郑晶

个人简介 郑晶，女，湖南大学化学化工学院教授，博士生导师，岳麓学者，湖南省青年科技人才。研究方向为生物传感分析。主要开展了荧光、表面增强拉曼等功能化分子探针的设计、制备及其在生化分析与传感方面的应用研究。主持国家自然科学基金项目3项，省部级项目8项。Email: zhengjing2013@hnu.edu.cn

教育背景

教育背景 2003/09-2007/06              湖南大学化学化工学院，本科，导师：王柯敏 教授    2007/09-2015/04              湖南大学/ University of Florida (美国)，联合培养博士研究生，导师：杨荣华 教授 ； 谭蔚泓 教授

工作履历

工作履历 2015/05-2016/11              湖南大学化学化工学院，化学系，助理教授 2016/12-2022/12              湖南大学化学化工学院，化学系，副教授 2023/01-至今                    湖南大学化学化工学院，化学系，教授

研究领域

科研项目 [1] 2021-2024年，国家自然科学基金面上项目，功能化球形核酸用于胶质瘤缺氧相关信号通路分子的传感分析及肿瘤治疗研究(22074035)，65万，主持。 [2] 2018-2021年,  国家自然科学基金面上项目，神经退行性疾病相关长链非编码RNA的高灵敏检测及功能调控基础研究(21775037), 65万, 主持。 [3] 2015-2017年,  国家自然科学基金青年项目，胰岛β细胞 miRNA信号放大检测新方法研究 (21405038), 25万, 主持。 [4] 2020-2022年，化学生物传感与计量学国家重点实验室交叉前沿项目，新型维生素K2衍生物的合成及其用于抗膀胱癌联合免疫应答分析，30万，主持。 [5] 2021-2022年，广东省生物医学信息检测与超声成像重点实验室开放课题，功能化纳米探针用于缺氧微环境的成像分析及高效治疗，6万，主持。

