暨南大学

杨维东

发布日期:2024-04-08 浏览次数:

导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名: 杨维东 部门: 生命科学技术学院 直属机构: 生命科学技术学院 性别: 男 职务: 副院长 职称: 教授 学位: 博士 毕业院校: 中山大学 电子邮箱: tywd@jnu.edu.cn 通讯地址: 广州市黄埔大道西601号暨南大学生命科学技术学院 邮编: 510632 联系方式 通讯地址:广州市黄埔大道西601号 暨南大学生命科学技术学院E-mail: tywd@jnu.edu.cn; jnuywd@163.com 个人简介 暨南大学教授,博士生导师,《生态毒理学报》编委,广东省生理学会副理事长,广东省高等学校生物类教学指导委员会副主任委员。主要从事赤潮毒素对人类健康的危害、环境生物对赤潮毒素的响应与解毒机制、赤潮毒素的生态学意义与生物合成机制等的研究。近年来主持国家重点研发项目(2019YFC1407900)、国家自然科学基金(42076143,41776120,41576116,41176088,40976065)等项目多项,在Chemosphere、Aquat Toxicol、Environ Pollut、Algal Res等期刊发表SCI论文30余篇,获教育部高等学校科学研究优秀成果奖(科学技术)二等奖1项,授权专利6项,广东省教育教学成果一等奖2项、二等奖1项。 学习经历 1989年 本科毕业于西北师范大学化学系1992年 在西北师范大学化学系获得理学硕士学位1999年 在中山大学化学化工学院获得理学博士学位 工作经历 1992-1996 在兰州大学药学院(原兰州医学院药学系)任教1999年 入职暨南大学生命科学技术学院,先后任讲师、副教授(2000)、教授(2006)。 研究方向 1、赤潮毒素与人类健康2、赤潮毒素与水产品安全;3、水生态毒理学 主要论文 [1]Jia-hui Huang, Yu-hu Jiao, Li Li, Da-wei Li, Hong-ye Li, Wei-dong Yang*, 2021. Small RNA analysis of Perna viridis after exposure to Prorocentrum lima, a DSP toxins-producing dinoflagellate. Aquat. Toxicol. 239, 105950. https://doi.org/10.1016/j.aquatox.2021.105950[2]Kuan-Kuan Yuan, Guo-Fang Duan, Qing-Yuan Liu, Hong-Ye Li, Wei-Dong Yang*, 2021. Inhibition of diarrheal shellfish toxins accumulation in the mussel Perna viridis by curcumin and underlying mechanisms. Toxins 13(8), 578. https://doi.org/10.3390/toxins13080578. [3]Yu-hu Jiao, Guang Wang, Da-wei Li, Hong-ye Li, Jie-sheng Liu, Xue-song Yang*, Wei-dong Yang*, 2021. Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos. Mar. Drugs 19, 322. https://doi.org/10.3390/md19060322[4]Hong-Jia Huang, Chu-Qiao Gan, Jia-Hui Huang, Chen Zou, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Variability of Prorocentrum donghaiense response to allelopathic action from Alexandrium pacificum in laboratory culture. J. Oceanol. Limnol. 39(4), 1305-1315.https://doi.org/10.1007/s00343-020-0226-z[5]Xiao-Tong Mao, Rui-Xia Xu, Yu Gao, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy of Alexandrium pacificum on Thalassiosira pseudonana in laboratory cultures. Ecotoxicol. Environ. Saf. 215(1), 112123[6]Jian-Wei Zheng, Xiao-Tong Mao, Mei-Hua Ye, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy and underlying mechanism of Karenia mikimotoi on the diatom Thalassiosira pseudonanaunder laboratory condition. Algal Res. 54, 102229[7]Guo-Fang Duan, Yang Liu, Li-Na Zhang, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Cinnamaldehyde could reduce the accumulation of diarrhetic shellfish toxins in the digestive gland of the mussel Perna viridis under laboratory conditions. Mar. Drugs 19(2), 63.[8]Qian Ye, Jia-hui Huang, Meng Li, Hong-Ye Li, Jie-Sheng Liu, Song-hui Lv*, Wei-dong Yang*, 2020. Responses of cytochrome P450, GST and MXR in the mussel Perna viridis to the exposure of Aureococcus anophagefferens. Mar. Pollut. Bull. 161, 111806[9]Yang Liu, Jian-Wei Zheng, Xi-Chun Peng*, Hong-Ye Li, Lu Huang, Da-Wei Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid. Chemosphere 254, 126874. https://doi.org/10.1016/j.chemosphere.2020.126874[10]Hong-jia Huang, Chu-qiao Gan, Shao-wen Xiao, Cheng Zou, Srinivasan Balamurugan, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2020. Genetic diversity of Prorocentrum donghaiense population during bloom in the East China Sea revealed by microsatellite. J. Appl. Phycol. 