燕云峰

个人简介  燕云峰，博士。2007年从中国科学技术大学化学物理系博士毕业。2011年3月至2017年1月，先后在美国麻省大学和德克萨斯大学西南医学中心做博士后和研究员。主要研究方向是生物材料与纳米生物药物，包括针对核酸药物（siRNA，mRNA，gRNA等）的新型高分子和脂质载体的研究开发及其在癌症治疗、组织工程和免疫调控等方面应用。主持浙江省和国家自然科学基金多项，目前担任中国感光学会生物基功能大分子材料与技术专业委员会委员、中国毒理学会青年委员会委员、浙江省毒理学会毒理学替代法专业委员会委员。长期担任Nat. Commun., J. Mater. Chem. B, Chem. Commun., Acs Appl. Mater. Inter. Sci., Acta Biomater.等主流期刊审稿人。办公室：莫干山校区生工楼A523。联系方式：0571-88813129; 13588095990; yfyan@zjut.edu.cn 教学与课程 主讲/共同主讲本科生《细胞生物学》、《纳米生物学》、《专业英语》和研究生《科技论文写作》等课程。 育人成果 科研项目 1、国家自然科学基金/面上项目，含二硒键信使RNA脂质载体的构建和性能研究，2023.1-2026.122、国家自然科学基金/联合基金，高分子-siRNA纳米粒子的内部结构及其对siRNA递送的影响，2020.1-2022.123、浙江省自然科学基金/一般项目，PAGE-b-PEO-b-PCL功能化嵌段共聚物的制备及其在信使 RNA递送中的应用，2019.1-2021.124、横向项目，类脂质体的合成技术开发，2021.6-2023.125、聚合物分子工程国家重点实验室开放课题基金。2017-2019 科研成果 52. Qi Shuai, Wanxuan Xie, Siyuan Chen, Huahui Su and Yunfeng Yan* Novel aromatic moieties-modified poly(glycidyl amine)s with potent siRNA delivery and cancer treatment effect Journal of Materials Chemistry B, 2024, 12, 311551. Qidi Ren, Lu Wang, Wenfei Qian, Baiqiu Chen, Qi Shuai,* and Yunfeng Yan* Flash Nanoprecipitation Fabrication of PEI@Amorphous Calcium Carbonate Hybrid Nanoparticles for siRNA Delivery Macromolecular Bioscience, 2023, 23, 2300085 50. Yunfeng Yan,* Xiaomin Liu, Longyu Wang, Chengfan Wu, Qi Shuai, Yanmei Zhang, and Shuai Liu Branched Hydrophobic Tails in Lipid Nanoparticles Enhance mRNA Delivery for Cancer Immunotherapy Biomaterials, 2023, 301, 12227949. Yunfeng Yan, Fangtao Zhu, Huahui Su, Xiaomin Liu, Qidi Ren, Fangqian Huang, Wenbo Ye, Mengdan Zhao, Yunchun Zhao, Junpeng Zhao*, and Qi Shuai* Construction of Degradable and Amphiphilic Triblock Polymer Carriers for Effective Delivery of siRNA Macromolecular Bioscience, 2022, 22, 220023248. Yunfeng Yan*, Guangliang Zhang, Chengfan Wu, Qidi Ren, Xiaomin Liu, Fangqian Huang, Yi Cao, and Wenbo Ye Structural Exploration of Polycationic Nanoparticles for siRNA Delivery ACS Biomaterials Science & Engineering, 2022, 8, 1964-197447. Wenbo Ye, Fangtao Zhu, Yue Cai, Longyu Wang, Guangliang Zhang, Guangkuo Zhao, Xiaohe Chu, Qi Shuai, Yunfeng Yan* Improved paclitaxel delivery with PEG-b-PLA/zein nanoparticles prepared via flash nanoprecipitation International Journal of Biological Macromolecules, 2022, 221, 486-49546. Wenbo Ye, Guangliang Zhang, Xiaomin Liu, Qidi Ren, Fangqian Huang, Yunfeng Yan* Fabrication of polysaccharide-stabilized zein nanoparticles by flash nanoprecipitation for doxorubicin sustained release Journal of Drug Delivery Science and Technology, 2022, 70, 10318345. Wen Zhang, Wenbo Ye, Yajun Wang, Yunfeng Yan* Microfluidic fabrication of tunable alginate-based microfibers for the stable immobilization of enzymes Biotechnology Journal, 2022, 17, 220009844. Wen Zhang, Wenbo Ye, Yunfeng Yan* Advances in Photo‐Crosslinkable Materials for 3D Bioprinting Advanced Engineering Materials, 2022, 24, 210066343. Fengfan Liu, Huahui Su, Mengqian Li, Wanxuan Xie, Yunfeng Yan*, Qi Shuai* Zwitterionic Modification of Polyethyleneimine for Efficient In Vitro siRNA Delivery International Journal of Molecular Sciences, 2022, 23, 501442. Qi Shuai, Fangtao Zhu, Mengdan Zhao, YunfengYan* mRNA