发布日期:2024-04-27 浏览次数:次
个人简介 胡忠策,浙江永嘉人,博士,教授,现任浙江工业大学钱塘生物产业研究院副院长。浙江农业大学食品系本科,浙江大学食品系硕士,浙江工业大学生物化工博士。2000年进入浙江工业大学工作,2006.7-2007.5在德国吕贝克应用技术学院工业生物技术系访学,2012年晋升为教授。坚持立德树人,兢兢业业,埋头苦干,长期从事发酵工程,生物制药领域的教学科研工作,擅长微生物基因改造与选育、发酵工艺调控和工艺放大等技术研发,取得一系列具有知识产权的工业微生物菌种,创制了多种发酵工程技术;成功研制了米格列醇、1,3-二羟基丙酮、S-腺苷蛋氨酸、虾青素、棘白菌素B、β-丙氨酸、羟化酶、脱乙酰基酶、多肽等产品的关键技术及产业化示范,取得了良好的社会与经济效应。 教学与课程 课程组负责人,主要承担本科生课程《生物工艺学原理》、研究生课程《发酵工程与技术》等教学任务。 育人成果 科研项目 1,国家重点研发计划-课题,典型药物规模化绿色生物制造工程示范(2022YFC2105404),202211-202610,主持,在研。2,国家重点研发项目,微生物化学品工厂的设计重构(2018YFA0901400),201907-202406,参与,在研。3,国家重大科学仪器设备开发专项-“高通量优选仪器开发及应用”任务13-精细化学品生物催化酶源的高通量筛选技术(编号2012YQ15008713),201210-201710,主持,已经验收。 科研成果 一,获奖 郑裕国, 胡忠策, 柳志强, 白骅, 陈正杰, 沈寅初. 1,3-二羟基丙酮微生物法生产技术开发及产业化. 中国石油和化学工业联合会, 2013年技术发明二等奖.(2/6)二,发表的论文[1]Hu Z.C., Tian Y.H., Yang J.L., Zhu Y.N., Zhou H.Y., Zheng Y.G., Liu Z.Q. * Research progress of l‑aspartate‑α‑decarboxylase and its isoenzyme in the β‑alanine synthesis. World Journal of Microbiology and Biotechnology.2023,39:42[2]Hu Z.C., Zheng C.M, Tao Y.C., Wang S.N., Wang Y.S., Liu Z.Q.* , Zheng Y.G. Improving ATP availability by sod1 deletion with a strategy of precursor feeding enhanced S-adenosyl-L-methionine accumulation in Saccharomyces cerevisiae. Enzyme and Microbial Technology. 2023,164:110189[3] Liu, D., Ke, X., Hu, Z.C.*, Zheng, Y.G. Improvement of pyrroloquinoline quinone-dependent D-sorbitol dehydrogenase activity from Gluconobacter oxydans via expression of Vitreoscilla hemoglobin and regulation of dissolved oxygen tension for the biosynthesis of 6-(N-hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose. Journal of Bioscience and Biotechnology. 2021,131(5):518-524[4] Hu, Z.C., Li, W.J., Zou, S.P., Niu, K., Zheng, Y.G*.Mutagenesis of echinocandin B overproducing Aspergillus nidulans capable of using starch as main carbon source. Prep. Biochem. Biotechnol., 2020. 50(8), 745-752.[5] Hu, Z.C., Zhao, Z.Y., Ke, X., Zheng, Y.G.* Repeated production of 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-l-sorbofuranose by immobilized Gluconobacter oxydans cells with a strategy of in situ exhaustive cell regeneration. Bioprocess and Biosystems Engineering, 2020, 43, 1781-1789[6] Liu, D., Hu, Z.C.*, Ke, X., Zheng, Y.G. Breeding of Gluconobacter oxydans with high PQQ-dependent D-sorbitol dehydrogenase for improvement of 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose production. Biochemical Engineering Journal, 2020, 161,107642[7]Liu, D., Ke, X., Hu, Z.C.*, Zheng, Y.G. Combinational expression of D-sorbitol dehydrogenase and pyrroloquinoline quinone increases 6-(N-hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose production by Gluconobacter oxydans through cofactor manipulation, Enzyme Microb. Tech. 2020, 141:109670[8] Hu, Z.C., Bu, J.L., Wang, R.Y., Ke, X., Zheng, Y.G.* 2019. Enhanced Production of 6-(N-Hydroxyethyl)-Amino-6-Deoxy--L-Sorbofuranose by Immobilized Gluconobacter oxydans on Corn Stover with a pH Control Strategy in a Bubble Column Bioreactor. Applied Biochemistry And Biotechnology, 2019,188(2), 297-309 社会服务