32(3), 1851-1862 https://doi.org/10.1007/s10811-020-02113-4[11]Min Dou, Yu-hu Jiao, Jian-Wei Zheng, Gong Zhang*, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. De novo transcriptome analysis of the mussel Perna viridis after exposure to the toxic dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 192, 110265[12]Yu-hu Jiao, Meng Liu, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2019. EMT is the major target for okadaic acid-suppressed the development of neural crest cells in chick embryo. Ecotoxicol. Environ. Saf. 180, 192–201.[13]Zheng-bingHe, Guo-fangDuan, Cai-yingLiang, Hong-yeLi, Jie-shengLiu, Wei-dongYang∗, 2019. Up-regulation of Nrf2-dependent antioxidant defenses inPerna viridisafter exposed toProrocentrum lima. Fish Shellfish Immunol. 90, 173–179. 3.298[14]Xiao-Meng Wei, Mi-Yu Lu, Guo-Fang Duan, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2019. Responses of CYP450 in the mussel Perna viridis after short-term exposure to the DSP toxins-producing dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 176, 178–185.[15]Song Gu, Shao-Wen Xiao, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu and Wei-Dong Yang*, 2019. ABC transporters in Prorocentrum lima and their expression under different environmental conditions including okadaic acid production. Mar. Drugs 17, 259.[16]Jian-wei Zheng, Su-li Liu, Song-Hui Lu*, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018. Proteomic profile in the mussel Perna viridis after short-term exposure to the brown tide alga Aureococcus anophagefferens. Ecotoxicol. Environ. Saf. 162, 365–375[17]Dao-yi Hou, Xiao-tong Mao, Song Gu, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018, Systems-level analysis of metabolic mechanism following nitrogen limitation in benthic dinoflagellate Prorocentrum lima. Algal Res. 33, 389–398.[18]Yu-hu Jiao, Min Dou, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2017. Exposure of okadaic acid alters the angiogenesis in developing chick embryos. Toxicon 133, 74-81.[19]Dao-yi Hou, Jin-jin Liang, Cheng Zou, Hong-ye Li, Jie-sheng Liu*, Wei-dong Yang*, 2016. MRP functional activity and character in the dinoflagellate Prorocentrum lima. J. Appl. Phycol.28(3), 1667–1676.[20]Fei Liu, Zheng-Bing He, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2016. Inhibition of five natural products from Chinese herbs on the growth of Chattonella marina. Environ. Sci. Pollut. Res. 23(17), 17793-17800.[21]Yue Li, Hong-jia Huang, Hongye Li, Jiesheng Liu, Weidong Yang*, 2016. Genetic diversity of Ulva prolifera population in Qingdao coastal water during the green algal blooms revealed by microsatellite. Mar. Pollut. Bull. 111, 237-246.[22]Lu Huang, Su-Li Liu, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015.P-glycoprotein and its inducible expression in three bivalve species after exposure to Prorocentrum lima. Aquat. Toxicol. 