王子龙

教师主页 团队成员 科研项目 研究领域 学术成果 教学 科研分享 新闻动态 疼痛医学中心 成果介绍 软件 毕业去向 加入我们 联系我们 王子龙 Google Scholar 助理教授 医学院, 医学神经科学系 王子龙，南方科技大学医学院助理教授，博士生导师。本科毕业于兰州大学生物学人才培养基地，2017年获得兰州大学-杜克大学联合培养博士学位。随后在杜克大学进行博士后研究。王子龙长期致力于痛觉和痒觉的分子细胞和神经机制研究，以及镇痛或止痒药物的研发。以第一或通讯作者（含共同）在Science Translational Medicine、Brain、Neuron、Gastroenterology、Cell Discovery、J Med Chem.、Anesthesiology等国际期刊上发表SCI 论文18篇，以合作作者在Nature、Neuron（3篇）、Journal of clinical investigation、Nature communications（2篇）等国际期刊上发表SCI 论文30篇，总共发表SCI论文47篇；被引大于1700次，H-index为22。以主要发明人申请国家发明专利8件（已授权5件），美国专利2件，国际专利PCT 3件。 ●教育背景 2007.09 – 2011.06，兰州大学，学士，生物科学 2011.09 – 2017.06，兰州大学，博士，生物化学与分子生物学 2016.01 – 2017.01，杜克大学，联合培养博士，神经学系  ●工作经历 2017.01 – 2017.10，杜克大学医学院，访问学生，麻醉学系 2017.10 – 2021.01，杜克大学医学院，博士后，麻醉学系 2021.03 –至今， 南方科技大学医学院，助理教授、博士生导师 个人简介 王子龙，南方科技大学医学院助理教授，博士生导师。本科毕业于兰州大学生物学人才培养基地，2017年获得兰州大学-杜克大学联合培养博士学位，随后在杜克大学进行博士后研究，2021年加入南方科技大学医学院。王子龙长期致力于痛觉和痒觉的分子细胞和神经机制研究，以及镇痛或止痒药物的研发。已发表相关领域SCI论文49篇，其中以第一作者或通讯作者发表论文17篇，包括“Science Translational Medicine”、“Brain”、“Gastroenterology”、“Neuron”等高水平杂志。另外本人作为主要发明人申请中国国家发明专利9项，已获授权5项；申请国际专利PCT 3项，美国专利2项。 研究领域 病理性疼痛及瘙痒的分子神经机制研究及新型镇痛或止痒药物研发。主要研究方向包括： （1）痛觉及痒觉的神经机制及新靶点的发现； （2）免疫-神经相互作用； （3）病理性疼痛的细胞分子机制研究及其临床治疗新药新技术研发； （4）阿片类药物镇痛及其副作用的细胞分子以及神经环路机制； （5）镇痛或止痒药物研发。 教育背景 2007.09 – 2011.06，兰州大学学士，生物科学专业 2011.09 – 2017.06，兰州大学-杜克大学联合培养博士，生物化学与分子生物学专业 工作经历 2017.10 – 2021.01，杜克大学医学院，博士后研究员 2021.03 – 至今，南方科技大学医学院，助理教授、博士生导师 获奖情况及荣誉 2021年 广东省高层次人才 2021年 深圳市海外高层次人才 2017年 兰州大学优秀毕业生 2015年 国家奖学金   近年代表文章 #co-first author, *corresponding author. 2024 49.  Ximin Chi#*, Yiming Chen#, Yaning Li#, Lu Dai#, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yang, Zilong Wang*, Renhong Yan*. Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.  Science Advances, 2024, 10, eadl3685 48. Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahan, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, and Ru-Rong Ji*. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. The Journal of Clinical Investigation, 2024, 134(9):e173537. 47. Songqiang Huang#, Wanting Dong#, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian1. Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity, 2024, in press. 46. Leyan Shan#, Kangtai Xu#, Luyao Ji#, Qian Zeng#, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang *, and Zilong Wang * . Injured sensory neurons-derived Galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, Behavior, and Immunity, 2024, in press. 2023 45. Yaning Li#, Yiming Chen#, Yuanyuan Zhang#, Yaping Shen#, Kangtai Xu, Yaqi Liu, Zilong Wang* and Renhong Yan*, Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1. Cell Discovery, 2023, 9:93 44. Fabiana C Dias#, Zilong Wang#, Garrett Scapellato and Yong Chen*, Silencing of TRPV4-expressing sensory neurons attenuates temporomandibular disorders pain. Molecular Pain, 2023, 19: 1–6. 43. K. Xu, Y. Wu, Z. Tian, Y. Xu, C. Wu*, and Z. Wang*, Microglial Cannabinoid CB(2) Receptors in Pain Modulation. Int J Mol Sci, 2023. 24(3). 42. L. Li, P. Li, J. Guo, Y. Wu, Q. Zeng, N. Li, X. Huang, Y. He, W. Ai, W. Sun, T. Liu, D. Xiong, L. Xiao, Y. Sun, Q. Zhou, H. Kuang, Z. Wang*, and C. Jiang*, Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain. Br J Pharmacol, 2023. 180(13): p. 1730-1747. 