暨南大学

鞠振宇

发布日期:2024-04-08 浏览次数:

导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名: 鞠振宇 部门: 衰老与再生医学研究院 直属机构: 衰老与再生医学研究院 性别: 男 职务: 院长 职称: 研究员 学位: 博士 毕业院校: 德国汉诺威医学院 电子邮箱: zhenyuju@163.com 办公地址: 广东省广州市天河区黄埔大道西601号暨南大学第二理工楼843 通讯地址: 广东省广州市天河区黄埔大道西601号暨南大学第二理工楼843 邮编: 510632 荣誉奖励: 国家杰出青年科学基金获得者,国家级青年人才 联系方式 地址: 广东省广州市天河区黄埔大道西601号暨南大学理工楼8楼843邮编:510632电子邮件:zhenyuju@163.com 个人简介 鞠振宇,研究员,博士生导师,“国华杰出学者”,暨南大学衰老与再生医学研究院院长,再生医学教育部重点实验室主任,国家“杰青”获得者(2015)。毕业于德国汉诺威医学院,获博士学位。现任中国生理协会衰老与健康专业委员会副主任委员,中国细胞生物学学会衰老细胞生物学分会副会长。研究工作聚焦在干细胞衰老的分子机制,及其对组织器官功能和寿命的影响,在Cell、Nat Genet、Nat Med、Cell Stem Cell、Blood等杂志上总计发表SCI论文133篇。获得多个国家级重点或者重大项目,其中包括国家自然科学基金重点项目3项、重大研究计划重点项目1项、重大研究计划集成项目1项、国际合作重点项目1项等。 学习经历 2004/05 - 2007/06德国汉诺威医学院,医学生物学,博士1998/09 - 2001/06中国医科大学,医学,硕士1992/09 - 1997/06山东大学,医学,学士 工作经历 2016/03-至今  特聘教授,院长,暨南大学,衰老与再生医学研究院2011/03 - 2016/02  特聘教授,杭州师范大学医学院衰老研究所2008/07 - 2013/06 组长,中德马普伙伴小组(干细胞衰老研究)2007/08 - 2011/02 特聘教授,实验室主任,中德衰老与再生医学实验室,中国医学科学院医学实验动物研究所2003/08 - 2004/04 访问学者,德国柏林Max Delbrück分子医学中心2001/09 - 2003/07 实习研究员,中国医学科学院阜外心血管病研究所1997/09 - 1998/08 实习医生,山东省东营市胜利油田油建医院 研究方向 器官衰老的分子机制及干预靶点;成体干细胞衰老和组织器官再生;利用动物模型研究如何延缓衰老延长寿命。 主要论文 1.Yi W #, Zhang J #, Huang Y#, Zhan Q, Zou M, Cheng X, Zhang X, Yin Z, Tao S, Cheng H, Wang F, Guo J*, Ju Z*, Chen Z*. Ferritin-Mediated Mitochondrial Iron Homeostasis is essential for the Survival of Hematopoietic Stem Cells and Leukemic Stem Cells. Leukemia. 2024. doi: 10.1038/s41375-024-02169-y. Online ahead of print. (影响因子 11.4)2.Duan W, Ou Z, Huang Y, Zhang Y, Zhang L, Zhao Y, He R, Zhang Y, Ge Y, Lou H*, Ju Z*, Hu Q*. Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries. Antioxidants (Basel). 2023 Dec 15;12(12):2119. (影响因子7.0)3.Aging Biomarker Consortium, Mengmeng Jiang*, et al, Ju Z*, et al, Yunfang Wang*. A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement. Life Medicine. 2024 :lnae004. 4.Aging Biomarker Consortium, Le Zhang*, et al, Ju Z*, et al,,Cuntai Zhang*, A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine .Volume 2, Issue 4, August 2023: lnad033.5.Aging Biomarker Consortium; Bao H*, et al, Ju Z*, et al, Liu GH*. Biomarkers of aging. Sci China Life Sci. 2023 May;66(5):893-1066.(影响因子10.384)6.Liu J#, Zuo H#, Wang Z#, Wang W, Qian X, Xie Y, Peng D, Xie Y, Hong L, You W, Lou H, Luo G, Ren J, Shen B, Zheng J *, Wang H *, Ju Z *. The m6A reader YTHDC1 regulates muscle stem cell proliferation via PI4K-Akt-mTOR signalling. Cell Proliferation. 2023 Feb 1:e13410. (影响因子8. 5)7.Zhang K#, Liu D#, Li Y, Shi Z, Guo J, Gao C, Wang H, Ju Z*, Diao D*. The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia. Haematologica. 2023 Aug 1;108(8):2116-2129. (影响因子 11.4)8.Liu B*#, Zhou YY#, Wu QF, Fu YT, Zhang XL, Wang ZK, Yi WW, Wang H, Chen ZY, Song ZF, Xiong W, Qiu YG, He WF*, and Ju Z*. EVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosis. Cell Death & Dis. 2023, 14(1):71. (影响因子: 9.0)9.Zhang L*, Li Y, Wang Y, Qiu Y, Mou H, Deng Y, Yao J, Xia Z, Zhang W, Zhu D, Qiu Z, Lu Z, Wang J, Yang Z, Mao G, Chen D, Sun L, Liu L*, Ju Z*. mTORC2 Facilitates Liver Regeneration Through Sphingolipid-Induced PPAR-α-Fatty Acid Oxidation. Cell Mol Gastroenterol Hepatol. 