陈浩

教师主页 团队成员 科研项目 研究领域 学术成果 教学 科研分享 新闻动态 疼痛医学中心 成果介绍 软件 毕业去向 加入我们 联系我们 陈浩 助理教授 |医学院 陈浩，南方科技大学医学院博士生导师，分别于武汉大学生物学基地班和复旦大学生物医学研究院获得本科和博士学位，2015年2月至2019年12月在哈佛医学院进行博士后训练，2020年加入南方科技大学。研究方向为肿瘤及代谢类疾病（糖尿病、肥胖等）发生的表观遗传学机制，本课题组使用生物化学技术，结合多组学方法，鉴定和研究新型RNA/DNA表观遗传学修饰酶的分布模式和生物学功能；同时，致力于开发新的表观研究技术，探索表观遗传学修饰失调引起各类疾病发生的分子机制，寻找治疗癌症及各种代谢类疾病的表观遗传学靶点。  近年来一直从事解析新型RNA/DNA表观遗传学修饰调节异常促进疾病发生的分子机制。近年来取得多项成果：1）对RNA修饰进行系统性研究，发现多种新型RNA修饰酶，其中包括METTL4 (Nature Communications，2022，Cell Research, 2020; Cell Discovery, 2020)；METTL5 (EMBO Reports, 2020; bioRxiv, 2020); METTL15 (JBC, 2020); ZCCH4 (NCB,2019 ), PCIF1(Mol Cell,2019), METTL3/14 (Nature, 2017); 2）阐明糖尿病导致的糖代谢异常促进肿瘤发生的分子机制（Nature，2018; Cell Research, 2019）；3）通过分析影响表观遗传核心蛋白稳定性的调节因子，揭示外界刺激如何信号传导通路调控表观遗传学建立及维持的新机制（PNAS，2012；MCB，2013）。  至今(2023年3月），已发表研究论文共计25篇，其中，以一作（含共一）或共同通讯作者身份在Nature，Cell Research，Nature Communications,EMBO Reports等杂志发表论文11篇。关于糖尿病表观遗传学修饰紊乱促使肿瘤发生的研究工作，发表于Nature和Cell Research杂志，获得Nature Reviews Cancer等多个权威杂志的专文评论，围绕METTL4的研究工作标记为F1000推荐论文。同时，获得了广东省“珠江人才”青年拔尖人才、深圳市“孔雀计划”海外高层次人才等项目资助，并分别以项目负责人和子课题负责人身份承担国家自然科学基金委面上项目和国家重点研发计划各一项。 个人简介 个人简介 研究领域 1. 肿瘤及代谢类疾病（糖尿病及肥胖等）发生的表观遗传学机制; 2. mRNA翻译机制和mRNA药物开发。 教学 医学表观遗传学（本科生） Advanced biological sciences (Postgraduate) 医学表观遗传学前沿（研究生） 学术成果 查看更多 Publications (Since 2020 @SUSTech): #co-first, *co-corresponding (1) Meijie Qi ; Haifeng Sun ; Yueshuai Guo ; Yu Zhou ; Xueying Gu ; Jiachuan Jin ; Xiaoxu Chen ; Fangzhu Wang;  Honghui Ma ; Xuejiang Guo*; Hao Chen*; Bin Shen*; m(6)A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts, Cell Proliferation,2022, 55(1): e13164 (2) Qiang Luo# ; Jiezhen Mo# ; Hao Chen# ; Zetao Hu ; Baihui Wang ; Jiabing Wu ; Ziyu Liang ; Wenhao Xie ; Kangxi Du ; Maolin Peng ; Yingping Li ; Tianyang Li ; Yangyi Zhang ; Xiaoyan Shi ; Wen-Hui Shen ; Yang Shi ; Aiwu Dong ; Hailin Wang ; Jinbiao Ma ; Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4, Nature Comunications, 2022,13(1): 5636 (3) Dingdang Yu; Guoyu Chen; Yuci Wang; Yining Wang; Risheng Lin; Nanbo Liu; Ping Zhu; Hang Liu; Tao Hu; Rui Feng; Haizhong Feng; Fei Lan; Jiabin Cai*; Hao Chen*; Regulation of cohesin‐mediated chromosome folding by PDS5 in mammals, EMBO reports, 2022, 23(11): e54853 (4) Shuhong Han; Jihong Liu; Mianhuan Li; Yizhou Zhang; Xiangke Duan; Yingdan Zhang; Hao Chen; Zhao Cai; Liang Yang; Yang Liu ; DNA Methyltransferase Regulates Nitric Oxide Homeostasis and Virulence in a Chronically Adapted Pseudomonas aeruginosa Strain, MSystems, 2022, 7(5) (5) Liudan Jiang ; Jiayong Yin ; Maoxiang Qian ; Shaoqin Rong ; Shengqi Zhang ; Kejing Chen;Chengchen Zhao ; Yuanqing Tan ; Jiayin Guo ; Hao Chen ; Siyun Gao ; Tingting Liu ; Yi Liu ; Bin Shen ;  Jian Yang ; Yong Zhang ; Fei-Long Meng ; Jinchuan Hu ; Honghui Ma ; Yi-Han Chen ; UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution, Journal of the American Chemical Society, 2022,144(3): 1323-1331       (6) Shujie Chen,; Lu Zhang; Mengjie Li; Ying Zhang; Meng Sun; Lingfang Wang; Jiebo Lin; Yun Cui; Qian Chen; Chenqi Jin; Xiang Li; Boya Wang; Hao Chen; Tianhua Zhou; Liangjing Wang; Chih-Hung Hsu; Wei Zhuo ; Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis, Nature Communications, 2022, 13(1)   (7) Siyun Gao; Haifeng Sun; Kejing Chen; Xueying Gu; Hongyu Chen; Liudan Jiang; Lei Chen; Shengqi Zhang; Yi Liu; Dan Shi; Dandan Liang; Liang Xu; Jian Yang; Yanjiao Ruan; Hao Chen; Bin Shen; Honghui Ma; Yi‐Han Chen ; Depletion of m 6 A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin, Journal of Cellular and Molecular Medicine, 2021, 25(23): 10879-10891 (8) Yasen Maimaitiyiming; Qian Qian Wang; Chang Yang; Yasumitsu Ogra; Yinjun Lou; Clayton A. Smith; Liaqat Hussain; Yi Ming Shao; Jiebo Lin; Jinfeng Liu; Lingfang Wang; Yong Zhu; Haiyan Lou; Yuan Huang; Xiaoxia Li; Kao-Jung Chang; Hao Chen; Hongyan Li; Ying Huang; Eric Tse; Jie Sun; Na Bu; Shih-Hwa Chiou; Yan Fang Zhang; Hao Ying Hua; Li Ya Ma; Ping Huang; Ming Hua Ge; Feng-Lin Cao; Xiaodong Cheng; Hongzhe Sun; Jin Zhou; Vasilis Vasliou; Pengfei Xu; Jie Jin; Mikael Bjorklund; Hong-Hu Zhu; Chih-Hung Hsu; Hua Naranmandura ; Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins, Blood Cancer Discovery, 2021, 2(4): 388-401   (9) Ming Xing ; Qi Liu ; Cong Mao ; Hanyi Zeng ; Xin Zhang ; Shuqin Zhao ; Li Chen ; Mingxi Liu ; Bin Shen ; Xuejiang Guo ; Honghui Ma*; Hao Chen*; Jun Zhang* ; The 18S rRNA m 6 A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation, EMBO reports, 2020, 21(10): e49863   Publications (Before 2020): #co-first, *co-corresponding (1)Di Wu # ; Di Hu # ; Hao Chen # ; Guo-Ming Shi #; Irfete S. Fetahu ; Feizhen Wu ; Kimberlie Rabidou ;Rui Fang ; Li Tan ; Shuyun Xu ; Hang Liu ; Christian Argueta ; Lei Zhang ; Fei Mao ; Guoquan Yan ; Jiajia Chen ; Zhao-Ru Dong ; Ruitu Lv ; Yufei Xu ; Mei Wang ; Yong Ye ; Shike Zhang ; Danielle Duquette ; Songmei Geng ; Clark Yin ; Arash Mostaghimi ; George F. Murphy ; Gail K. Adler ; Rajesh Garg ; Lydia   Lynch ; Pengyuan Yang ; Yiming Li ; Fei Lan ; Jia Fan ; Yang Shi ; Yujiang Geno Shi ; Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Nature, 2018,559(7715): 637-641      (2) Lei Gu#; Longfei Wang# ; Hao Chen# ; Jiaxu Hong# ; Zhangfei Shen ; Abhinav Dhall ; Taotao Lao ; Chaozhong Liu ; Zheng Wang ; Yifan Xu ; Hong-Wen Tang ; Damayanti Chakraborty ; Jiekai Chen ; Zhihua Liu ; Dragana Rogulja ; Norbert Perrimon ; Hao Wu ; Yang Shi ; CG14906 (mettl4) mediates m6Amethylation of