delivery via non-viral carriers for biomedical applications International Journal of Pharmaceutics, 2021, 607, 12102041. Lu Wang, Yunfeng Yan* A Review of pH-Responsive Organic-Inorganic Hybrid Nanoparticles for RNAi-Based Therapeutics Macromolecular Bioscience, 2021, 21, e210018340. Guangkuo Zhao, Tongtong Ge, Yunfeng Yan, Qi Shuai*, Weike Su Highly Efficient Modular Construction of Functional Drug Delivery Platform Based on Amphiphilic Biodegradable Polymers via Click Chemistry International Journal of Molecular Sciences, 2021, 22, 10407 39. Xianjing Jia, Yunfeng Yan, A Basak Kayitmazer, Yongsheng Li*, Yisheng Xu* Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics Advanced Functional Materials, 2021, 31, 210045238. Chengyuan Xu, Yang Chen, Yi Si*, Yunfeng Yan, Basak Kayitmazer, Yong Ding, Weiwei Qian, Zhiyuan Zheng, Song Cao, Yisheng Xu* Injectable and Biocompatible Mussel‐Inspired Adhesive for Enhanced Reendothelialization of Injured Artery Advanced Materials Interfaces, 2021, 8, 200195537. Yi Hou*, Xiaolin Wei*, Yunfeng Yan*, Jing Hao* Target-Triggered Nanoparticles for Tumor Diagnosis and Therapy Frontiers in Chemistry, 2021, 9, 65778236. Lian Xue, Yunfeng Yan, * Petra Kos, Xiaoping Chen, Daniel J. Siegwart* PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery Drug Delivery and Translational Research, 2021, 11, 255–26035. Kejin Zhou, Lindsay T. Johnson, Hu Xiong, Sergio Barrios, Jonathan T. Minnig, Yunfeng Yan, Bethanie Abram, Xueliang Yu, and Daniel J. Siegwart* Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles Molecular Pharmaceutics, 2020, 17, 1575-158534. Yunfeng Yan* and Hangwei Ding pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review Nanomaterials, 2020, 10, 161333. Xiaohan Wang, Xiaotao Zhao, Kai Zheng, Xuhong Guo, Yunfeng Yan,* and Yisheng Xu* Ratiometric nanoparticle array-based near infrared fluorescent probes for quantitative protein sensing Langmuir, 2019, 15, 5599-5607 32. Chengyuan Xu#, Yunfeng Yan#, Jinchao Tan, Dahai Yang, Xianjing Jia, Lu Wang, Yisheng Xu,* Song Cao,* and Shengtong Sun* Biodegradable Nanoparticles of Polyacrylic Acid Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition Advanced Functional Materials, 2019, 29, 1801846 （共同一作）31. Hu Xiong, Kejin Zhou, Yunfeng Yan, Jason B. Miller, and Daniel J. Siegwart Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy Acs Applied Materials & Interfaces, 2018, 10, 16335–16343 30. Meng Li, Yisheng Xu*, Jinli Sun, Mingwei Wang, Dahai Yang, Xuhong Guo, Haiyun Song, Song Cao*, and Yunfeng Yan* Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation Acs Applied Materials & Interfaces, 2018, 10, 10752-1076029. Yunfeng Yan*, Hu Xiong, Xinyi Zhang, Qiang Chen, and Daniel J. Siegwart* Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers Biomacromolecules, 2017, 18, 4307-431528. Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, and Daniel J. Siegwart High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes Advanced Materials, 2017, 29, 170013127. Yunfeng Yan, Kejin Zhou, Hu Xiong, Jason B. Miller, Edward A. Motea, David A. Boothman, Li Liu, and Daniel J. Siegwart Aerosol Delivery of Stabilized Polyester-siRNA Nanoparticles to Silence Gene Expression in Orthotopic Lung Tumors Biomaterials, 2017, 118, 84-9326. Yunfeng Yan, Li Liu, Hu Xiong, Jason B. Miller, Kejin Zhou, Petra Kos, Kenneth E. Huffman, Sussana Elkassih, John W. Norman, Ryan Carstens, James Kim, John D. Minna, and Daniel J. Siegwart Functional Polyesters Enable Selective siRNA Delivery to Lung Cancer over Matched Normal Cells Proceedings of the National Academy of Sciences of the United States of America, 2016, 113, E5702-E571025. Kejin Zhou, Liem H. Nguyen, Jason B Miller, Yunfeng Yan, Petra Kos, Lin Li, Jing Hao, Jonathan T Minnig, Hu Xiong, Hao Zhu, and Daniel J Siegwart Modular Degradable Dendrimers Enable Small RNAs to Extend Survival in an Aggressive Liver Cancer Model Proceedings of the National Academy of Sciences of the United States of America, 2016, 113, 520-52524. Kejin Zhou, Petra Kos, Yunfeng Yan, Hu Xiong, Yi-Li Min, Karina A. Kinghorn, Jonathan T. Minnig, Jason B. Miller, and  Daniel J. Siegwart Intercalation-mediated Nucleic Acid Nanoparticles for siRNA Delivery Chemical Communications, 2016, 52, 12155-1215823. Hu Xiong, Petra Kos, Yunfeng Yan, Kejin Zhou, Jason B. Miller, Sussana Elkassih, and Daniel J. Siegwart Activatable Water Soluble Probes Enhance Tumor Imaging by Responding to Dysregulated pH and Exhibiting High Tumor-to-liver Fluorescence Emission Contrast Bioconjugate Chemistry, 2016, 27, 1737-174422. Jing Hao, Petra Kos, Kejin Zhou, Jason B Miller, Lian Xue, Yunfeng Yan, Hu Xiong, Sussana Elkassih, Daniel J Siegwart Rapid Synthesis of a Lipocationic Polyester Library via Ring-opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery Journal of the American Chemical Society, 2015, 137, 9206–920921.Yunfeng Yan, Lian Xue, Jason B Miller, Kejin Zhou, Petra Kos, Sussana Elkassih, Li Liu, Atsushi Nagai, Hu Xiong, Daniel J Siegwart One-pot Synthesis of Functional Poly(aminoester sulfide)s and Utility in Delivering pDNA and siRNA Polymer, 2015, 72, 271-28020. Ebru Kizilay, Daniel Seeman, Yunfeng Yan, Xiaosong Du, Paul L. Dubin, Laurence Donato-Capel, Lionel Bovetto and Christophe Schmitt Structure of Bovine β-Lactoglobulin/Lactoferrin Coacervates Soft Matter, 2014, 10, 7262-726819. Yunfeng Yan and Daniel Siegwart Scalable Synthesis and Derivation of Functional Polyesters Bearing Ene and Epoxide Side Chains Polymer Chemistry, 2014, 5, 1362-137118. Yunfeng Yan, Ebru Kizilay, Daniel Seeman, Sean Flanagan, Paul L. Dubin, Lionel Bovetto, Laurence Donato and Christophe Schmitt Heteroprotein Complex Coacervation: Bovine β-Lactoglobulin and Lactoferrin Langmuir, 2013, 29, 15614-1562317. Yisheng Xu, Yoni Engel, Yunfeng Yan, Kaimin Chen, Daniel F. Moyano, Paul L. Dubin, Vincent M. Rotello Enhanced Electrostatic Discrimination of Proteins on Nanoparticle-coated Surfaces Journal of Materials Chemistry B, 2013, 1, 5230-523416. Yunfeng Yan, Daniel Seeman, Bingqian Zheng, Ebru Kizilay, Yisheng Xu, and Paul L. Dubin pH-Dependent Aggregation and Disaggregation of Native β-Lactoglobulin in Low Salt Langmuir, 2013, 29, 4584-459315. Yunfeng Yan, Hongwei Hou, Tianrui