2022;14(6):1311-1331.(影响因子 7.2)10.Wu S#, Ge Y#*, Lin K, Liu Q, Zhou H, Hu Q, Zhao Y, He W*, Ju Z*. Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity. Nucleic Acids Res. 2022 Apr 22;50(7):3764-3776. (影响因子 14.9)11.Ma XR, Zhu X, Xiao Y, Gu HM, Zheng SS, Li L, Wang F, Dong ZJ, Wang DX, Wu Y, Yang C, Jiang W, Yao K, Yin Y, Zhang Y, Peng C, Gao L, Meng Z, Hu Z, Liu C, Li L, Chen HZ*, Shu Y*, Ju Z*, Zhao JW*. Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nat Commun. 2022 Mar 9;13(1):1225. (影响因子 16.6)12.Pan Y#, Zuo H#, Wen F, Huang F, Zhu Y, Cao L, Sha QQ, Li Y, Zhang H, Shi M, Liang C, Huang J, Zou L, Fan HY, Ju Z*, Wang H*, Shen L*. HMCES safeguards genome integrity and long-term self-renewal of hematopoietic stem cells during stress responses. Leukemia. 2022 Apr;36(4):1123-1131. (影响因子11.4)13.Zhu X#, Chen Z#, Shen W, Huang G, Sedivy JM, Wang H*, Ju Z*. Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention. Signal Transduct Target Ther. 2021 Jun 28;6(1):245. (影响因子39.3)14.Zhou Y, Wang Z, Huang Y, Bai C, Zhang X, Fang M, Ju Z*, Liu B*. Membrane dynamics of ATG4B and LC3 in autophagosome formation. J Mol Cell Biol. 2022 Jan 29;13(12):853-863. (影响因子 5.5)15.Hu Q*, Zhang Y, Lou H, Ou Z, Liu J, Duan W, Wang H, Ge Y, Min J, Wang F*, Ju Z*(co-corresponding). GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis. Cell Death Dis. 2021 Jul 15;12(7):706. (影响因子 9.0)16.He W, Wang X, Ni Y, Li Z, Liu W, Chang Z, Li H, Ju Z*(co-corresponding), Li Z*. Wip1 regulates hematopoietic stem cell development in the mouse embryo. Haematologica. 2021 Feb 1;106(2):580-584. (影响因子 10.1)17.Shi Z, Diao D*, Zhao Y, Luo Y, Li Y, Liu D, Zhang K, Qiu Y, Song Z, Ju Z*(co-corresponding). C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing TF3/ROS-induced cell apoptosis. Aging Cell. 2021 Jun 15; e13382. doi: 10.1111/acel.13382. (影响因子 7.8) 18.Le R*, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, Li Z, Guo M, Kou X, Zhao Y, Zhao A, Chen M, Zhu Q, Yin J, Sun J, Su Z, Shi K, Gao Y, Chen J, Kang L, Wang Y, Li C, Wang H, Ju Z*(co-corresponding), Gao S*. Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells. Cell Stem Cell. 2021 Apr 1;28(4):732-747.e9. (影响因子 23.9)19.Yi W, Zhang Y, Liu Bo*, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Yao, Qiu Y, Huang G, Chen Z*, Chen C*, Ju Z*(co-corresponding). Protein S-nitrosylation Regulates Proteostasis and Viability of Hematopoietic Stem Cell during Regeneration. Cell Rep. 2021 Mar 30;34(13):108922. (影响因子 8.8) 20.Zhang L, Qiu Y, Yang F, Yao J, Wang Y, Qin Y, Mou H, Jing Q*, Liu L*, Ju Z* (co-corresponding). Hepatic microRNA-126 Deficiency Restrains Liver Regeneration Through p53 Pathway In Mice. Signal Transduction and Targeted Therapy. 2021 Jan 28;6(1):32. doi: 10.1038/s41392-020-00395-1. (影响因子 39.3)21.Wang Y*, Zheng JP, Luo Y, Wang J, Xu L, Wang J, Sedivy JM, Song Z*, Wang H*, Ju Z*(co-corresponding). L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia. Signal Transduction and Targeted Therapy. 