U2 snRNA in Drosophila, Cell Discovery, 2020, 6(1): 44    (3) Hao Chen; Dingdang Yu; Rui Fang; Kimberlie Rabidou; Di Wu; Di Hu; Peilin Jia; Zhongming Zhao; Zhiping Wu; Junmin Peng; Yang Shi; Yujiang Geno Shi ; TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer, Cell Research, 2019,29(3): 248-250     (4) Hao Chen# ; Lei Gu#; Esteban A. Orellana; Yuanyuan Wang; Jiaojiao Guo; Qi Liu; Longfei Wang; Zhangfei Shen; Hao Wu; Richard I. Gregory; Yi Xing; Yang Shi ; METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing, Cell Research, 2020, 30(6): 544-547 (5) Hao Chen# ; Zhennan Shi# ; Jiaojiao Guo# ; Kao-jung Chang ; Qianqian Chen ; Cong-Hui Yao ; Marcia C. Haigis ; Yang Shi ; The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function, Journal of Biological Chemistry, 2020, 295(25): 8505-8513    (6) Honghui Ma# ; Hao Chen# ; Xue Guo#; Zhentian Wang ; Mathew E. Sowa ; Lijuan Zheng ; Shibin Hu ; Pingyao Zeng ; Rui Guo ; Jianbo Diao ; Fei Lan ; J. Wade Harper ; Yujiang Geno Shi ; Yanhui Xu ; Yang Shi ; M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical  association with the deubiquitylase USP7 and stability, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 13(109): 4828-4833      (7) Hao Chen ; Honghui Ma ; Hiroyuki Inuzuka ; Jianbo Diao ; Fei Lan ; Yujiang Geno Shi ; Wenyi  Wei ; Yang Shi ; DNA Damage Regulates UHRF1 Stability via the SCF -TrCP E3 Ligase, Molecular and Cellular Biology, 2013, 33(6): 1139-1148     (8) Erdem Sendinc ; David Valle-Garcia ; Abhinav Dhall ; Hao Chen; Telmo Henriques ; José      Navarrete-Perea ; Wanqiang Sheng ; Steven P. Gygi ; Karen Adelman ; Yang Shi ; PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression, Molecular Cell, 2019, 75(3): 620-630.e9     (9) Wanqiang Sheng ; Martin W. LaFleur ; Thao H. Nguyen ; Sujun Chen ; Ankur Chakravarthy ; Jake Conway ; Ying Li ; Hao Chen ; Henry Yang ; Pang-Hung Hsu ; Eliezer M. Van Allen ; Gordon J. Freeman ;  Daniel D. De Carvalho ; Housheng Hansen He ; Arlene H. Sharpe ; Yang Shi ; LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade, Cell, 2018, 174(3): 549-563.e19       (10) Yu-Ru Lee; Ming Chen; Jonathan D. Lee; Jinfang Zhang; Shu-Yu Lin; Tian-Min Fu; Hao Chen; Tomoki Ishikawa; Shang Yin Chiang; Jesse Katon; Yang Zhang; Yulia V. Shulga; Assaf C. Bester; Jacqueline Fung; Emanuele Monteleone; Lixin Wan; Chen Shen; Chih-Hung Hsu; Antonella Papa; John G. Clohessy; Julie Teruya-Feldstein; Suresh Jain; Hao Wu; Lydia E. Matesic; Ruey-Hwa Chen; Wenyi Wei; Pier Paolo Pandolfi ; Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway, Science, 2019, 364(6441)      加入团队 查看更多 联系我们 联系地址 广东省深圳市学苑大道1088号南方科技大学医学院 办公电话 0755-88015592 电子邮箱 chenh7@sustech.edu.cn