聂桓

基本信息 科学研究 教学研究 新建主栏目 基本信息 名称 教授/博导,中国细胞生物学会理事、中国生化与分子生物学教委会青年委员。 一直从事癌症糖生物学和代谢组学的基础研究工作。作为黑龙江省优秀研究生团队和哈工大创新团队的成员，在国内首次掌握并改进了高通量N-糖基化分析的关键技术，从血清、体外培养细胞和组织多个层面研究癌症特异改变的糖链分子和小分子代谢物，已经完成上千例的样品分析工作，并深入探讨其发生改变的分子机制。 科研方面，主持国家自然基金4项，中国博士后基金、教育部留学归国人员科研启动基因、深研院合作项目及省博士后启动基金等多项目。 担任国家自然基金项目一审匿名评审专家。已发表SCI论文40余篇，在Journalof Proteomics发表的论文作为杂志季度Top 25 hottest articles. 研究领域 名称 主要从事糖生物学和代谢生物学的研究工作 1. Zhang X, Dou P, Akhtar ML, Liu F, Hu X, Yang L, Yang D, Zhang X, Li Y, Qiao S, Li K, Tang R, Zhan C, Ma Y, Cheng Q, Bai Y, Han F, Nie H*, Li Y*. NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44. Oncogene. 2021 Jul 19. (SCI IF：9.867） 2. Yang D, Yang L, Cai J, Hu X, Li H, Zhang X, Zhang X, Chen X, Dong H, Nie H*, Li Y.* A sweet spot for macrophages: Focusing on polarization. Pharmacological research, 2021, 167: 105576（SCI IF：7.658） 3. Wenyang Zhou, Chang Xu, Pingping Wang, Meng Luo, Zhaochun Xu, Rui Cheng, Xiyun Jin, Yu Guo, Guangfu Xue, Liran Juan, Anastasia A Anashkina, Huan Nie*, Qinghua Jiang*. N439K Variant in Spike Protein Alter the Infection Efficiency and Antigenicity of SARS-CoV-2 Based on Molecular Dynamics Simulation. Front Cell Dev Biol. 2021 Aug 3;9:697035. (SCI IF: 6.684) 4. Pingping Wang, Xiyun Jin, Wenyang Zhou, Meng Luo, Zhaochun Xu, Chang Xu, Yiqun Li, Kexin Ma, Huimin Cao, Yan Huang, Guangfu Xue, Shuilin Jin, Huan Nie*, Qinghua Jiang*. Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing. Genomics. 2021 Mar;113(2):456-462. (SCI IF: 5.736) 5. Wenyang Zhou, Fan Yang, Zhaochun Xu, Meng Luo, Pingping Wang, Yu Guo, Huan Nie*, Lifen Yao*, Qinghua Jiang*. Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing. Front Genet. 2020 Jan 23;10:1379. (SCI IF: 4.599) 6. Lixing Xiao, Guoying Zou, Rui Cheng, Pingping Wang, Kexin Ma, Huimin Cao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Yan Huang, Xiaoyu Lin, Huan Nie*, Qinghua Jiang*. Alternative splicing associated with cancer stemness in kidney renal clear cellcarcinoma. BMC Cancer. 2021 Jun 15;21(1):703. (SCI IF: 4.43) 7. Pingping Wang, Lifen Yao, Meng Luo, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Shi Yan, Yiqun Li, Chang Xu, Rui Cheng, Yan Huang, Xiaoyu Lin, Kexin Ma, Huimin Cao, Hongxin Liu, Guangfu Xue, Fang Han, Huan Nie, Qinghua Jiang. Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson's disease. Cell Discovery. 2021 Jul 20;7(1):52. 8. Zhaochun Xu, Meng Luo, Weizhong Lin, Guangfu Xue, Pingping Wang, Xiyun Jin, Chang Xu, Wenyang Zhou, Yideng Cai, Wenyi Yang, Huan Nie, Qinghua Jiang. DLpTCR: an ensemble deep learning framework for predicting immunogenic peptide recognized by T cell receptor. Briefings in Bioinformatics. 2021. (Accepted) 9. Xiyun Jin, Wenyang Zhou, Meng Luo, Pingping Wang, Zhaochun Xu, Kexin Ma, Huimin Cao, Chang Xu, Yan Huang, Rui Cheng, Lixing Xiao, Xiaoyu Lin, Fenglan Pang, Yiqun Li, Huan Nie, Qinghua Jiang. Global characterization of B cell receptor repertoire across COVID-19 patients by single-cell V(D)J sequencing. Briefings in Bioinformatics. 