2022 41. Qiaojuan Zhang, Fabiana Dias, Quan Fang, Gwendolyn Henry, Zilong Wang, Abbie Suttle, and Yong Chen, Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. Acta dermato-venereologica, 2022. 102: p. adv00651-adv00651. 40. Vivian Lei, Chelsea Handfield, Jeffery T. Kwock, Stephen J. Kirchner, Min Jin Lee, Margaret Coates, Kaiyuan Wang, Qingjian Han, Zilong Wang, Jennifer G. Powers, Sarah Wolfe, David L. Corcoran, Brian Fanelli, Manoj Dadlani, Ru-Rong Ji, Jennifer Y. Zhang, and Amanda S. MacLeod, Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. The Journal of investigative dermatology, 2022. 2021 39. Junli Zhao, Alexus Roberts, Zilong Wang, Justin Savage, and Ru-Rong Ji, Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neuroscience Bulletin, 2021. 37(8): p. 1188-1202. 38. Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, Maria Lioudyno, Qian Zeng, Peng Wang, Zilong Wang, Jorge Busciglio, Ru-Rong Ji, and Wolfgang Liedtke, Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. Nature Communications, 2021. 12(1). 37. Zilong Wang* and Zhen-Zhong Xu, The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain. Neuroscience Bulletin, 2021. 37(7): p. 1079-1081. 36. Zilong Wang#*, Changyu Jiang#, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, and Ru-Rong Ji, Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. Brain, 2021. 144: p. 665-681. 35. Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, and Ru-Rong Ji, IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron, 2021. 109(17): p. 2691-+. 34. Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S. Lee, Yu L. Lei, William Maixner, Mei-Chuan Ko, and Ru-Rong Ji, STING controls nociception via type I interferon signalling in sensory neurons. Nature, 2021. 591(7849): p. 275-+. 33. Yong Chen#, Zi-Long Wang#, Michele Yeo, Qiao-Juan Zhang, Ana E. Lopez-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lazaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, and Wolfgang Liedtke, Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology, 2021. 161(1): p. 301-+. 32. Sangsu Bang, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, and Ru-Rong Ji, Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. Nature Communications, 2021. 12(1). 2020 31. Biao Xu, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, Yu Qiu, Ting Zhang, Kangtai Xu, Xiaoyu Zhang, Wolfgang Liedtke, Rui Wang, and Quan Fang, The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu- and kappa-opioid receptors. British Journal of Pharmacology, 2020. 177(1): p. 93-109. 30. Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, and Quan Fang, Spinal DN-9, a Peptidic Multifunctional Opioid/Neuropeptide FF Agonist Produced Potent Nontolerance Forming Analgesia With Limited Side Effects. Journal of Pain, 2020. 21(3-4): p. 477-493. 29. Zilong Wang#, Changyu Jiang#, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan Wang, Sangsu Bang, Huiping Ding, Mei-Chuan Ko, and Ru-Rong Ji, Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Science Translational Medicine, 2020. 12(531). 28. Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, and Seok-Yong Lee, Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 2020. 105(5): p. 882-+. 