杨凡

杨凡 22 个人信息Personal Information 中级 教师英文名称：Fan Yang 教师拼音名称：Yang Fan 出生日期：1991-09-07 电子邮箱： fan@yzu.edu.cn 入职时间：2021-04-19 所在单位：医学院 学历：全日制学术型博士 办公地点：扬州市江阳中路136号6号楼218 性别：男 联系方式：fan@yzu.edu.cn 学位：全日制学术学位博士 在职信息：在岗 毕业院校：南京医科大学 学科：人体解剖与组织胚胎学 其他联系方式Other Contact Information 邮编 : 225000 通讯/办公地址 : 扬州市江阳中路136号扬州大学医学院19号楼501 办公室电话 : 0514-87978878 邮箱 : fan@yzu.edu.cn 个人简介Personal Profile 基础医学系组织胚胎学教研室教师。博士毕业于南京医科大学生殖医学与子代健康全国重点实验室。2018年至2020年在美国宾夕法尼亚大学兽医学院生物医学系学习，师从“Father of Transgenesis”、美国国家科学奖获得者、美国三院院士Ralph Brinster教授。 The research in Dr. Yang’s laboratory focuses on the biology of the spermatogonial stem cell (SSC), which is responsible for the continuity of spermatogenesis in the adult male. A spermatogonial transplantation technique has been developed that provides a functional assay of stem cell activity, thereby enabling for the first time an analysis of this unique and valuable stem cell population. Using the transplantation assay the surface antigenic profile of the SSC has been established for several species, and this information allows highly enriched populations of stem cells to be obtained. These enriched SSCs from mouse and rat can now be cultured, and their number increased for long periods. Techniques to extend the culture system to farm animals and primates are under investigation. Additionally, genes are being introduced into the SSC as a technique to modify the germline of animals. Development of culture and gene modification methods for rodent SSCs will lay the foundation for similar approaches in larger animals, particularly farm animals. The culture and enrichment strategies also are being used to study gene activity in stem cells and differentiating daughter cells arising from the stem cells. Using similar methods, signaling pathways active in the fate decision determining stem cell self-renewal or differentiation are under investigation. Since the SSC is the only adult stem cell for which there exists a long-term in vitro culture system and a quantitative functional transplantation assay, it provides a powerful model to understand stem cell function in all adult stem cell systems. In addition, the SSC is the only stem cell in the adult that continually replicates and transmits genes to the next generation. Perhaps most important, it is the vehicle for species continuity and evolutionary adaptation. 教育经历Education Background 工作经历Work Experience 2018.4 2020.7 宾夕法尼亚大学 生殖生理学 2010.9 2014.6 南京中医药大学 中药学 医学学士学位 2014.9 2017.6 南京中医药大学 中药学 医学硕士学位 2017.9 2020.12 南京医科大学 生殖医学 医学博士学位 2021.4 至今 扬州大学 医学院 讲师 在岗 研究方向Research Focus 社会兼职Social Affiliations 生殖干细胞发育 精原干细胞 再生医学 2022.7 至今 江苏省解剖学会会员