169, 123-132. [23]Jin-Jin Liang, Yun-Hui Li, Fei Liu, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Experimental removal of Alexandrium tamarense cells using sulfobetaines and their modified clays. J. Appl. Phycol. 27(6), 2313-2319. [24]Jian Chen, Qian Ye, Hai-Feng Gu, Hong-Ye Li, Song-Hui Lv, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Variability in the allelopathic action of the Alexandrium tamarense species complex along the coast of China. Harmful Algae 47, 17–26. [25]Lin-Xi Dang, Yue Li, Fei Liu, Yong Zhang, Wei-Dong Yang*, Hong-Ye Li,Jie-Sheng Liu, 2015.Chemical response of the toxic dinoflagellate Karenia mikimotoiagainst grazing by three species of zooplankton. J. Eukaryot. Microbiol. 62, 470–480.[26]Lu Huang, Ying Zou, Hui-wen Weng, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins. Environ. Pollut. 196, 350-357.[27]Ying Zou, Xiao-Meng Wei, Hui-Wen Weng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015. Expression profile of eight glutathione S-transferase genes in Crassostrea ariakensis after exposure to DSP toxins producing dinoflagellate Prorocentrum lima. Toxicon 105, 45–55.[28]Lu Huang,Jie Wang,Wen-Chang Chen,Hong-Ye Li,Jie-Sheng Liu*, TaoJiang,Wei-Dong Yang*, 2014. P-glycoprotein expression inPerna viridisafter exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol. 39(2), 254–262. [29]Cheng Zou,Rui-Min Ye,Jian-Wei Zheng,Zhao-He Luo,Hai-Feng Gu,Wei-Dong Yang*,Hong-Ye Li,Jie-Sheng Liu*,2014.Molecular phylogeny and PSP toxin profile of the Alexandrium tamarense species complex along the coast of China.Mar. Pollut. Bull. 89, 209–219. [30]Yan-yan Xu, Jin-Jin Liang, Wei-Dong Yang*, Jie Wang, Hong-Ye Li, Jie-Sheng Liu*, 2014.Cloning and expression analysis of P-glycoprotein gene in Crassostrea ariakensis. Aquaculture 418–419, 39–47. 主要著作 1、杨维东,刘洁生,彭喜春. 微量元素与健康, 武汉: 华中科技大学出版社,20072、齐雨藻等著. 中国南海赤潮研究. 广州: 广东经济出版社, 2008 (撰写:赤潮毒素及其毒理学)3、刘洁生, 朱伟杰, 王子栋. 环境生理学. 北京: 科学出版社, 2011. (参编) 承担课题 1、国家重点研发计划项目:秦皇岛海域生态灾害多发原因及监测预警系统研究(2019YFC1407900),2019.12-2021.12,1649.00万,主持2、国家自然科学基金面上项目:贝类异源物核受体介导贝体中腹泻性贝毒代谢解毒的机制研究(42076143),2021.1-2024.12, 58万(直接经费),主持3、国家自然科学基金面上项目:贝类Nrf2/ARE信号通路参与腹泻性贝毒代谢解毒的分子机制(41776120),2018.1-2021.12, 69万(直接经费),主持4、国家自然科学基金面上项目:双壳贝类细胞色素P450及其在腹泻性贝毒代谢解毒机制中的作用研究(41576116),2016.1-2019.12, 69万(直接经费),主持5、国家自然科学基金面上项目:中国沿海典型产毒甲藻塔玛亚历山大藻的遗传多样性与种源分析(41176088),2012.1-2015.12,69万,主持6、国家自然科学基金面上项目:p-糖蛋白在双壳贝类抗腹泻性贝毒中的作用机制研究(40976065),2010.1-2012.12,44万,主持 发明专利 [1]杨维东,李赟辉,李宏业,刘洁生. 一种甜菜碱衍生物改性粘土及其制备方法和应用. 专利号:201310087281.4;申请日:2015.2.18;授权公告日:2013.7.24;授权公告号:CN103214076A[2]李宏业,刘婉君,陈嘉雯,杨维东,刘洁生. 一种微藻组成型表达启动子及其应用. 专利号:ZL201610269811.0;申请日:2016.4.26;授权公告日:2018.6.15;授权公告号:CN105838715B[3]李宏业,谢伟红,朱聪聪,杨维东,刘洁生. 一种高效克隆及表达的微藻叶绿体载体及其应用. 专利号:ZL201310263325.4;授权公告日:2015.2.18;公开(公告)号: CN103352048B[4]李宏业,朱聪聪,杨维东,刘洁生. 一种海洋微藻叶绿体转化载体及其应用. 专利号:ZL201010285197.X;授权公告日:2012.07.18;公开(公告)号:CN101948871B 讲授课程 动物生理学 社会职务 《生态毒理学报》编委,广东省高等学校生物类教学指导委员会副主任委员,广东省生理学会副理事长。

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