2020 Sep 19;5(1):205. (影响因子 39.3)22.Han B, Jiang W, Liu H, Wang J, Zheng K, Cui P, Feng Y, Dang C, Bu Y, Wang QM, Ju Z*(co-corresponding), Hao J*. Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Theranostics. 2020 Feb 3;10(6):2832-2848. (影响因子12.4)23.Zhu X*, Shen W, Yao K, Wang H, Liu B, Li T, Song L, Diao D, Mao G, Huang P, Li C, Zhang H, Zou Y, Qiu Y, Zhao Y, Wang W, Yang Y, Hu Z, Auwerx J, Loscalzo J, Zhou Y*, Ju Z*(co-corresponding). Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity. Circulation Research. 2019 Sep 13;125(7):707-719.  (影响因子 20.1)24.Wang X, Gao Y, Gao J, Li M, Zhou M, Wang J, Pang Y, Cheng H, Yuan C, Chu Y, Jiang Y, Zhou J, Luo HR, Ju Z*(co-corresponding), Cheng T*, Yuan W*. Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo. Haematologica. 2019 Feb;104(2):245-255. (影响因子 11.047)25.Yang F, Huang Y, Chen X, Liu L, Liao D, Zhang H, Huang G, Liu W, Zhu X, Wang W, Lobo CA, Yazdanbakhsh K, An X, Ju Z*.  Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis. Haematologica. 2019 Feb 28; 104(10):1984-1994. (影响因子 11.047)26.Wang H*, Zuo H, Liu J, Wen F, Gao Y, Zhu X, Liu B, Xiao F, Wang W, Huang G, Shen B*, Ju Z*(co-corresponding). Loss of YTHDF2 mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration. Cell Res. 2018 Oct;28(10):1035-1038. (影响因子 46.297) 27.Diao D*, Wang H, Li T, Shi Z, Jin X, Sperka T, Zhu X, Zhang M, Yang F, Cong Y, Shen L, Zhan Q, Yan J, Song Z, Ju Z*. Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan. EMBO Rep. 2018 Oct;19(10). pii: e45494. (影响因子 9.071)28.Tang H, Wang H, Cheng X, Fan X, Yang F, Zhang M,Chen Y, Tian Y, Liu C, Shao D,  Jiang B, Dou Y, Cong Y, Xing J, Zhang X, Yi X, Songyang Z, Ma W, Zhao Y, Wang X, Ma J, Myriam Gorospe, Ju Z* (co-corresponding), Wang W*. HuR regulates telomerase activity through TERC methylation. Nat Commun 2018 Jun 7;9(1):2213. (影响因子 17.694)29.Kang Y, Zhang H, Zhao Y, Wang Y, Wang W, He Y, Zhang W, Zhang W, Zhu X, Zhou Y, Zhang L, Ju Z*(co-corresponding), Shi L*. Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis. Cell Rep. 2018 Mar 27;22(13):3493-3506. (影响因子 9.995)30.Zhang C, Yi W, Li F, Du X, Wang H, Wu P, Peng C, Luo M, Hua W, Wong CC, Lee JJ, Li W, Chen Z, Ying S*, Ju Z*(co-corresponding), Shen H*. Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis. Cell Res. 2018 Mar; 28(3):323-335. (影响因子 46.297)31.Zhu X, Shen W, Wang Y, Jaiswal A, Ju Z*(co-corresponding), Sheng Q*. Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice. Signal Transduction and Targeted Therapy .2017 Jul 7;2: 17017. (影响因子 38.104)32.Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, Chen H, Wang M, Ju Z*(co-corresponding), Cong Y*. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1a stability. Nat Commun 2017 Jan 27;8:14186. (影响因子 17.694)33.Wang H*, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL,Liu G, LiT, JuZ*(co-corresponding). SIRT6 Controls Hematopoietic Stem Cell Homeostasis through the Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016 Apr 7;18(4):495-507. (影响因子 25.269)   34.Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y*, Ju Z*(co-corresponding). Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8. (影响因子 25.476) 35.Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z*(corresponding). Wip1-deficiency Impairs Hematopoietic Stem Cell Function via p53 and mTORC1 Pathways. Nature Commun. 2015 Apr 16;6:6808. doi: 10.1038/ncomms7808. (影响因子 17.694)36.Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z*(corresponding). Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR. Hepatology. 2015 Jun;61(6):2030-41. (影响因子17.298)37.ChenY ,Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W,Rudolph KL,Zhan Q, Ju Z*(corresponding). Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice. Blood. 2014 Feb 6;123(6):851-62. (影响因子 25.476) 38.Chen Y, Yang R, Guo P, Ju Z*(corresponding). Gadd45a Deletion Aggravates Hematopoietic Stem Cell Dysfunction in ATM-deficient Mice. Protein Cell. 2014 Jan 29 ;5(1):80-9. (影响因子 15.328)39.Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z*(co-corresponding), Gao S*. Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells. Cell Stem Cell. 2014 Jan 2;14(1):27-39. (影响因子 25.269)   40.Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, Wang Y, Sun H, Chen X, Xu C, Li S, Pang Y, Zhang G, Yang L, Zhu L, Fan M, Shang A, Ju Z, Luo L, Ding Y, Guo W,Yuan W, Yang X, Liu B. Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell. 2012 Nov 2;11(5):663-75. (影响因子 25.269)   41.Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012 Mar 2;148(5):1001-14. (影响因子 66.85)42.Song Z, Zhang J, Ju Z*(co-corresponding), Rudolph KL*. Telomere dysfunctional environment induces loss of quiescence and Inherent impairments of hematopoietic stem cell function. Aging Cell. 2012 Jun;11(3):449-55. (影响因子 9.304)43.Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR,Rudolph KL. Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol. 2011 Dec 4;14(1):73-9. (影响因子 28.213)44.Xiao F, Zheng X, Cui M, Shi G, Chen X, Li R, Song Z, Rudolph KL, Chen B*, Ju Z*(co-corresponding). Telomere dysfunction-related serological markers are associated with type 2 diabetes. Diabetes Care. 2011 Oct;34(10):2273-8. (影响因子 17.152)45.Song Z, Wang J, Guachalla LM, Terszowski G, Rodewald HR, Ju Z*(co-corresponding), Rudolph KL*. Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood. 2010 Feb 25; 115(8):1481-9. (影响因子25.476)46.Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C, Eisner GM, Jose PA, Rudolph KL, Ju Z*(corresponding). Short Telomeres and Prognosis of Hypertension in a Chinese Population. Hypertension. 2009 Apr;53(4):639-45. (影响因子 9.897)47.Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell .2007 Sep 7;130(5):863-77. (影响因子 66.85)48.Ju Z, Hong J, Jaworski M, Gompf A, Rathinam C, Klein C, Trumpp A, Rudolph KL. Telomere dysfunction induces environmental defects limiting hematopoietic stem cell function and engraftment. Nature Medicine. 