2021 May 20:bbab192. 10. Pingping Wang, Lifen Yao, Meng Luo, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Shi Yan, Yiqun Li, Chang Xu, Rui Cheng, Yan Huang, Xiaoyu Lin, Kexin Ma, Huimin Cao, Hongxin Liu, Guangfu Xue, Fang Han, Huan Nie, Qinghua Jiang. Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson's disease. Cell Discovery. 2021 Jul 20;7(1):52. 11. Ma S, Zhang F, Zhou F, Li H, Ge W, Gan R, Nie H, Li B, Wang Y, Wu M, Li D, Wang D, Wang Z, You Y, Huang Z. Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19. Signal Transduct Target Ther. 2021 May 13;6(1):191. 12. Zhang X, Shi X, Lu X, Li Y, Zhan C, Akhtar ML, Yang L, Bai Y, Zhao J, Wang Y, Yao Y, Li Y, Nie H*. Novel Metabolomics Serum Biomarkers for Pancreatic Ductal Adenocarcinoma by the Comparison of Pre-, Postoperative and Normal Samples. J Cancer. 2020 May 19;11(16):4641-4651. （SCI IF：4.20） 13. Wang C, Yang D, Zhang X, Zhang X, Yang L, Wang P, Zhou W, Li H, Li Y, Nie H*, Li Y*.Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy [J]. Frontiers in genetics, 2020, 11: 298. （SCI IF：4.599） 14. Zhang X, Nie H, Whited J, Wang D, Li Y, Sun X L. Recent approaches for directly profiling cell surface sialoform. Glycobiology, 2018, 28(12): 910-24. （指导学生一作）(SCI IF：4.313） 15. Dou P, Li Y, Sun H, Xie W, Zhang X, Zhang X, Zhang D, Qiao S, Ci Y, Nie H, Han F, Li Y. C1orf109L binding DHX9 promotes DNA damage depended on the R-loop accumulation and enhances camptothecin chemosensitivity. Cell Prolif. 2020 Sep;53(9):e12875. 16. Zhang H, Chen J, Wang H, Lu X, Li K, Yang C, Wu F, Xu Z, Nie H, Ding B, Guo Z, Li Y, Wang J, Li Y, Dai Z. Serum Metabolomics Associating With Circulating MicroRNA Profiles Reveal the Role of miR-383-5p in Rat Hippocampus Under Simulated Microgravity. Front Physiol. 2020 Aug 18;11:939. 17. Lu X, Zhang X, Zhang Y, Zhang K, Zhan C, Shi X, Li Y, Zhao J, Bai Y, Wang Y, Nie H*, Li Y*. Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2. Mol Carcinog. 2019 May;58(5):749-759. (SCI IF：4.784） 18. Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, Yao Y, Dou P, Akhtar ML, Nie H, He J, Li Y. MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. Mol Carcinog. 2019 Aug;58(8):1410-1426 19. Whited J, Zhang X, Nie H, Wang D, Li Y, Sun X L. Recent Chemical Biology Approaches for Profiling Cell Surface Sialylation Status. ACS chemical biology, 2018, 13(9): 2364-74. 20. Vabbilisetty P, Boron M, Nie H, Ozhegov E, Sun XL. Chemical Reactive Anchoring Lipids with Different Performance for Cell Surface Re-engineering Application. ACS Omega. 2018 Feb 28;3(2):1589-1599. 21. Wang C#, Nie H#, Li Y#, Liu G, Wang X, Xing S, Zhang L, Chen X, Chen Y, Li Y. The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy andchemotherapy of NSCLC. Sci Rep. 2016 Jun 1;6:26526. (SCI IF：4.379） 22. Wang D, Ozhegov E, Wang L, Zhou A, Nie H, Li Y, Sun XL. Sialylation and desialylation dynamics of monocytes upon differentiation and polarization to macrophages. Glycoconj J. 2016 Oct;33(5):725-33. 23. Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, Wenjuan Huo, Anshun He, Yuanfei Yao, Yu Jin, Youpeng Qu, Xue-Long Sun, Yu Li. Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyl transferases-IVa Regulation. Sci Rep. 2015; 5: 16007. (SCI IF：4.379） 24. Xin Lu, Huan Nie, Yiqun Li, Chao Zhan, Xia Liu, Xiuyun Shi,Ming Shi, Yubao Zhang,Yu Li. Comprehensive Characterization and Evaluation of Hepatocellular Carcinoma by LC-MS Based Serum. Metabolomics, 2015, 11(5):1381-1393（指导学生一作） (SCI IF: 4.290) 25. Narla SN, Nie H, Li Y, Sun XL. Multi-dimensional glycan microarrays with glyco-macroligands. Glycoconj J. 2015 Oct;32(7):483-95.（指导学生一作） (SCI IF: 2.916) 26. Wang D, Nie H, Ozhegov E, Wang L, Zhou A, Li Y, Sun XL. Globally profiling sialylation status of macrophages upon statin treatment. Glycobiology. 2015 Sep;25(9):1007-15.（指导学生一作） (SCI IF: 4.313) 27. Huan Nie, Xin Lu, Yiqun Li, Xiuyun Shi, Kun Zhang, Yu Li.Comprehensive characterization and evaluation of hepatocellular carcinoma by LC–MS based metabolomics.2015 The 1st Asia-Pacific Joint Symposium on Life Sciences, POSTECH 28. Narla SN, Pinnamaneni P, Nie H, Li Y ,Sun XL, BSA-boronic acid conjugate as lectin mimetics. Biochem Biophys Res Commun.2014; J443(2):562-7. 29. Xia Liu, Huan Nie, Yubao Zhang, Yuanfei Yao, Alaiyi Maitikabili, Youpeng Qu, Shuliang Shi, Cuiying Chen, and Yu Li, Cell Surface-Specific N-Glycan Profiling in Breast Cancer, Plos One, 2013; 8 (8): e72704. （指导学生一作） (SCI IF: 3.240) 30. Shi M, Wang S, Yao Y, Li Y, Zhang H, Han F, Nie H, Su J, Wang Z, Yue L, Cao J, Li Y. Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer. Sci Rep. 2014 Dec 18;4:7545. 31. Xu S, Wu H, Nie H, Yue L, Jiang H, Xiao S, Li Y.AIF downregulation and its interaction with STK3 in renal cell carcinoma. PLoS One. 2014 Jul 3;9(7):e100824. 32. Nie Huan, Yao Yuanfei, Ding Ning, Liu Xia, Qu Youpeng, Li Yu.The N-Glycomic research on the Serum Biomarkers of Breast Cancer. Clinical and Experimental Pharmacoogy and Physiology. 2013; （40）, Issue Supplement s1, 16 (SCI IF: 2.557) 33. Xia Liu, Huan Nie, Xuelong Sun, Yu Li，The Study on the Alteration Mechanism of Specific N-glycan for Hepatocellular Carcinoma. 9th Annual Midwest Carbohydrate and Glycobiology Symposium.2013,10, America, Toledo,23, 34. Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in Sialic Acid-Focused Glycomics. Journal of Proteomics. 2012; 75(11):3098-3112, (SCI IF: 4.044) 35. Ding N, Nie H, Sun X, Sun W, Qu Y, Liu X, Yao Y, Liang X, Chen CC, Li Y. Human Serum N-Glycan Profiles Are Age and Sex Dependent. Age Ageing. 