生”，“优秀博士学位论文”等荣誉称号。 研究方向：1.基于结构（SBDD）的药物设计方法研究；2.新型药物筛选技术开发；3.针对表观遗传类蛋白质靶点的小分子药物研究，如PCMT1,PARPs,PRMT以及NATs。主持中南大学博士生创新科研项目一项，中南大学校级引才支持基金一项，国家自然科学青年基金一项。近五年，以第一作者及通讯作者发表SCI收录文章10篇，其中药物化学专业顶刊6篇。 科研成果媒体报道链接： 1. The Purdue College of Pharmacy is pleased to honor and recognize the outstanding research and scholarship generated by our faculty each month. This month we highlight Drs. Youchao Deng, Postdoc in Medicinal Chemistry and Molecular Pharmacology, and Rong Huang, Professor of Medicinal Chemistry and Molecular Pharmacology, for their recent publication, " Structure–Activity Relationship Studies of Venglustat on NTMT1 Inhibition", which can be read in the Journal of Medicinal Chemistry (January, 2023; DOI: 10.1021/acs.jmedchem.2c01854). https://www.pharmacy.purdue.edu/news/2023/05/08/monthly-publication-highlight-drs-deng-and-huang 2. 普渡大学黄蓉团队报道α-N-末端甲基转移酶NTMT1的体内活性小分子抑制剂. https://www.x-mol.com/news/842346 3. 普渡大学黄蓉团队报道α-N-末端甲基转移酶的小分子抑制剂. https://www.x-mol.com/news/785483 4. 普渡大学黄蓉团队报道α-N-末端乙酰基转移酶D的新型抑制剂. https://www.x-mol.com/news/683908 5. 中南大学湘雅国际转化医学联合研究院在抗感染新药研发上取得新进展. https://news.csu.edu.cn/info/1003/139635.htm 代表性研究论文： 1. Deng Y, Song X, Iyamu ID, et al. A unique binding pocket induced by   a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta   Pharmaceutica Sinica B, 2023. (中科院一区，Top 期刊，IF 14.5) 2. Deng   Y, Deng S, Ho Y H, et al.   Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D[J]. Journal   of Medicinal Chemistry, 2021, 64: 8263-8271. (中科院一区，Top 期刊，IF 8.06)3. Dong G#, Deng   Y#, Yasgar, A, et al. Venglustat Inhibits Protein   N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner[J]. Journal   of Medicinal Chemistry, 2022, 65: 12334-12345. ( 中科院一区，Top 期刊, IF 8.06) 4. Deng Y, Weng X, Li Y, et   al. Late-stage functionalization of platensimycin leading to multiple   analogues with improved antibacterial activity in vitro and in vivo[J]. Journal   of medicinal chemistry, 2019, 62: 6682-6693. (中科院一区，Top 期刊, IF 8.06) 5. Deng Y, Su M, Kang D, et   al. Semisynthesis of platensimycin derivatives with antibiotic activities in   mice via Suzuki–Miyaura cross-coupling reactions[J]. Journal of medicinal   chemistry, 2018, 61: 11341-11348. (中科院一区，Top 期刊, IF 8.06)6. Deng   Y, Dong G, Meng   Y, et al. Structure–Activity Relationship Studies of Venglustat on NTMT1   Inhibition[J]. Journal of Medicinal Chemistry, 2023, 66: 1601–1615. (中科院一区，Top 期刊, IF 8.06) 7. Deng Y, Kang D, Shi J, et   al. The semi-synthesis, biological evaluation and docking analysis of the   oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MedChemComm,   2018, 9: 789-794.（封面, JCR Q2, IF 3.6） 8. Deng Y, Li Y, Wen Z, et   al. Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot   Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo   Activity[J]. Antibiotics, 2022, 11, 425. (JCR Q2, IF 5.2)9. Zhou,   J#, Deng Y#, et al. Comparative study of adenosine analogs as   inhibitors of protein arginine methyltransferases and a Clostridioides   difficile-specific DNA adenine methyltransferase[J]. ACS Chemical   Biology, 2023. (JCR Q1, IF 4.6)10. Al-Hamashi A A, Chen D, Deng Y,   et al. Discovery of a potent and dual-selective bisubstrate inhibitor for   protein arginine methyltransferase 4/5[J]. Acta Pharmaceutica Sinica B, 2020,   1: 2709-2718. (Top 期刊, IF 14.9)11. Cao D, Yang J, Deng Y,   et al. Discovery of a mammalian FASN inhibitor against xenografts of   non-small cell lung cancer and melanoma[J]. Signal Transduction and Targeted   Therapy, 2022, 7: 1-4. (Top 期刊, IF 38.1)12. Dong L B, Rudolf J D, Kang D, et al.   Biosynthesis of thiocarboxylic acid-containing natural products[J]. Nature   communications, 2018, 9: 1-10. (Top 期刊, IF 17.6) 联系方式： dengyouchao@csu.edu.cn; dengyouchao1206@163.com; https://scholar.google.com/citations?user=Wb8cfM4AAAAJ&hl=en; https://www.researchgate.net/profile/Youchao-Deng;