学术成果

学术成果 科研论文 [1] Dingwen Yu, Jinfeng Yang, Lijuan Wang, Mingjian Chen, Ronghua Yang, Jing Zheng*. Engineering a dual-responsive, exosome-surface anchored DNA nanosensor for microenvironment monitoring in vivo. Chem. Commun., 2022, 58, 3661-3664. [2] Sheng-Yan Yin, Yingcai Hu, Jing Zheng*, Jishan Li*, Ronghua Yang. Tannic acid-assisted biomineralization strategy for encapsulation and intracellular delivery of protein drugs. ACS Applied Materials & Interfaces, 2022, 14, 50583-50591. [3] Shiya Chen, Yibo Zhou, Sheng Yang, Ronghua Yang, Quan Yuan, Jing Zheng*. Design and engineering of hypoxia and acidic pH dual-stimuli-responsive intelligent fluorescent nanoprobe for precise tumor imaging. Small 2021, 17, 2100243-2100253. [4] Jin Liu, Le Yang, Caoye Xue, Ge Huang, Shiya Chen, Jing Zheng*. Reductase and light programmatical gated DNA nanodevice for spatiotemporally controlled imaging of biomolecules in subcellular organelles under hypoxic conditions. ACS Applied Materials & Interfaces 2021, 13, 33894-33904. [5] Jin Liu, Ge Ding, Shiya Chen, Caoye Xue, Mian Chen,* Xu Wu,* Quan Yuan, Jing Zheng*. ACS Appl. Mater. Interfaces., 2021, 13, 9681-9690. [6] Shiya Chen, Dingwen Yu, Wen Zhong, Jin Liu, Jun Liu*, Bo Liu*, Jing Zheng*. Visualization of O2/ATP cross-talk in living cells with a smart fluorescent nanoprobe. Chem. Commun., 2021, 57, 7786-7789. [7] Shiya Chen, Jin Liu, YinhuiLi, Xu Wu, QuanYuan, Ronghua Yang, Jing Zheng*. Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy. Trends in Analytical Chemistry, 2020, 131, 116010-116016. [8] Le Yang, Jing Zheng, Zhen Zou,* Haiyan Cai, Peng Qi, Weihong Tan, Ronghua Yang.* Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma. Chemical Communications, 2020, 56, 1843-1846. (共同第一作者) [9] Na Liu, Zhen Zou, Jin Liu, Cong Zhu, Jing Zheng*. A fluorescent nanoprobe based on azoreductase-responsive metal– organic frameworks for imaging VEGF mRNA under hypoxic conditions. Analyst, 2019, 144, 6254-6261. [10] Caixia Huang, Jing Zheng,* Dandan Ma, Na Liu, Cong Zhu, Jishan Li, Ronghua Yang. Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy. Journal of Materials Chemistry B, 2018, 6, 6424-6430. [11] Caixia Huang, Wenlong Tan, Jing Zheng,* Cong Zhu, Jia Huo,* Ronghua Yang. Azoreductase-responsive metal-organic framework-based nanodrug for enhanced cancer therapy via breaking hypoxia induced chemoresistance. ACS Applied Materials & Interfaces, 2019, 11, 25740-25749. [12] Dandan Ma, Caixia Huang, Jing Zheng,* Wenyu Zhou, Jianru Tang, Weiju Chen, Jishan Li, Ronghua Yang*. Azoreductase-responsive nanoprobe for hypoxia-induced mitophagy imaging. Analytical Chemistry, 2019, 91, 1360-1367. [13] Cong Zhu, Zhen Zou, Caixia Huang, Jing Zheng,* Na Liu, Jishan Li, Ronghua Yang. Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes. Chemical Communications, 2019, 55, 3235-3238. [14] Cong Zhu, Jinfeng Yang, Jing Zheng,* Shiya Chen, Fujian Huang,* Ronghua Yang. Triplex-functionalized DNA tetrahedral nanoprobe for imaging of intracellular pH and tumor-related messenger RNA. Analytical Chemistry, 2019, 91, 24, 15599-15607. [15] Dandan Ma, Caixia Huang, Jing Zheng,* Jianru Tang, Jishan Li, Jinfeng Yang, Ronghua Yang. Quantitative detection of exosomal microRNA extracted from human blood based on surface-enhanced Raman scattering. Biosensors and Bioelectronics. 2018, 101, 167-173. [16] Jianru Tang, Caixia Huang, Jinyong Shu, Jing Zheng,* Dandan Ma, Jishan Li, Ronghua Yang. Azoreductase and target simultaneously activated fluorescent monitoring for cytochrome c release under hypoxia. Analytical Chemistry, 2018, 90, 5865-5872. [17] Dandan Ma, Caixia Huang, Jing Zheng,* Jianru Tang, Jishan Li, Jinfeng Yang, Ronghua Yang. Quantitative detection of exosomal microRNA extracted from human blood based on surface-enhanced Raman scattering. Biosensors and Bioelectronics. 2018, 101, 167-173. [18] Pinting Tang, Jing Zheng*, Jianru Tang, Dandan Ma, Weijian Xu, Jishan Li, Ronghua Yang. Programmable DNA triple-helix molecular switch in biosensing: From homogenous solution to living cells. Chemical Communications, 2017, 53, 2507-2510. [19] Jianru Tang, Dandan Ma, Stevan Pecic, Caixia Huang, Jing Zheng,* Jishan Li, Ronghua Yang.