2007 Jun;13(6):742-7. (影响因子 87.241)49.Choudhury AR, Ju Z(co-first), Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nature Genetics. 2007 Jan, 39(1):99-105. (影响因子 41.307) 主要著作 1、著作名称:《Advances in Stem Cell Aging》中第四章“Hematopoietic Stem Cell Aging and Cancer”。作者:Chen Y, Ju Z. 出版社:Karger. 出版时间:2012年。ISBN 978-3-318-02170-72、著作名称:《衰老、痴呆与预防医学新进展》中第八章“成体干细胞衰老的研究进展”。作者:张俊伶、鞠振宇。出版社:科学技术文献出版社。出版时间:2013年6月。ISBN 978-7-5023-8024-33、著作名称:《基础血液学》。编委:鞠振宇。出版社:科学出版社。出版时间:2019年6月。ISBN 978-7-03-061180-24、著作名称:《疾病学基础》。编委:鞠振宇。出版社:人民卫生出版社。出版时间:2021年11月。ISBN 978-7-117-31569-25、著作名称:《Ferroptosis》中“Assessment of Ferroptosis in Hematopoietic Stem and Progenitor Cells”部分。作者: Zhang, Y., Chen, Z., Ju, Z, Hu, Q。出版社:Humana。出版时间:2023年8月。 承担课题 1、广东省普通高校创新团队项目“衰老的能量代谢与表观遗传研究创新团队”(项目编号2023KCXTD004),2024.01-2026.12 50万。(排名1/6)2、国家自然科学基金重点项目“染色质高级结构及多组学技术协同解析造血干细胞衰老的表观遗传机制研究 ”( 批准号82230047),2023.01-2027.12,263万。(排名1/9)3、国家重点研发计划(干细胞研究与器官修复专项)“解析成体干细胞在稳态、应激、衰老中命运和功能的表观调控机制”,(批准号2021YFA1100103),2021.12-2026.06,757.5万。(排名1/6)4、国家自然科学基金重大研究计划集成项目“集成新型代谢探针和多组学技术系统解析器官衰老的深层机制”(批准号92049304) 2021.01-2024.12,400万。(排名1/10)5、国家自然科学基金重点项目“蛋白质稳态失衡响应机制及其在器官衰老中的作用 ”(批准号82030039),2021.01-2025.12,297万。(排名1/10)6、国家自然科学基金国家重大研究计划重点支持项目“细胞能量代谢与炎症反应在端粒-线粒体稳态维持和器官衰老中的作用及机制”(批准号:91749203),2018.01-2021.12,200万。(排名1/10)7、国家重点研发计划(干细胞及转化研究专项)“造血干细胞衰老的表观遗传机制”,(批准号2017YFA0103302),2017.07-2021.12,750万。(排名1/18)8、国家自然科学基金国家杰出青年科学基金项目“老年医学”(批准号81525010),2016-2020,400万。(排名1/1)9、国家自然科学基金重点国际(地区)合作研究项目“SIRT6和ALT介导的端粒维持机制在干细胞衰老与疾病中的作用”(批准号81420108017), 2015-2019,320万。(排名1/10)10、国家自然科学基金重点项目“端粒、p53和mTOR信号分子在骨髓衰竭性疾病中的作用”(批准号81130074),2012-2016,260万。(排名1/10)11、国家自然科学基金优秀青年科学基金项目“老年医学”(批准号81222003),2013-2015,100万。(排名1/1)12、浙江省自然科学基金杰出青年项目“端粒和 PGC1α 信号通路在造血干细胞衰老和人类疾病中的作用”(批准号LR13H250001), 2013-2016,37万(排名1/1)13、国家重点研发计划(干细胞及转化研究专项)“HSC稳态维持的调节机制”(批准号2016YFA0100602)研究骨干,2016-2020,本实验室获494万。(排名2)14、国家重点基础研究发展计划(973计划)“端粒相关蛋白及其在人类重大疾病中的作用”中课题3“端粒相关蛋白在细胞衰老中的作用机制”(批准号2012CB911203)研究骨干,2012-2016,702万。(排名3/7)本实验室获213万。15、国家重点基础研究发展计划(973计划)“造血干细胞维持、衰老与再生的调控机制研究”中课题2“造血干细胞衰老的关键分子及调控机制”(批准号2011CB964802)课题负责人,2011-2015,533万。(排名1/15)16、国家自然科学基金面上项目“端粒缩短对肺干细胞衰老和肺间质纤维化的影响”(批准号81070047),2011-2013,39万,结题。(排名1/7)17、国家自然科学基金面上项目“端粒功能损伤引起细胞外环境衰老的分子机制”(批准号30771189),2008/01-2010/12,30万,结题,主持.18、德国马普学会Max Plank Society基金 “Molecular Mechanisms of Stem Cell Aging”,2008-2013,10万欧元。19、英国Methuselah Foundation “Stem Cell Transplantation for Slowing the Process of Aging”,2009-2014,20万欧元。 发明专利 1、Wip1抑制剂在制备治疗肝再生不足疾病药物中的应用,中国,专利号ZL201510006803.2,申请日期2015.01.07,授权日期2017.07.28,鞠振宇、张玲玲和刘雷明。2、Wnt抑制剂在制备治疗造血再生障碍性疾病药物中的应用,中国,专利号ZL201610183285.6,申请日期2016.03.28,授权日期2018.11.13,鞠振宇、汪虎。3、何首乌提取物的制备方法及其制剂和应用,中国,专利号ZL201610371380.9,申请日期2016.05.30, 授权日期2021.08.10,王伽伯、鞠振宇、肖小河、郜丹、易微微。 荣誉奖励 国家杰出青年科学基金获得者,国家级青年人才 社会职务 中国生理协会衰老与健康专业委员会副主任委员细胞生物学学会衰老细胞生物学分会副会长中国老年保健医学研究会老年健康科技创新分会常务委员中国病理生理学会生物活性小分子专业委员会常务委员中国老年学和老年医学学会老年病学分会衰老基础医学专业委员会常务委员中国老年学和老年医学学会抗衰老分会常务委员中国老年医学学会基础与转化医学分会常务委员中国营养学会精准营养产业分会副主任委员

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