暨南大学

徐石海

发布日期:2024-04-08 浏览次数:

导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名: 徐石海 部门: 化学与材料学院 直属机构: 实验技术中心 性别: 男 职务: 主任 职称: 教授 学位: 博士 毕业院校: 中山大学 联系电话: 13070263778 电子邮箱: txush@jnu.edu.cn 办公地址: 广州市,暨南大学分析测试中心203房 通讯地址: 广州市,暨南大学分析测试中心203房 邮编: 510632 荣誉奖励: 国家级青年人才 联系方式 固定电话:02085227796移动电话:13070263778微信号:xu13070263778QQ:879887173 个人简介 湖南隆回人,教授,博士,博士生导师。研究简介一直从事海洋生物活性成分研究,先后主持国家十五“863”课题“海藻中抗肿瘤和治疗心血管疾病活性化合物的分离与鉴定(No. 2001AA628100,2004AA628030)”和十一五“863”课题 “珊瑚中抗肿瘤活性化合物的分离与结构鉴定(No. 2006AA09Z408))”、国家自然科学基金课题“抗肿瘤海洋生物碱的研究(No. 20002001)”和“Ircinia属海绵中抗肿瘤活化合物的发现与优化(No. 20772048)”和广东省自然科学基金课题、广东省科技计划课题、广东省自然资源厅课题和广州市科技计划课题等二十余项课题,通过这些项目的完成,从海洋生物品种海藻、珊瑚、海绵中分离鉴定从我国南海各种海洋生物品种中分离鉴定1500多种海洋天然产物,其中300余种为首次发现的新化合物,这些化合物的分属于萜类、生物碱、甾醇、神经酰胺、脂肪酸,糖类。对具有自主知识产权的且生物活性较强的4个海洋生物碱、一个二糖酯与一个环肽化合物进行全合成,并进行结构修饰得到100多个修饰化合物。在国内外权威学术期刊,如:Organic Letters,British Journal of Pharmacology,Journal of Natural Products,Steroids,Marine Drugs等期刊上发表学术论文200余篇,申请国内专利20项,授权15项。 学习经历 1993/09-1996/07, 中山大学,化学系,博士1990/09-1993/07, 湘潭大学,化学系,硕士1985/09-1988/06,湖南邵阳学院,化学系,大学 工作经历 研究工作经历2002/10-现在,暨南大学化学与材料学院,化学系,教授,博士生导师 2008/03-2008/09,美国密西西比大学,药学院生药系做高级访问学者 1998/10-2002/10, 暨南大学生命科学与技术学院,化学系,副教授; 1996/07-1998/10, 暨南大学理工学院,化学系,讲师 研究方向 1、海洋药物化学的分离:从海藻、珊瑚、海绵等海洋生物及共附生微生物中分离海洋药物活性先导化合物;2、海洋药物全合成:对具有自主知识产权的活性化合物进行全合成、结构修饰及规模化制备;3、药物活性筛选、成药性评价及应用:活性化合物进行于化妆品、药物及材料等开发。 主要论文 1、Liang, YongQian; Liao, XiaoJian; Zhao, BingXin* and Xu, Shihai*,Novel 3,4-seco-3,19- dinorspongian and 5,17-epoxy-19-norspongian diterpenes from the marine spongeSpongiasp., Organic Chemistry Frontiers, 2020, 7,3253–3261.2、Lin, Xiao; Zhou,Yongjun; Liu,Liyun; Zhu, Hongrui;Chen,Yeping;Wang,Shuping; Sun,Fan; Chai, Ling; Liu, Buming; Xu, Shihai* and Hou-Wen Lin*, Compound Discovery and Structure-Activity Relationship Study of Neoantimycins Against Drug-Resistant Cancer Cells, Frontiers in Chemistry, 2019,7(481),1-10.3、Jiao, FuRong; Gu, BinBin; Zhu, HongRui; Zhang,Yun; Liu,Ke Chun;  Zhang,Wei;Han, Hua *;Xu, Shihai* and Hou-Wen Lin*, Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1, The Journal of Organic Chemistry,2020,doi.org/10.1021/acs.joc.0c020494、Chen, Shengtian; Wang, Junfeng; Lin, Xiuping; Zhao, Bingxin; Wei, Xiaoyi; Li, Guangqiang; Kaliaperumal, Kumaravel; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Liu, Juan; Xu, Shihai*; Liu, Yonghong*, Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001, Organic Letters, 2016, 18(15): 3650-3653.5、Xu, WenJie; Liao, XiaoJian; Xu, ShiHai*; Diao, JianZhong; Du, Bin; Zhou, XuLong; Pan, Shan-Shan,Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa,Organic