27. Changyu Jiang, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, and Ru-Rong Ji, PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia. Iscience, 2020. 23(10). 26. Sharat Chandra#, Zilong Wang#, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov, Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology, 2020. 133(3): p. 611-627. 2019 25. Ting Zhang, Zhenglan Han, Xuerui Shi, Weidong Zhao, Zilong Wang, Run Zhang, Biao Xu, Mengna Zhang, Qinqin Zhang, Jian Xiao, Hanwen Zhu, Ting Zheng, and Quan Fang, Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation. Bioorganic & Medicinal Chemistry, 2019. 27(4): p. 630-643. 24. Zilong Wang, Christopher R. Donnelly, and Ru-Rong Ji, Scratching after Stroking and Poking: A Spinal Circuit Underlying Mechanical Itch. Neuron, 2019. 103(6): p. 952-954. 2018 23. Chao Chen, Biao Xu, Xuerui Shi, Mengna Zhang, Qinqin Zhang, Ting Zhang, Weidong Zhao, Run Zhang, Zilong Wang, Ning Li, and Quan Fang, GpTx-1 and Ala(5), Phe(6), Leu(26), Arg(28) GpTx-1, two peptide Na(V)1.7 inhibitors: analgesic and tolerance properties at the spinal level. British Journal of Pharmacology, 2018. 175(20): p. 3911-3927. 22. Sangsu Bang, Ya-Kai Xie, Zhi-Jun Zhang, Zilong Wang, Zhen-Zhong Xu, and Ru-Rong Ji, GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. Journal of Clinical Investigation, 2018. 128(8): p. 3568-3582. 21. Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen, and Quan Fang, Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. Journal of Neuroinflammation, 2018. 15. 20. Qingjian Han, Di Liu, Marino Convertino, Zilong Wang, Changyu Jiang, Yong Ho Kim, Xin Luo, Xin Zhang, Andrea Nackley, Nikolay V. Dokholyan, and Ru-Rong Ji, miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. Neuron, 2018. 99(3): p. 449-+. 2017 19. Ting Zheng, Ting Zhang, Run Zhang, Zi-Long Wang, Zheng-Lan Han, Ning Li, Xu-Hui Li, Meng-Na Zhang, Biao Xu, Xiong-Li Yang, Quan Fang, and Rui Wang, Pharmacological characterization of rat VD-hemopressin(alpha), an alpha-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice. Neuropeptides, 2017. 63: p. 83-90. 18. Run Zhang, Biao Xu, Meng-na Zhang, Ting Zhang, Zi-long Wang, Geng Zhao, Guang-hai Zhao, Ning Li, Quan Fang, and Rui Wang, Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. European Journal of Pharmacology, 2017. 813: p. 122-129. 2016 17. Hong-ping Yu, Nan Zhang, Ting Zhang, Zi-long Wang, Ning Li, Hong-hai Tang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway. Peptides, 2016. 86: p. 24-32. 16. Zi-Long Wang, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang, and Rui Wang, Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities. Journal of Medicinal Chemistry, 2016. 59(22): p. 10198-10208. 15. Zi-long Wang#, Ning Li#, Pei Wang, Hong-hai Tang, Zheng-lan Han, Jing-jing Song, Xu-hui Li, Hong-ping Yu, Ting Zhang, Run Zhang, Biao Xu, Meng-na Zhang, Quan Fang, and Rui Wang, Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance. Neuropharmacology, 2016. 108: p. 364-372. 14. X. H. Li, M. L. Lin, Z. L. Wang, P. Wang, H. H. Tang, Y. Y. Lin, N. Li, Q. Fang, and R. Wang, Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice. Neurogastroenterology and Motility, 2016. 28(6): p. 891-899. 