张文宇

综合介绍 General Introduction PI简介：张文宇，西北工业大学教授，博导。2010年6月毕业于苏州大学生物信息学专业，获理学学士学位。2010年9月至2015年底为苏州大学和美国芝加哥大学联合培养博士，研究方向为系统生物学和演化遗传学。2016年底至2022年夏在德国马克斯-普朗克演化生物学研究所进行博士后训练，主要从事动物群体基因组学方向的研究工作。2022年9月入职西北工业大学生态环境学院，担任动物进化与生态基因组学课题组组长。张文宇博士长期从事动物适应性进化和复杂性状遗传创新机制的研究。前期主要以小家鼠、果蝇等动物为研究系统，通过采用系统生物学、进化遗传学、分子生物学实验等多学科交叉策略，重点研究了动物适应进化过程中新起源基因的演化模式以及重要性状的遗传机制。主要学术贡献有：1）首次实验证实了复杂数量性状的“全基因遗传模型”(omnigenic model)，为GWAS研究中“消失的遗传率”这一现象的出现提供了新的见解，更新了 领域内通常使用基因编辑实验对GWAS关联基因进行验证的合理性的认知(Current Biology 2021; Molecular Ecology 2020)；2）阐明了逆转座起源新基因在物种内微进化过程的功能演化模式，证实了尽管小部分的逆转座新基因 拷贝有可能在短时间内快速获得适应性进化功能(Mol. Biol. Evol. 2022)，但大多数新近产生的逆转座基因拷贝对个体存在有害影响，进而受到强烈的负向自然选择作用被快速从群体中清除(PNAS 2021)；3）阐明了新起源基因的网络演化模式和功能演化机制，揭示了新基因从网络边缘逐步进入网络 内部，并演变为高度连接中枢基因的网络演化过程，并发现一些新基因在整合到原有基因网络的过程中获得了重要的生物学功能(Genome Biology 2015; Sci. China Life Sci. 2019)。 个人相册

教育教学

教育教学 Education and teaching 招生信息 欢迎对进化生物学、计算生物学、基因组学和动物生态学（尤其是节肢动物或昆虫方向）感兴趣的博士后、研究生和本科生加入团队。详情请直接与课题组组长联系: wyzhang@nwpu.edu.cn

荣誉获奖

获奖信息 The winning information 2023年入选国家优青（海外）项目2023年入选德国马普学会伙伴研究组组长2023年入选陕西省青年科技新星2022年获得美国国家遗传学会DeLill Nasser专业发展奖2022年入选西北工业大学翱翔海外学者2016年入选苏州大学优秀博士毕业论文

科学研究

社会兼职 Social Appointments 期刊评审：Genome Biology, Molecular Biology and Evolution (MBE), Molecular Ecology(ME), Molecular Ecology Resources(MER), Bioinformatics, Briefings in Bioinformatics, Protein & Cell, Science China Life Sciences, Journal of Systematics and Evolution.

