高学娟

导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 高学娟 部门： 生命科学技术学院 直属机构： 生化与分子生物学系（生命与健康工程研究院） 性别： 女 职称： 副研究员 学位： 博士 毕业院校： 华南师范大学 联系电话： 02085223139 电子邮箱： tgaoxj@jnu.edu.cn 办公地址： 暨南大学第二理工楼915A 通讯地址： 广州市天河区暨南大学第二理工楼915A 邮编： 510631 联系方式 个人简介 高学娟博士, 副研究员，硕士生导师。2003年于河南医科大学临床医学系获得本科学位，2003年至2009年在华南师范大学激光生命教育部重点实验室硕博连读，2009年至今，任职于暨南大学生命科学技术学院，生命与健康工程研究院生物化学与分子生物学系。研究方向主要围绕功能蛋白质在恶性肿瘤发生发展中的生物学功能和作用机制、抗癌药物的作用机理。相关研究结果已经在《Sci. Rep.》、《Aging-US》、《J. Cell. Physiol.》、《Apoposis》、《J. Biomed. Sci.》、《Cell Cycle》、《Int. J. Cancer》、《J. Cell. Biochem.》、《Biochem. Cell Biol.》、《J. Mol. Biol.》等国际一流刊物上发表SCI收录论文30余篇，其中11篇为第一作者，6篇为通讯作者。应邀为«Lasers Med. Sci.»、«J. X-RAY Sci. Technol. »、«中国临床药理学与治疗学»期刊审稿。主持国家自然科学基金青年项目1项、广东省自然科学基金项目1项、广州市科技计划1项、暨南大学创新与培育基金3项，作为第二负责人参与国家自然科学基金多项，以及广东省自然科学基金多项。  学习经历 学习经历：2003-2009：华南师范大学，硕博连读，细胞生物学1998-2003：河南医科大学，学士学位，临床医学  工作经历 工作经历：2009-至今，暨南大学生物化学与分子生物学系（生命与健康工程研究院），副研究员  主要论文 1.第一作者论文（1）Xuejuan Gao#., Junxia Feng#., Yujiao He#., Fengmei Xu., Xiaoqin Fan., Wensi Huang., Haiting Xiong., Qiuyu Liu., Wanting Liu., Xiaohui Liu., Xuesong Sun., Qing-Yu He., Qihao Zhang*., Langxia Liu*, hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells, Sci. Rep, 2016, 6:22999.（2）Xuejuan Gao#., Fengmei Xu#., Huan-Tian Zhang., Miaojuan Chen., Wensi Huang., Qihao Zhang., Qingzhong Zeng., Langxia Liu*, PKCα/GSK3b/NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis, Biochem Cell Biol.,2016, 94(3):256-264.（3）Xuejuan Gao#., Songsong Dan#., Yingying Xie., Huanhuan Qin., Donge Tang., Xiaohui Liu., Qing-Yu He., Langxia Liu*,14-3-3ζ reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen,J Cell Biochem,2015,116(1):158-169. doi: 10.1002/jcb.24955（4）Cuihua Wang#., Xuejuan Gao#., Shengyou Liao., Junxia Feng., Bin Luo., Langxia Liu*, Transcriptome analysis of human breast cancer cell lines MCF-7 and MDA-MB-435 by RNA-Seq, Molecular Biology, 2015, 49(2):244-252.（5）Xuejuan Gao#., Yujiao He#., Ling-Mei Gao., Junxia Feng., Yingying Xie., Xiaohui Liu., Langxia Liu*, Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner,Biochem Cell Biol,2014, 92(5):349-56.doi: 10.1139/bcb-2014-0065.（6）Xuejuan Gao#., Junxia Feng#., Sen Zhu., Xiaohui Liu., Isabelle Tardieux., Langxia Liu*, Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis, Biomed Environ Sci,2014, 27(11):883-93. doi: 10.3967/bes2014.130.（7）Miaojuan Chen#., Xuejuan Gao#., Lina Xu., Tengfei Liu., Xiaohui Liu.,Langxia Liu*, Ezrin is required for epithelial-mesenchymal transition induced by TGF-β1 in A549 cells, Int J Oncol, 2014,45(4):1515-22. doi: 10.3892/ijo.2014.2554.（8）Xuejuan Gao#., Jian-Ying Wang#., Ling-Mei Gao., Xing-Feng Yin., Langxia Liu*, Identification and analysis of glycogen synthase kinase 3 beta1 interactome, Cell Biol Int, 2013, 37(8):768-779（9）Xuejuan Gao., Da Xing*.，Lei Liu.