13. Ning Li, Zheng-lan Han, Zi-long Wang, Yan-hong Xing, Yu-long Sun, Xu-hui Li, Jing-jing Song, Ting Zhang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice. British Journal of Pharmacology, 2016. 173(11): p. 1864-1880. 12. Yong Chen, Quan Fang, Zilong Wang, Jennifer Y. Zhang, Amanda S. MacLeod, Russell P. Hall, and Wolfgang B. Liedtke, Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. Journal of Biological Chemistry, 2016. 291(19): p. 10252-10262. 2015 11. Jia-Xin Pan#, Zi-Long Wang#, Ning Li, Nan Zhang, Pei Wang, Hong-Hai Tang, Ting Zhang, Hong-Ping Yu, Run Zhang, Ting Zheng, Quan Fang, and Rui Wang, Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice. European Journal of Pharmacology, 2015. 767: p. 119-125. 10. Zheng-lan Han, Zi-long Wang, Xu-hui Li, Ning Li, Jia-xin Pan, Ting Zheng, Quan Fang, and Rui Wang, Neuropeptide VF Enhances Cannabinoid Agonist WIN55,212-2-Induced Antinociception in Mice. Anesthesia and Analgesia, 2015. 121(5): p. 1360-1368. 2014 9. Wangsheng Sun, Liang Hong, Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni, and Rui Wang, An Organocatalytic Michael-Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters. Organic Letters, 2014. 16(2): p. 544-547. 8. Jia-Xin Pan, Zi-Long Wang, Ning Li, Zheng-Lan Han, Xu-Hui Li, Hong-Hai Tang, Pei Wang, Ting Zheng, Quan Fang, and Rui Wang, Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(alpha) and WIN55,212-2 at the supraspinal level in mice. Neuroscience Letters, 2014. 578: p. 187-191. 7. Xu-hui Li, Ning Li, Zi-long Wang, Jia-xin Pan, Zheng-lan Han, Xue-mei Chang, Hong-hai Tang, Pei Wang, Rui Wang, and Quan Fang, The hypotensive effect of intrathecally injected (m) VD-hemopressin(alpha) in urethane-anesthetized rats. Peptides, 2014. 56: p. 45-51. 6. Zheng-lan Han#, Quan Fang#, Zi-long Wang, Xu-hui Li, Ning Li, Xue-mei Chang, Jia-xin Pan, Hong-zhu Tang, and Rui Wang, Antinociceptive Effects of Central Administration of the Endogenous Cannabinoid Receptor Type 1 Agonist VDPVNFKLLSH-OH (m)VD-hemopressin(alpha) , an N-Terminally Extended Hemopressin Peptide. Journal of Pharmacology and Experimental Therapeutics, 2014. 348(2): p. 316-323. 5. Zi-long Wang#, Quan Fang#, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei Wang, Ting Zheng, Xue-mei Chang, and Rui Wang, Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice. Plos One, 2014. 9(8). 2013 4. Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, and Rui Wang, Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behavioural Brain Research, 2013. 248: p. 51-56. 3. Xin Liu, Yuan Wang, Yanhong Xing, Jing Yu, Hong Ji, Ming Kai, Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, and Rui Wang, Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent mu-Opioid Agonists. Journal of Medicinal Chemistry, 2013. 56(7): p. 3102-3114. 2012 2. Ning Li, Zheng-lan Han, Quan Fang, Zi-long Wang, Hong-zhu Tang, Hui Ren, and Rui Wang, Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behavioural Brain Research, 2012. 233(2): p. 428-433. 1. Quan Fang, Zheng-Lan Han, Ning Li, Zi-Long Wang, Ning He, and Rui Wang, Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology, 2012. 62(2): p. 855-864. 个人简介 研究领域 痛觉和痒觉的分子细胞和神经机制研究及药物研发。 