Letters, 2008, 10(20): 4569-4572.6、Xiong, Sheng; Pang, Hui-dan,Fan, Jun,Ge, Feng,Yang, Xiaoxia,Liu, Qiuying,Liao, Xiaojian,Xu, Shihai*,In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action,British Journal of Pharmacology,2010, 159(4): 909-918.7、Ding, LiJian; Yuan, Wei; Liao, XiaoJian; Han, BingNan; Wang, ShuPing; Li, ZhiYong; Xu, ShiHai*; Zhang, Wei*; Lin, HouWen*, Oryzamides A-E, Cyclodepsipeptides from the Sponge-Derived Fungus Nigrospora oryzae PF18, Journal of Natural Products,2016, 79(8): 2045-2052.8、Li, DaiChun; Yang,Yan; Zhang, Bing; Liao, Xiao Jian; Jiang, ZhiHui; Xu, ShiHai*and Zhao, BingXin*, Three New Butenolides from the Green Alga Caulerpa racemosavar. Turbinata,Chem. Biodiversity , 2020, 17, e2000022,1-69、Liu,TingTing; Liao, XiaoJian; Xu, ShiHai*and Zhao, BingXin*, Solieritide A, a new polyketide from the red alga Solieriasp.,Natural Product Research,2020,3,1-710、Guana, ZhuoBin; Liang, Yong Qian; Lin, JiaLi; Liao, XiaoJian; Xu, ShiHai*and Zhao, BingXin*, Two new pyrrolidine alkaloids from the red alga Acanthophora spicifera,Natural Product Research,2020,3,1-711、Pang, Xiaoyan;Lin, Xiuping; Zhou, Xuefeng;Yang, Bin; Tian, Xinpeng;Wang, Junfeng*;Xu, ShiHai*; Yonghong Li*, New quinoline alkaloid and bisabolane-type sesquiterpenoid derivatives from the deep-sea-derived fungus Aspergillus sp. SCSIO06786,Fitoterapia,2020,104406,(140),1-512、Liang, Yong Qian; Liao, Xiao Jian; Lin, Jia Li; Xu, Wei; Chen, Guo Dong*; Zhao, Bing Xin*; Xu, Shi Hai*,Spongiains A-C: Three new spongian diterpenes with ring A rearrangement from the marine sponge Spongiasp.,Tetrahedron, 2019, 75(27): 3802-3808. 13、Pang, Xiaoyan; Cai, Guodi; Lin, Xiuping; Salendra, Limbadri; Zhou, Xuefeng; Yang, Bin; Wang, Junjian; Wang, Junfeng*; Xu, Shihai*; Liu, Yonghong*,New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 ,Marine Drugs,2019, 17(7): 0-398.14、Ding, Lijian; Ren, Lu; Li, Shuang; Song, Jingjing; Han, Zhiwen; He, Shan*; Xu, Shihai*, Production of New Antibacterial 4-Hydroxy-alpha-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium,Marine Drugs,2019, 17(6): 1-8.  15、Zhang, Jun*; Ling, Wei; Yang, Zhiqiang; Liang, Yan; Zhang, Linyan; Guo, Can; Wang, Kailing; Zhong, Balian; Xu,Shihai*; Xu, Ying*, Isolation and Structure-Activity Relationship of Subergorgic Acid and Synthesis of Its Derivatives as Antifouling Agent,Marine Drugs, 2019, 17(2): 1-11. 