* Noninvasive and highly selective monitoring of intracellular glucose via a two-step recognition-based nanokit. Analytical Chemistry, 2017, 89, 16, 8319-8327.  [20] Qifeng Zhou, Jing Zheng*, Sheng Yang, Le Ying, Ronghua Yang*. Detection of circulating tumor DNA in human blood via DNA-mediated surface-enhanced Raman spectroscopy of single-walled carbon nanotubes. Analytical Chemistry, 2016, 88, 4759-4765. [21] Jing Zheng, Ronghua Yang*, Xiaohong Fang, Weihong Tan*. Rationally designed molecular beacons for bioanalytical and biomedical applications. Chemical Society Reviews, 2015, 44, 3036-3055. [22] Zhehua Zhang, Yue Xiao, Yinhui Li, Jing Zheng*, Ronghua Yang*. Silver nanoparticle-gated mesoporous silica-coated gold nanorods (AuNR@MS@AgNPs): Low premature release and multifunctional cancer theranostic platform. ACS Applied Materials & Interfaces, 2015, 7, 6211-6219.  [23] Lili Wang, Jing Zheng*, Yinhui Li, Ronghua Yang*. Two-photon sensing and imaging of endogenous biological cyanide in plant tissues using graphene quantum dot/gold nanoparticle conjugate. ACS Applied Materials & Interfaces, 2015, 7, 19509-19515. [24] Jing Zheng, Dandan Ma, Jinfeng Yang, Ronghua Yang*. A new enzyme-free quadratic SERS signal amplification approach for circulating microRNA detection in human serum. Chemical Communications, 2015, 51,16271-16274. [25] Muling Shi, Jing Zheng, Yongjun Tan, Ronghua Yang*. Ultrasensitive detection of single nucleotide polymorphism in human mitochondrial DNA utilizing ion-mediated cascade SERS amplification. Analytical Chemistry, 2015, 87, 2734-2740. (共同第一作者) [26] Jia Tao, Peng Zhao, Jing Zheng*, Ronghua Yang*. Electrochemical detection of type 2 diabetes mellitus-related SNP via DNA-mediated growth of silver nanoparticles on single walled carbon nanotubes. Chemical Communications, 2015, 51, 15704-15707. [27] Jing Zheng, Yuhong Nie, Yinhui Li, Ronghua Yang.* Remote-controlled release of DNA in living cells via simultaneous light and host-guest mediations. Analytical Chemistry, 2014, 86, 10208-10214.  [28] Jing Zheng, Yaping Hu, Ronghua Yang*, Weihong Tan. Universal surface-enhanced Raman scattering amplification detector for ultrasensitive detection of multiple target analytes. Analytical Chemistry, 2014, 86, 2205-2212. [29] Lili Wang, Jing Zheng, Yinhui Li, Ronghua Yang*. AgNP-DNA@GQDs hybrid: New approach for sensitive detection of H2O2 and glucose via simultaneous AgNP etching and DNA cleavage. Analytical Chemistry, 2014, 86, 12348-12354. (共同第一作者) [30] Jing Zheng, Guizhi Zhu, Ronghua Yang*, Weihong Tan*. A multifunctional spherical nucleic acid-conjugate platform based on self-assembled DNA biopolymer for high perform cancer therapy. ACS Nano, 2013, 7, 6545-6554. [31] Jing Zheng, Yuhong Nie, Jishan Li, Ronghua Yang*. Time-resolved fluorescent detection of Hg2+ in a complex environment by conjugating magnetic nanoparticles with a triple-helix molecular switch. Chemical Communications, 2013, 49, 6915-6917. [32] Anli Jiao, Jing Zheng, Ronghua Yang*, Weihong Tan. Hybridization-triggered isothermal signal amplification coupled with MutS for label-free and sensitive fluorescent assay of SNPs. Chemical Communications, 2012, 48, 5659-5661.(共同第一作者） [33] Jing Zheng, Anli Jiao, Ronghuang Yang*, Weihong Tan*. Fabricating a reversible and regenerable Raman-active substrate with a biomolecule-controlled DNA nanomachine. Journal of the American Chemical Society, 2012, 134, 19957-19960. [34] Jing Zheng, Jishan Li, Ronghua Yang*, Weihong Tan. Design of aptamer-based sensing platform using triple-helix molecular switch. Analytical Chemistry, 2011, 83, 6586-6592. [35] Jing Zheng, Jishan Li, Xiaoxia Gao, Ronghua Yang*, Weihong Tan. Modulating molecular level space proximity: a simple and efficient strategy to design structured DNA probes. Analytical Chemistry, 2010, 82, 3914-3921.科研著作 科研专利成果 软件著作权