主要研究方向包括： （1）阿片类药物镇痛及其副作用的细胞分子以及神经环路机制； （2）镇痛或止痒药物研发； （3）痛觉及痒觉的神经机制及新靶点的发现； （4）免疫-神经相互作用； （5）病理性疼痛的细胞分子机制研究及其临床治疗新药新技术研发。 教学 生理学与病理生理学（本科） 疼痛医学（研究生） 学术成果 查看更多 #co-first author, *corresponding author. 2024 49.  Ximin Chi#*, Yiming Chen#, Yaning Li#, Lu Dai#, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yang, Zilong Wang*, Renhong Yan*. Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.  Science Advances, 2024, 10, eadl3685 48. Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahan, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, and Ru-Rong Ji*. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. The Journal of Clinical Investigation, 2024, 134(9):e173537. 47. Songqiang Huang#, Wanting Dong#, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian1. Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity, 2024, in press. 46. Leyan Shan#, Kangtai Xu#, Luyao Ji#, Qian Zeng#, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang *, and Zilong Wang * . Injured sensory neurons-derived Galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, Behavior, and Immunity, 2024, in press. 2023 45. Yaning Li#, Yiming Chen#, Yuanyuan Zhang#, Yaping Shen#, Kangtai Xu, Yaqi Liu, Zilong Wang* and Renhong Yan*, Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1. Cell Discovery, 2023, 9:93 44. Fabiana C Dias#, Zilong Wang#, Garrett Scapellato and Yong Chen*, Silencing of TRPV4-expressing sensory neurons attenuates temporomandibular disorders pain. Molecular Pain, 2023, 19: 1–6. 43. K. Xu, Y. Wu, Z. Tian, Y. Xu, C. Wu*, and Z. Wang*, Microglial Cannabinoid CB(2) Receptors in Pain Modulation. Int J Mol Sci, 2023. 24(3). 42. L. Li, P. Li, J. Guo, Y. Wu, Q. Zeng, N. Li, X. Huang, Y. He, W. Ai, W. Sun, T. Liu, D. Xiong, L. Xiao, Y. Sun, Q. Zhou, H. Kuang, Z. Wang*, and C. Jiang*, Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain. Br J Pharmacol, 2023. 180(13): p. 1730-1747. 2022 41. Qiaojuan Zhang, Fabiana Dias, Quan Fang, Gwendolyn Henry, Zilong Wang, Abbie Suttle, and Yong Chen, Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. Acta dermato-venereologica, 2022. 102: p. adv00651-adv00651. 40. Vivian Lei, Chelsea Handfield, Jeffery T. Kwock, Stephen J. Kirchner, Min Jin Lee, Margaret Coates, Kaiyuan Wang, Qingjian Han, Zilong Wang, Jennifer G. Powers, Sarah Wolfe, David L. Corcoran, Brian Fanelli, Manoj Dadlani, Ru-Rong Ji, Jennifer Y. Zhang, and Amanda S. MacLeod, Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. The Journal of investigative dermatology, 2022. 2021 39. Junli Zhao, Alexus Roberts, Zilong Wang, Justin Savage, and Ru-Rong Ji, Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neuroscience Bulletin, 2021. 37(8): p. 1188-1202. 38. Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, Maria Lioudyno, Qian Zeng, Peng Wang, Zilong Wang, Jorge Busciglio, Ru-Rong Ji, and Wolfgang Liedtke, Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. Nature Communications, 2021. 12(1). 37. Zilong Wang* and Zhen-Zhong Xu, The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain. Neuroscience Bulletin, 2021. 37(7): p. 1079-1081. 36. Zilong Wang#*, Changyu Jiang#, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, and Ru-Rong Ji, Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. Brain, 2021. 