16、Lai, Wei; Qin, Sheng Ying; Zou, Ge; Liao, Xiao Jian; Chen, Guo Dong; Zhang, Hua; Zhao, Bing Xin*;Xu, Shi Hai*,Sinulaspirolactam A, a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral Sinularia sp.,Journal of Asian Natural Products Research, 2019, 21(5): 494-501.17、Sun, Yueguang; Li, Hang bin; Zhou, Rong; Wang, Hailin; Feng, Pengju*; Xu, Shihai*,Total Synthsis of Thermoactionamide andIts Analogue,Heterocycles, 2019, 98(6): 789-797. 18、Lunagariya, Jignesh; Bhadja, Poonam; Zhong, Shenghui; Vekariya, Rohit; Xu, Shihai*,Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology,Mini Reviews in Medicinal Chemistry, 2019, 19(9): 751-761. 19、Ding, Lijian*; Xu, Peng; Li, Te; Liao, Xiaojian; He, Shan*; Xu, Shihai*,Asperfurandiones A and B, two antifungal furandione analogs from a marine-derived fungus Aspergillus versicolor,Natural Product Research,2019, 33(23): 3404-3408. 20、Li, Jing; Wang, Zhuo; Yang, Fan; Jiao, WeiHua; Lin, HouWen*; Xu, ShiHai*,Two new steroids with cytotoxicity from the marine sponge Dactylospongia elegans collected from the South China Sea,Natural Product Research, 2019, 33(9): 1340-1344. 21、Liang, YongQian; Liao, XiaoJian; Zhao, BingXin*; Xu, ShiHai*,(+ )- and (-)-Spongiterpene, a pair of new valerenane sesquiterpene enantiomers from the marine sponge Spongia Sp.,Natural Product Research, 2019, 16(9): 1-5. 22、Zhang, Hua; Lai,Wei; Guan, ZhuoBin; Liao, XiaoJian; Zhao, BingXin*& Xu, ShiHai*, A new thiodiketopiperzaine from the marine sponge Tedania sp. ,Natural Product Research,2019.2.1-623、Lin,JiaLi; Liang, YongQian; Liao, XiaoJian;Yang,JianTing; Li, Dai-Chun; Huang,YuLing; Jiang, ZhiHui;  Xu, ShiHai*& Zhao, BingXin*, Acanthophoraine A, a new pyrrolidine alkaloid from the red algaAcanthophora spicifera,Natural Product Research,2019,4,1-7,24、Zhou, Rong; Liao, XiaoJian;Li,Hangbin; Li,Jing; Feng,Pengju*; Zhao,Binxin*; Xu, ShiHai*,Isolation and Synthesis of Misszrtine A: A Novel Indole Alkaloid From Marine Sponge-Associated Aspergillus sp. SCSIO XWS03F03,Frontiers in Chemistry, 2018, 6(6): 1-7.25、Zhang, Jun*;Yang, Zhiqiang; Liang, Yan; Zhong, Liping; Lin, Huiting; Zhong, Balian; Li, Liangchun*; Xu,Shihai*; Liu,Yonghong*,Four New C9 Metabolites from the Sponge-Associated Fungus Gliomastix sp ZSDS1-F7-2,Marine Drugs, 2018, 16(7): 0-231.  26、Zhou, Rong;Sun,Yueguang; Li,Hangbin; Long, Weili; Liao, XiaoJian;Feng,Pengju*; Xu, ShiHai*,Synthesis and Biological Evaluation of Reniochalistatins A–E and a Reniochalistatin E Analogue,ChemMedChem, 2018, 13(9): 2202-2207.  