2011; 40(5):568-75. （指导学生一作） (SCI IF: 10.668) 36. Satya Nandana Narla, Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in the Synthesis and Biomedical Applications of Chain-End Functionalized Glycopolymers. Journal of Carbohydrate Chemistry, 2012; 31(2):67-92, (SCI IF: 1.667) 37. Huan Nie, Xia Liu, Ying Han, Tingting Li, Youpeng Qu, Yu Li. Alteration of Cell Surface-Specific N-glycan for Hepatocellular Carcinoma by DSA-FACE. 2012 the Chinese Biochemistry and Molecular Biology, 2012.08. Cheng Du 38. Youtao Yu, Yubao Zhang, Jianran Hu, Hao Zhang , Shan Wang, Fang Han, Lei Yue, Youpeng Qu, Yao Zhang, Hongjian Liang, Huan Nie, Yu Li. MARVELD1 inhibited cell proliferation and enhance chemosensitivity via increasing expression of p53 and p16 in hepatocellular carcinoma. Cancer Science. 2012;103(4):716-22. 3.896 39. Huan Nie, Ding ning,Sun wei,Yu Youtao ,Yu Yan,Zhang Yubao ,Qu Youpeng, Wang Shan, Li Yu. N-Glycomic Changes in Serum for the Discovery of Potential Biomarkers of Breast Cancer. 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, Shang Hai, 2009 40. Li R, Tian YY, Gao Y, Wang S, Nie H, Li Y. Silencing LRP1B with huge transcript by RNAi method. [Article in Chinese]Yi Chuan. 2009 Jan;31(1):36-42. 41. Peng J, Yang L, Yang F, Yang J, Yan Y, Nie H, Zhang X, Xiong Z, Jiang Y, Cheng F, Xu X, Chen S, Sun L, Li W, Shen Y, Shao Z, Liang X, Xu J, Jin Q. Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics. 2008; 91(1):78-87. 42. Yang J#, Nie H#, Chen L, Zhang X, Yang F, Xu X, Zhu Y, Yu J, Jin Q. Revisiting the Molecular Evolutionary History of Shigella spp. J Mol Evol. 2007; 64(1):71-9 (SCI IF: 2.395) 43. Nie H, Yang F, Zhang X, Yang J, Chen L, Wang J, Xiong Z, Peng J, Sun L, Dong J, Xue Y, Xu X, Chen S, Yao Z, Shen Y, Jin Q. Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics. 2006; 7:173. (SCI IF: 3.969) 44. Xiong Z, Tang X, Yang F, Zhang X, Yang J, Chen L, Nie H, Yan Y, Jiang Y, Wang J, Xue Y, Xu X, Zhu Y, Dong J, An L, Wang X, Jin Q.Comparison of the virulence plasmid genomes of two strains of Shigella which lost the ability to bind Congo red.Sci China C Life Sci. 2006; 49(2):141-8. 45. Liu W, Nie H, Wang S, et al.. Mapping a resistance gene in wheat cultivar Yangfu 9311 to yellow mosaic virus, using microsatellite markers. Theor Appl Genet. 2005; 111(4):651-7. （导师一作） (SCI IF: 5.699) 46. Wei-Hua LIU, Huan NIE, Zhen-Tian HE, Xiu-Lan CHEN, et al..Mapping of a Wheat Resistance Gene to Yellow Mosaic Disease by Amplified Fragment Length Polymorphism and Simple Sequence Repeat Markers. Journal of Integrative Plant Biology 2005; 47 (9): 1133（导师一作）(SCI IF: 7.061) 47. Yang F, Yang J, Zhang X, Chen L, Jiang Y, Yan Y, Tang X, Wang J, Xiong Z, Dong J, Xue Y, Zhu Y, Xu X, Sun L, Chen S, Nie H, Peng J, Xu J, Wang Y, Yuan Z, Wen Y, Yao Z, Shen Y, Qiang B, Hou Y, Yu J, Jin Q. Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res. 2005; 33(19):6445-58. 48. Jiang Y, Yang F, Zhang X, Yang J, Chen L, Yan Y, Nie H, Xiong Z, Wang J, Dong J, Xue Y, Xu X, Zhu Y, Chen S, Jin Q.The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid. 2005; 54(2):149-59. 讲授课程 名称 教学方面，主讲4门课程，其中研究生学位科1门“生物大分子结构与功能”，本科生必修课1门“生物化学”, 全校选修课1门“生命的化学”，全英文实验课1门“生物化学基础实验”。 教学效果优秀。连续多年A+ 曾获校“青年教师教学基本功竞赛” 二等奖，校“研究生课程青年教师教学竞赛”二等奖。主编著作1部，已完成研究生课程教材讲义1部，参编“十二五”规划教材1部。 荣获黑龙江省高校师德先进个人、哈尔滨工业大学立德树人先进导师、校优秀工会工作者等荣誉。 招生信息 名称 每年1-2名硕士生，1名博士生