144: p. 665-681. 35. Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, and Ru-Rong Ji, IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron, 2021. 109(17): p. 2691-+. 34. Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S. Lee, Yu L. Lei, William Maixner, Mei-Chuan Ko, and Ru-Rong Ji, STING controls nociception via type I interferon signalling in sensory neurons. Nature, 2021. 591(7849): p. 275-+. 33. Yong Chen#, Zi-Long Wang#, Michele Yeo, Qiao-Juan Zhang, Ana E. Lopez-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lazaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, and Wolfgang Liedtke, Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology, 2021. 161(1): p. 301-+. 32. Sangsu Bang, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, and Ru-Rong Ji, Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. Nature Communications, 2021. 12(1). 2020 31. Biao Xu, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, Yu Qiu, Ting Zhang, Kangtai Xu, Xiaoyu Zhang, Wolfgang Liedtke, Rui Wang, and Quan Fang, The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu- and kappa-opioid receptors. British Journal of Pharmacology, 2020. 177(1): p. 93-109. 30. Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, and Quan Fang, Spinal DN-9, a Peptidic Multifunctional Opioid/Neuropeptide FF Agonist Produced Potent Nontolerance Forming Analgesia With Limited Side Effects. Journal of Pain, 2020. 21(3-4): p. 477-493. 29. Zilong Wang#, Changyu Jiang#, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan Wang, Sangsu Bang, Huiping Ding, Mei-Chuan Ko, and Ru-Rong Ji, Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Science Translational Medicine, 2020. 12(531). 28. Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, and Seok-Yong Lee, Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 2020. 105(5): p. 882-+. 27. Changyu Jiang, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, and Ru-Rong Ji, PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia. Iscience, 2020. 23(10). 26. Sharat Chandra#, Zilong Wang#, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov, Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology, 2020. 133(3): p. 611-627. 2019 25. Ting Zhang, Zhenglan Han, Xuerui Shi, Weidong Zhao, Zilong Wang, Run Zhang, Biao Xu, Mengna Zhang, Qinqin Zhang, Jian Xiao, Hanwen Zhu, Ting Zheng, and Quan Fang, Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation. Bioorganic & Medicinal Chemistry, 2019. 27(4): p. 630-643. 24. Zilong Wang, Christopher R. Donnelly, and Ru-Rong Ji, Scratching after Stroking and Poking: A Spinal Circuit Underlying Mechanical Itch. Neuron, 2019. 103(6): p. 952-954. 2018 23. Chao Chen, Biao Xu, Xuerui Shi, Mengna Zhang, Qinqin Zhang, Ting Zhang, Weidong Zhao, Run Zhang, Zilong Wang, Ning Li, and Quan Fang, GpTx-1 and Ala(5), Phe(6), Leu(26), Arg(28) GpTx-1, two peptide Na(V)1.7 inhibitors: analgesic and tolerance properties at the spinal level. British Journal of Pharmacology, 2018. 175(20): p. 3911-3927. 22. Sangsu Bang, Ya-Kai Xie, Zhi-Jun Zhang, Zilong Wang, Zhen-Zhong Xu, and Ru-Rong Ji, GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. Journal of Clinical Investigation, 2018. 