27、Li, Jing; Yang, Fan;Wang, ZhuoWei ; Wang,ShuPing; Zhao,BinXin;  Jiao, WeiHua*;Xu, ShiHai*and Lin,HouWen*, Unusual antiinflammatory meroter- penoids from the marine sponge Dactyl ospongia sp.,Org. Biomol. Chem., 2018, 16, 6773 - 6782.28、Hangbin Li,Xiaojian Liao,Yueguang Sun,Rong Zhou,Weili Long,Le Li,Liuqun Gu*and Shihai Xu*,An Economical Synthesis of Caulerpin and Evaluation of Its New Anticancer Activities,ChemistrySelect ,2018, 3, 12406– 12409.29、Li, Jing; Yang, Fan;Liu, Li; Jiao, WeiHua*;Xu, ShiHai*and Lin, HouWen*,Popolohuanones G-I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans,Chem.  Biodiversity , 2018, 15, e1800078,1-730、Wang, Ying; Lin, Xiu Ping; Ju, Zhi Ran; Liao, Xiao Jian; Huang, Xiao Jun; Zhang, Chen; Zhao, Bing Xin*; Xu, Shi Hai*, Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp SCSIO XWS03F03,Journal of Asian Natural Products Research, 2017, 19(7): 684-690.31、Bai, Defa; Yu, Siming; Zhong, Shenghui; Zhao, Bingxin; Qiu, Shaoling; Chen, Jianwei; Lunagariya, Jignesh; Liao, Xiaojian*; Xu, Shihai*,D-Amino Acid Position Influences the Anticancer Activity of Galaxamide Analogs: An Apoptotic Mechanism Study,International Journal of Molecular Sciences, 2017, 18(3): 0-544.  32、Chen, Shengtian; Wang, Junfeng; Wang, Zhen; Lin, Xiuping; Zhao,Bingxin; Kaliaperumal, Kumaravel; Liao, Xiaojian; Tu,Zhengchao; Li, Jianlin; Xu, Shihai*; Liu, Yonghong*,Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation,Fitoterapia, 2017, 117: 71-78.34、Zhang, Jun*; Ip, Fanny C. F.; Liang, Yan; Ip, Nancy Y.; Zhong, BaLian; Lai, ChunWang; Xu, Shihai*,A new iridoid glycoside and a new cinnamoyl glycoside from Scrophularia ningpoensis Hemsl,Natural Product Research, 2017, 31(20): 2361-2368. 35、Zou,Ge; Liao, Xiaojian; Peng,Qi; Chen, GuoDong; Wei,FangYing; Xu, ZhengXiong; Zhao, Bing Xin*and Xu, Shi Hai*, A new α-pyrone from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T),Journal of Asian Natural Products Research, 2017, 15(11),1232-1238.36、 Ju, Zhiran; Qin, Xiaochu; Lin, Xiuping; Wang, Junfeng; Kumaravel Kaliyaperumal; Tian, Yongqi; Liu, Juan ; Liu, Fen; Tu, Zhengchao; Xu, Shi Hai*; Liu, Yonghong*,New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel,Natural Product Research, 2016, 30(2): 192-198. 37、Sun, Huan; Liu, Fen; Feng, Mei-Ran; Peng, Qi; Liao, Xiao-Jian; Liu, Ting-Ting; Zhang, Jun*; Xu, Shi Hai*,Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.,Natural Product Research, 2016, 30(24): 2819-2824. 