学术成果

学术成果 Academic Achievements 五篇代表性论文（#通讯作者）Wenyu Zhang(#) and Diethard Tautz. Tracing the origin and evolutionary fate of recent gene retrocopies in natural populations of the house mouse. Mol. Biol. Evol. 2022 Feb 3;39(2):msab360. doi: 10.1093/molbev/msab360. [Link]Wenyu Zhang, Chen Xie, Kristian Ullrich, Yong E. Zhang and Diethard Tautz(#). The mutational load in natural populations is significantly affected by high primary rates of retroposition. PNAS. 2021 Feb 9;118(6):e2013043118. doi: 10.1073/pnas.2013043118. (Media reports) [Link]Wenyu Zhang, Guy Reeves, and Diethard Tautz(#). Testing implications of the omnigenic model for the genetic analysis of loci identified through genome-wide association. Current Biology. 2021 Mar 08;31(5):1092-1098.e6. doi: 10.1016/j.cub.2020.12.023. (Dispatch report) [Link]Wenyu Zhang, Guy Reeves, and Diethard Tautz(#). Identification of a genetic network for an ecologically relevant behavioral phenotype in Drosophila melanogaster. Mol Ecol. 2020 Feb;29(3):502-518. doi: 10.1111/mec.15341. [Link]Wenyu Zhang, Patrick Landback, Andrea R Gschwend, Bairong Shen(#), and Manyuan Long(#). New genes drive the evolution of gene interaction networks in the human and mouse genomes. Genome Biol. 2015 Oct 1;16:202. doi: 10.1186/s13059-015-0772-4. (Recommended by F1000 Faculty) [Link]完整发表文章列表（#通讯作者；*共同一作）>>> Year 2023Wei Zhang(#), Li Zhang and Wenyu Zhang. Editorial: The origination of genetic novelties: New genes, new regulations, and new cell types. Front. Genet. 2023 13:1118926. doi: 10.3389/fgene.2022.1118926. [Link]>>> Year 2022Wenyu Zhang(#) and Diethard Tautz. Tracing the origin and evolutionary fate of recent gene retrocopies in natural populations of the house mouse. Mol Biol Evol. 2022 Feb 3;39(2):msab360. doi: 10.1093/molbev/msab360. [Link]>>> Year 2021Wenyu Zhang, Chen Xie, Kristian Ullrich, Yong E. Zhang and Diethard Tautz(#). The mutational load in natural populations is significantly affected by high primary rates of retroposition. PNAS. 2021 Feb 9;118(6):e2013043118. doi: 10.1073/pnas.2013043118. (Media reports) [Link]Wenyu Zhang, Guy Reeves, and Diethard Tautz(#). Testing implications of the omnigenic model for the genetic analysis of loci identified through genome-wide association. Current Biology. 2021 Mar 08;31(5):1092-1098.e6. doi: 10.1016/j.cub.2020.12.023. (Dispatch report) [Link]>>> Year 2020Wenyu Zhang, Guy Reeves, and Diethard Tautz(#). Identification of a genetic network for an ecologically relevant behavioral phenotype in Drosophila melanogaster. Mol Ecol. 2020 Feb;29(3):502-518. doi: 10.1111/mec.15341. [Link]Chen Xie(#), Cemalettin Bekpen, Sven Künzel, Maryam Keshavarz, Rebecca Krebs-Wheaton, Neva Skrabar, Kristian K Ullrich, Wenyu Zhang, Diethard Tautz. Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines. PLoS Comput Biol. 2020 Nov 12;16(11):e1008354. doi: 10.1371/journal.pcbi.1008354. [Link]>>> Year 2019 and beforeWenyu Zhang, Yuanxiao Gao, Manyuan Long, and Bairong Shen(#). Origination and evolution of orphan genes and de novo genes in the genome of Caenorhabditis elegans. Sci China Life Sci. 2019 Apr;62(4): 579-593. doi: 10.1007/s11427-019-9482-0. [Link]Jian Zu(#), Yuexi Gu, Yu Li, Chentong Li, Wenyu Zhang, Yong E. Zhang, UnJin Lee, Li Zhang, and Manyuan Long(#). Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors. Sci China Life Sci. 2019 Apr;62(4):594-608. doi: 10.1007/s11427-019-9483-6. [Link]Wenyu Zhang, Patrick Landback, Andrea R Gschwend, Bairong Shen(#), and Manyuan Long(#). New genes drive the evolution of gene interaction networks in the human and mouse genomes. Genome Biol. 2015 Oct 1;16:202. doi: 10.1186/s13059-015-0772-4. (Recommended by F1000 Faculty) [Link]Jin Zhu(*), Sugui Wang(*), Wenyu Zhang(*), Junyi Qiu, Yuxi Shan, Dongrong Yang(#), and Bairong Shen(#). Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network. Oncotarget. 2015 Dec 22; 6(41):43819-30. doi: 10.18632 /oncotarget. 6102. [Link]Wenying Yan, Lihua Xu, Zhandong Sun, Yuxin Lin, Wenyu Zhang, Jiajia Chen, Shaoyan Hu, and Bairong Shen(#). MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model. Oncotarget. 2015 Sep 22;6(28):26424-36. doi: 10.18632/oncotarget.4459. [Link]Wenyu Zhang(*), Jin Zang(*), Xinhua Jing, Zhandong Sun, Wenying Yan, Dongrong Yang, Feng Guo(#), and Bairong Shen(#). Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer. J Transl Med. 2014 Mar 11;12:66. doi: 10.1186/1479-5876-12-66. [Link]Wenying Yan, Maomin Sun, Guang Hu, Jianhong Zhou, Wenyu Zhang, Jiajia Chen, Biao Chen, and Bairong Shen(#). Amino acid contact energy networks impact protein structure and evolution. J Theor Biol. 2014 Aug 21;355:95-104. doi: 10.1016/ j.jtbi. 2014.03.032. [Link]Jing Shang, Fei Zhu, Wanwipa Vongsangnak, Yifei Tang, Wenyu Zhang, and Bairong Shen(#). Evaluation and comparison of multiple aligners for next-generation sequencing data analysis. Biomed Res Int. 2014:309650. doi: 10.1155/2014/309650. [Link]Jiajia Chen, Daqing Zhang, Wenyu Zhang, Yifei Tang, Wenying Yan, Lingchuan Guo, and Bairong Shen(#). Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis. J Transl Med. 2013 Jul 10;11:169. doi: 10.1186/1479-5876-11-169. [Link]Wenyu Zhang, Jiajia Chen, Yang Yang, Yifei Tang, Jing Shang, and Bairong Shen(#). A practical comparison of de novo genome assembly software tools for next-generation sequencing technologies. PLoS One. 2011 Mar 14;6(3):e17915. doi: 10.1371/ journal.pone.0017915. [Link]Li- Ping Gan, Wen-Yu Zhang, Yan-Shan Niu, Li Xu, Jian Xi, Ming-Ming Ji, and Shi-Qing Xu(#). Construction and application of an electronic spatio-temporal expression profile and gene ontology analysis platform based on the EST database of the silkworm, Bombyx mori. J Insect Sci. 2010;10:114. doi: 10.1673/031.010.11401. [Link]

综合介绍