Ren, Yisheng Xu,Quanxi Wang, and Wenping Xu Utilization of Environmental Waste Cyanobacteria as a Pesticide Carrier: Studies on Controlled release and photostability of Avermectin Colloids and Surfaces B, 2013, 102, 341-34714. Yunfeng Yan, Jingjing Liu, Yubing Xiong, Ye Cheng and Ping Yao Superoxide Dismutase Binding and Release Behaviors of Dodecylated Poly(allylamine)s: Effects of Self-aggregation and Organic Solvents Macromolecular Chemistry and Physics, 2012, 213, 1540-154913. Yisheng Xu, Daniel Seeman, Yunfeng Yan, Lianhong Sun, Jared Post, and Paul L. Dubin Effect of Heparin on Protein Aggregation: Inhibition versus Promotion Biomacromolecules, 2012, 13, 1642-165112. Yisheng Xu, Yunfeng Yan, Daniel Seeman, Lianhong Sun, and Paul L. Dubin Multimerization and Aggregation of Native-State Insulin: Effect of Zinc Langmuir, 2012, 28, 579-58611. Jingjing Liu, Yunfeng Yan, and Ping Yao Binding of Thermo-sensitive and pH-sensitive Butylated Poly(allylamine)s with Lysozyme Chinese Journal of Polymer Science, 2011, 29, 397-40610. Hongwei Hou, Tianrui Ren, Yunfeng Yan, Quanxi Wang, Wenping Xu Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property The Chinese Journal of Process Engineering, 2011, 5, 0249. Yakun Wu, Tianrui Ren, Yunfeng Yan, Qinghai Wu, Quanxi Wang, Wenping Xu Preparation and Controlled Release Properties of Emamectin Benzoate with Microcystis as Carrier The Chinese Journal of Process Engineering, 2011, 3, 0208. Gao Gao, Yunfeng Yan, Stergios Pispas, Ping Yao Sustained and Extended Release with Structural and Activity Recovery of Lysozyme from Complexes with Sodium (Sulfamate-Carboxylate)Isoprene/Ethylene Oxide Block Copolymer Macromolecular Bioscience, 2010, 10, 139-1467. Yubing Xiong, Hong Wang, Rongmin Wang, Yunfeng Yan, Bo Zheng, Yunpu Wang A Facile One-step Synthesis to Cross-linked Polymeric Nanoparticles as Highly Active and Selective Catalysts for Cycloaddition of CO2 to Epoxides Chemical Communications, 2010, 46, 3399-34016. Lidong Wang, Tianrui Ren, Yunfeng Yan, Songrui Yu, Wenping Xu Synthesis and Characterization of Carboxylate Sulfonate Copolymer Dispersant The Chinese Journal of Process Engineering, 2010, 6, 0285. Lijuan Ai, Tianrui Ren, Yunfeng Yan Application of Environmental Waste Cyanobacteria as a Carrier for the Controlled Release of Tebuconazole World Pesticides,2010, 6, 013.4. Yunfeng Yan, Jinhua Hu, Ping Yao Effects of Casein, Ovalbumin and Dextran on the Astringency of Tea Polyphenols Determined by Quartz Crystal Microbalance with Dissipation Langmuir, 2009, 25, 397-4023. Yunfeng Yan, Guangming Liu, Yecang Tang, Guangzhao Zhang In situ Investigation on Layer-by-Layer Deposition of Polyelectrolytes by Quartz Crystal Microbalance Chinese Journal of Chemical Physics, 2008, 21, 291-2942. Yunfeng Yan, Xuechang Zhou, Jing Ji, Lifeng Yan, Guangzhao Zhang Adsorption of Polymeric Micelles and Vesicles on a Surface Journal of Physical Chemistry B, 2006, 110, 21055-210591. Li Liang, Ping Yao, Ming Jiang, Guangzhao Zhang, Yunfeng Yan Interactions of Apo Cytochrome c with Alternating Copolymers of Maleic Acid and Alkene Langmuir, 2005, 21, 10662-10670 社会服务