，Yonghong Tang, H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low power laser irradiation. Journal of Cellular Physiology, 2009, 219: 535–543（10）Xuejuan Gao., Da Xing*, Molecular mechanisms of cell proliferation induced by low power laser irradiation. Journal of Biomedical Science, 2009, 16:4, doi:10.1186/1423-0127-16-4（11）Xuejuan Gao., Da Xing*., Yihui Pei., Fang Wang, Dynamic activation of H-Ras induced by low power laser irradiation in living cells, Proc SPIE. 2007, 6534, 65341D-1-8 (EI indexed).（12）Xuejuan Gao., Tongsheng Chen., Da Xing*., Fang Wang., Yihui Pei., Xunbin Wei, Single Cell Analysis of PKC Activation During Proliferation and Apoptosis Induced by Laser Irradiation. Journal of Cellular Physiology, 2006, 206:441–448 （13）Xuejuan Gao., Da Xing*., Tongsheng Chen, Dynamic interaction between 14-3-3zeta and Bax during TNF-alpha-induced apoptosis in living cells, Proc. SPIE, 2006, 6047, 6047371-6 (EI indexed).（14）Xuejuan Gao., Fang Wang., Da Xing*, Molecular Imaging of Low-Power Laser Irradiation Induced Cell Proliferation, Proc SPIE,2006,6087, 60870N-1-12 (EI indexed). （15）Xuejuan Gao., Tongsheng Chen., Da Xing*., and Fang Wang, Imaging of Protein Kinase C Activation by FRET During Proliferation Induced by Low-Energy Laser Irradiation in Living Cells, Proc SPIE,2005, 5630, 593-598 (EI indexed).2.通讯作者论文 （1）Zeng QZ, Liu WT, Lu JL, Liu XH, Zhang YF, Liu LX*, Gao XJ*. YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated Osteosarcoma Cell Proliferation. Biomed Environ Sci. 2018 Mar;31(3):186-196. doi: 10.3967/bes2018.024.（2）Huang WS, Xu FM, Zeng QZ, Xiaohui Liu, Xuejuan Gao *, Langxia Liu *, ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells. Biomed Environ Sci. 2017, 30(7):473-481.（3）Xiaoqin Fan#., Jinmei Wei#., Haiting Xiong., Xiaohui Liu., Serge Benichou*., Xuejuan Gao*., Langxia Liu*, A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction, Int J Oncol,2015, 47(4): 1485-1493.3.  参与论文（1）Li Z, Liu X, Ma J, Zhang T, Gao X, Liu L. hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells. Int J Oncol. 2018 Nov;53(5):2200-2212. doi: 10.3892/ijo.2018.4517.（2）Liang GH, Liu N, He MT, Yang J, Liang ZJ, Xuejuan Gao, Rahhal AH, He QY, Zhang HT, Zha ZG, Transcriptional regulation of Runx2 by HSP90 controls osteosarcoma apoptosis via the AKT/GSK-3β/β-catenin signaling. J. Cell. Biochem., 2017, doi: 10.1002/jcb.26260.（3）Zhang HT, Yang J, Liang GH, Xuejuan Gao, Sang Y, Gui T, Liang ZJ, Tam MS, Zha ZG, Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF-1/SOX9 Axis. J. Cell. Biochem., 2017, 118:4575-4586.（4）Jia HL, Liu CW, Zhang L, Xu WJ, Xuejuan Gao, Bai J, Xu YF, Xu MG, Zhang G, Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease. Sci. Rep., 2017, 7:44706.（5）Xiaoqin Fan#., Haiting Xiong#., Jinmei Wei., Xuejuan Gao., Yuan Feng., Xiaohui Liu., 承担课题 1.广东省自然科学基金项目,2018A030313544,TRIM21通过调控自噬抑制骨肉瘤细胞分化的分子机制,2018/5/1-2021/4/30,10万，主持2.广州市科技计划项目科学（技术）研究专项一般项目，201707010263，hnRNPK调节α-tubulin乙酰化与Hippo通路交叉对话进而调控肿瘤增殖的分子机制研究，2017/5/1-2020/4/30，20万，主持3.暨南大学创新与培育基金跃升计划项目，21615407，GSK3β与hnRNPK的相互作用参与调节TRAIL诱导的肿瘤细胞凋亡，2015/1/1—2016/12/31，12万，主持4.国家自然科学基金面上项目，31271607，重金属镉暴露影响子代睾丸Leydig细胞发育的线粒体相关机制研究，2013/01-2016/12，75万，已结题，参加5. 国家自然科学基金青年项目,21310037，GSK3β调控肿瘤细胞凋亡分子机制的研究，2011/01-2013/12，21万元，已结题，主持    讲授课程