128(8): p. 3568-3582. 21. Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen, and Quan Fang, Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. Journal of Neuroinflammation, 2018. 15. 20. Qingjian Han, Di Liu, Marino Convertino, Zilong Wang, Changyu Jiang, Yong Ho Kim, Xin Luo, Xin Zhang, Andrea Nackley, Nikolay V. Dokholyan, and Ru-Rong Ji, miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. Neuron, 2018. 99(3): p. 449-+. 2017 19. Ting Zheng, Ting Zhang, Run Zhang, Zi-Long Wang, Zheng-Lan Han, Ning Li, Xu-Hui Li, Meng-Na Zhang, Biao Xu, Xiong-Li Yang, Quan Fang, and Rui Wang, Pharmacological characterization of rat VD-hemopressin(alpha), an alpha-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice. Neuropeptides, 2017. 63: p. 83-90. 18. Run Zhang, Biao Xu, Meng-na Zhang, Ting Zhang, Zi-long Wang, Geng Zhao, Guang-hai Zhao, Ning Li, Quan Fang, and Rui Wang, Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. European Journal of Pharmacology, 2017. 813: p. 122-129. 2016 17. Hong-ping Yu, Nan Zhang, Ting Zhang, Zi-long Wang, Ning Li, Hong-hai Tang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway. Peptides, 2016. 86: p. 24-32. 16. Zi-Long Wang, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang, and Rui Wang, Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities. Journal of Medicinal Chemistry, 2016. 59(22): p. 10198-10208. 15. Zi-long Wang#, Ning Li#, Pei Wang, Hong-hai Tang, Zheng-lan Han, Jing-jing Song, Xu-hui Li, Hong-ping Yu, Ting Zhang, Run Zhang, Biao Xu, Meng-na Zhang, Quan Fang, and Rui Wang, Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance. Neuropharmacology, 2016. 108: p. 364-372. 14. X. H. Li, M. L. Lin, Z. L. Wang, P. Wang, H. H. Tang, Y. Y. Lin, N. Li, Q. Fang, and R. Wang, Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice. Neurogastroenterology and Motility, 2016. 28(6): p. 891-899. 13. Ning Li, Zheng-lan Han, Zi-long Wang, Yan-hong Xing, Yu-long Sun, Xu-hui Li, Jing-jing Song, Ting Zhang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice. British Journal of Pharmacology, 2016. 173(11): p. 1864-1880. 12. Yong Chen, Quan Fang, Zilong Wang, Jennifer Y. Zhang, Amanda S. MacLeod, Russell P. Hall, and Wolfgang B. Liedtke, Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. Journal of Biological Chemistry, 2016. 291(19): p. 10252-10262. 2015 11. Jia-Xin Pan#, Zi-Long Wang#, Ning Li, Nan Zhang, Pei Wang, Hong-Hai Tang, Ting Zhang, Hong-Ping Yu, Run Zhang, Ting Zheng, Quan Fang, and Rui Wang, Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice. European Journal of Pharmacology, 2015. 767: p. 119-125. 10. Zheng-lan Han, Zi-long Wang, Xu-hui Li, Ning Li, Jia-xin Pan, Ting Zheng, Quan Fang, and Rui Wang, Neuropeptide VF Enhances Cannabinoid Agonist WIN55,212-2-Induced Antinociception in Mice. Anesthesia and Analgesia, 2015. 121(5): p. 1360-1368. 2014 9. Wangsheng Sun, Liang Hong, Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni, and Rui Wang, An Organocatalytic Michael-Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters. Organic Letters, 2014. 16(2): p. 544-547. 