38、Ding, Lijian; Yuan, Wei; Peng, Qi; Sun, Huan;Xu, Shi Hai*,Secondary Metabolites Isolated from the Sponge-Associated Fungus Nigrospora oryzae,Chemistry of Natural Compounds, 2016, 52(5): 969-970.39、Ding, Lijian; Yuan, Wei; Li, Yingxin; Liao, Xiaojian; Sun, Huan; Peng, Qi; Han, Bingnan; Lin, Houwen; Li, Zhiyong*; Yang, Fan*; Xu, Shi Hai*,Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii,Natural Product Research,2016, 30(14): 1633-1638. 40、Lunagariya, Jignesh; Zhong, Shenghui; Chen, Jianwei; Bai, Defa; Bhadja, Poonam; Long, Weili; Liao, Xiaojian*; Tang, Xiaoli*; Xu, Shi Hai*,Design and Synthesis of Analogues of Marine Natural Product Galaxamide, an N-methylated Cyclic Pentapeptide, as Potential Anti-Tumor Agent in Vitro,Marine Drugs, 2016, 14(9): 0-161. 41、Peng, Qi; Liu, Fen; Sun, Huan; Liao, XiaoJian; Feng, MeiRan; Liu, TingTing; Xu, ZhengXiong; Zhang, Jun*;Xu, Shi Hai*,A new sesquiterpene from the gorgonian coral Menella sp.,Natural Product Research, 2016, 30(20): 2299-2304.  承担课题 主持国家级科研项目:1、国家自然基金面上项目,21672084,海藻中抗污损活性物质研究,2017/01-2020/12,65万元,在研,主持2、国家自然基金面上项目,41876145,海绵中抗海洋污损生物的代谢产物研究,2019/01-2022/12,62万元,在研,主持3、国家自然基金面上项目,41376155,珊瑚中抗污损活性物质研究,2014/01-2017/12,82万元,在研,主持4、国家自然基金面上项目,21172094,南海海绵共附微生物中活性先导化合物发现,2012/01-2015/12,65万元,已结题,主持5、国家自然基金面上项目,20772048,Ircinia属海绵中抗肿瘤活性化合物的发现与优化,2008/01-2010/12,28万元,已结题,主持6、国家自然基金面上项目,20002001,抗肿瘤海洋生物碱研究,2001/01-2003/12,16万元,已结题,主持7、国家“十四五”重点研发项目,2018YFC0310900,深海动植物药物先导化合物高效挖掘与候选药物成药性研究,总经费2367万元,子课题:抗胶质瘤候选药物环五肽GL712的系统成药性评价,2018YFC0310902, 2018,09-2021,09,经费150万元/2367万元,在研,主持;8、国家“十三五”海洋“863”重点研发项目,海洋生物功能天然产物的发掘、优化与合成,远海大型生物全新天然产物的发现与药物先导化合物优化;54万元/1001万元9、科技部863计划,2001AA628100,海藻中抗肿瘤和治疗心血管疾病活性化合物的分离与鉴定,35万元,2002/01-2004/12,已结题,主持10、科技部863计划,20060109Z408,珊瑚中抗肿瘤活性化合物的分离与结构鉴定,80万元,2006/12-2009/11,已结题,主持 发明专利 1、徐石海; 钟生辉; 白德发; 陈建维,一种环五肽合成方法,2016-10-02, 中国, ZL 2016 100239897.2. 2、龙伟立,李杭斌,徐石海*,赵冰心,一种简易高效合成蕨藻红素的方法,2019-09-17,中国, ZL 201810063548.9.3、李杭斌,龙伟立,徐石海*,一种简单合成蕨藻红素的方法,2019-09-17,中国, ZL 201810386674.8.4、周荣,徐石海*,一种活性环八肽Reniochalistatin E及其类似物的合成方法,2019-05-08, 中国,ZL201711057116.9.5、周荣,徐石海*,冯鹏举,廖小建,赵冰心,一种活性生物碱Misszrtlide的合成方法,2019-09-17,中国,ZL 201810057929.6.6、孙月光,李杭斌,徐石海*,一种抗菌活性环六肽Thermoactinoamide A 的合成方法,2020-09-04,中国,ZL201810157377.6.7、周荣,孙月光,徐石海*,廖小建,一类广泛活性环七肽Reniochalistatin A-D的合成方法,2020-12-15,中国,ZL 201810157160.5. 讲授课程 本科:《有机化学》,《有机化学实验》硕士研究生:《天然产物化学》,《有机波谱学》博士研究生:《化学方法导论》一个章节 荣誉奖励 国家级青年人才 社会职务 1、中国家药学会海洋药物专业委员会理事2、中国生物化学与分子生物学会海洋生物化学与分子生物学分会理事 3、广东省化学化工学会有机化学专业委员会理事4、广东省高等学校实验教学指导委员会副主任委员5、广东省实验室安全委员会专家组组长6、《实验室研究与探索》、《实验技术与管理》编委7、国家自然基金通讯评审专家8、广东省、福建省、江西省、河北省、江苏省等科技项目评审专家9、暨南大学分析测试中心主任10、广东海洋协会副会长

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