8. Jia-Xin Pan, Zi-Long Wang, Ning Li, Zheng-Lan Han, Xu-Hui Li, Hong-Hai Tang, Pei Wang, Ting Zheng, Quan Fang, and Rui Wang, Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(alpha) and WIN55,212-2 at the supraspinal level in mice. Neuroscience Letters, 2014. 578: p. 187-191. 7. Xu-hui Li, Ning Li, Zi-long Wang, Jia-xin Pan, Zheng-lan Han, Xue-mei Chang, Hong-hai Tang, Pei Wang, Rui Wang, and Quan Fang, The hypotensive effect of intrathecally injected (m) VD-hemopressin(alpha) in urethane-anesthetized rats. Peptides, 2014. 56: p. 45-51. 6. Zheng-lan Han#, Quan Fang#, Zi-long Wang, Xu-hui Li, Ning Li, Xue-mei Chang, Jia-xin Pan, Hong-zhu Tang, and Rui Wang, Antinociceptive Effects of Central Administration of the Endogenous Cannabinoid Receptor Type 1 Agonist VDPVNFKLLSH-OH (m)VD-hemopressin(alpha) , an N-Terminally Extended Hemopressin Peptide. Journal of Pharmacology and Experimental Therapeutics, 2014. 348(2): p. 316-323. 5. Zi-long Wang#, Quan Fang#, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei Wang, Ting Zheng, Xue-mei Chang, and Rui Wang, Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice. Plos One, 2014. 9(8). 2013 4. Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, and Rui Wang, Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behavioural Brain Research, 2013. 248: p. 51-56. 3. Xin Liu, Yuan Wang, Yanhong Xing, Jing Yu, Hong Ji, Ming Kai, Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, and Rui Wang, Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent mu-Opioid Agonists. Journal of Medicinal Chemistry, 2013. 56(7): p. 3102-3114. 2012 2. Ning Li, Zheng-lan Han, Quan Fang, Zi-long Wang, Hong-zhu Tang, Hui Ren, and Rui Wang, Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behavioural Brain Research, 2012. 233(2): p. 428-433. 1. Quan Fang, Zheng-Lan Han, Ning Li, Zi-Long Wang, Ning He, and Rui Wang, Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology, 2012. 62(2): p. 855-864. 新闻动态 更多新闻 南科大医学院王子龙团队与南山医院蒋昌宇团队合作揭示了感觉神经元来源的Galectin-3通过小胶质细胞调控神经病理性疼痛 2024-01-11 南科大医学院鄢仁鸿/王子龙团队合作解析SLC6家族异源氨基酸转运蛋白复合物的结构与功能 2023-09-12 团队成员 查看更多 PrevNext UpDown 加入团队 南方科技大学医学院王子龙课题组招聘博士后Postdoctoral Researchers 2名 课题组简介王子龙，南方科技大学医学院助理教授(Tenure-track A/P)，独立课题组长，博士生导师。2017年获得兰州大学博士学位。2017-2021年在杜克大学进行博士后研究。本课题组长期致力于痛觉和痒觉的分子细胞和神经机制研究，以及镇痛或止痒药物的研发。相关成果发表在 “Science Translational Medicine”、“Brain”、“Gastroenterology”、“Neuron”等高水平杂志。课题组的研究方向包括：（1）痛觉及痒觉的神经机制及新靶点的发现；（2）痛觉痒觉相关免疫-神经相互作用；（3）癌性、糖尿病性、化疗、神经损伤等所致病理性疼痛的细胞分子机制研究及其临床治疗新药新技术研发；（4）阿片类药物镇痛及其副作用的细胞分子以及神经环路机制。（5）离子通道相关的镇痛或止痒药物研发。 申请人主要研究领域和学术背景要求 生物学、医学相关研究背景；神经生物学、神经药理学、神经免疫学，具有痛觉或痒觉研究经验或动物行为学、膜片钳电生理、计算机辅助药物设计等研究经验者优先考虑。 基本要求1、已获得相关专业全日制博士学位，且获得博士学位时间一般不超过2 年。具有扎实的专业知识、研究技能和独立开展科学研究的能力，具有优秀的科学研究训练和实践记录。2、热爱科学并对神经科学研究或神经疾病药物充满兴趣，具有良好的团队合作精神。3、具有良好的英语写作能力和中英文交流能力。 岗位待遇 1、博士后聘用期两年，年薪33万元起，含广东省生活补助15万元及深圳市生活补助6万元，并按深圳市有关规定参加社会保险及住房公积金。博士后福利费参照学校教职工标准发放。2、特别优秀候选人可以申请校长卓越博士后，年薪可达41万元以上（含广东省及深圳市补助）。3、在站期间，可依托学校申请深圳市公租房，未依托学校使用深圳市公租房的博士后，可享受两年税前2800元/月的住房补贴。4、拥有优良的工作环境和境内外合作交流机会，博士后在站期间享受两年共计2.5万学术交流经费资助。 申请材料 详细的个人简历，含学习、工作和科研的经历，主要科研成果（论文、专利、论著等），以及其他可以证明工作能力的材料。至少提供2 名推荐人的姓名及有效联系方式。 请申请者讲上述材料整合为单个PDF 文件发送。 应聘方式 应聘者请将以上应聘材料整合为单个PDF，发至邮箱wangzl6@sustech.edu.cn，收到邮件后我们会尽快回复，并邀请面试。本招聘公告长期有效，期待加盟！  查看更多 联系我们 联系地址 广东省深圳市南山区学苑大道1088号慧园5栋309 办公电话 0755-8801 0526 电子邮箱 wangzl6@sustech.edu.cn