马秋月

基本信息 论文/项目 新建主栏目 基本信息 名称 马秋月，博士，哈尔滨工业大学医学与健康学院副教授，河南省高层次人才。2019年12月毕业于德国慕尼黑大学医学院，获得人类生物学博士学位（导师为Hans-Joachim Anders教授）。随后在慕尼黑大学医学院肾内科实验室、慕尼黑工业大学临床化学与病理生物化学学院Jurgen Ruland教授（德国科学院院士、2021莱布尼茨奖获得者）实验室从事博士后研究员的工作。2022年10月加入哈尔滨工业大学医学与健康学院。主要研究方向为免疫调节、纳米材料与疾病诊疗。近年来，在Blood, Nat. Rev. Nephrol, J. Am. Soc. Nephrol, J. Immunol等高水平SCI期刊发表多篇论文。 研究领域 名称 研究方向： 1，免疫微环境调控机制（炎症损伤、肿瘤）及相关纳米药物研发； 2，mRNA纳米递送系统及其在CAR-T细胞治疗中的应用研究； 3，纳米生物效应 4，细胞通讯网络调控 招生信息 名称 硕士招生2-3名每年： 欢迎化学材料、生物医学、生物信息学等方向同学加入！ 本科生课题： 每年2-3人，欢迎做毕业设计的本科生及其他年级本科生通过邮件申请。 实验室特点： 工作环境友好、科研氛围轻松，注重提高效率，培养自主学习能力和科研能力。 开展国内外广泛合作，可以为在读期间科研能力优秀的同学提供国际合作、访学以及海外高校深造推荐等机会。 实验室地址：科学园科创大厦1618，欢迎大家来访交流。 友情链接 链接名称 刘绍琴 教授研究组 链接地址 http://homepage.hit.edu.cn/shaoqinliu 简单介绍 期刊论文 名称 1. Ma Q, Immler R, Pruenster M, Sellmayr M, Li C, von Brunn A, von Brunn B, Ehmann RK, Wolfel R, Napoli M, Li Q, Romagnani P, Bottcher RT, Sperandio M, Anders HJ, Steiger S. Soluble uric acid inhibits β2-integrin-mediated neutrophil recruitment in innate immunity. Blood. 2022 Mar 18. (封面文章，及专家点评) 2. Ma Q, Grigorescu M, Schreiber A, Kettritz R, Lindenmeyer M, Anders HJ, Steiger S. Genetic background but not intestinal microbiota determines hyperoxaluria-related nephrocalcinosis in common inbred mouse strains. Front Immunol. 2021 Apr 21;12:673423. 3. Ma Q, Mohsen H, Chenyu L, Markus S, Maja L, Markus S, Claudia B, Romagnani P, Anders HJ, Steiger S. Soluble Uric Acid Is an Intrinsic Negative Regulator of Monocyte Activation in Monosodium Urate Crystal–Induced Tissue Inflammation. J Immunol. 2020 Aug 1;205(3):789-800. 4. Steiger S, Ma Q, Anders HJ. The case for evidence-based-medicine for the association between hyperuricemia and CKD. Nat Rev Nephrol. 2020; Jul;16(7):422. 5. Sellmayr M, Hernandez M, Ma Q, Krüger N, Liapis H, Brink A, Lenz B, Angelotti ML, Gnemmi V, Kuppe C, Kim H, Tajti F, Saez-Rodriguez J, Lech M, Kramann R, Romagnani P, Anders HJ, Steiger S. Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease. J Am Soc Nephrol. 2020 Dec;31(12):2773-2792. 6. Steiger S*, Grill JF*, Ma Q*, Bauerle T, Jordan J, Smolle M, Bohland C, Lech M, Anders HJ. Biological drugs elicit a dual effect on calcium oxalate crystallization and progressive nephrocalcinosis-related chronic kidney disease. Front Immunol. 2018 Mar 29;9:619. 7. Ma Q, Steiger S, Anders HJ. Sodium glucose transporter-2 inhibition has no renoprotective effects on non-diabetic chronic kidney disease. Physiol Rep. 2017 Apr;5(7): e13228. 8. Gnemmi V, Li Q, Ma Q, De Chiara L, Carangelo G, Li C, Molina-Van den Bosch M, Romagnani P, Anders HJ, Steiger S. Asymptomatic hyperuricemia promotes recovery from ischemic organ injury by modulating the phenotype of macrophages. Cells. 2022 Feb 11;11(4). 9. Kim T, Lautenschlager S, Ma Q, Eller K, Pollheimer MJ, Lazarin-Bidóia D, Nakamura CV, Anders HJ, Steiger S. Drug Crystal-Related Gastrointestinal Complications Involve Crystal-Induced Release of Neutrophil and Monocyte Extracellular Traps. Cells. 2020 Nov 15;9(11):2481. 10. Ma Q, Sun C, Yang F, Wang L, Qin W, Xia X, Feng X, Du C, Gu J, Han W, Lei L. Macrophages largely contribute to heterologous anti-Propionibacterium acnes antibody-mediated protection from Actinobacillus pleuropneumoniae infection in mice. Microbiol Immunol. 2015 Mar;59(3):166-73. 11. Yang F*, Ma Q*, Lei L, Huang J, Ji Q, Zhai R, Wang L, Wang Y, Li L, Sun C, Feng X, Han W. Specific humoral immune response induced by propionibacterium acnes can prevent Actinobacillus pleuropneumoniae infection in mice. Clin Vaccine Immunol. 2014 Mar;21(3):407-16. 12. Liu JF, Ma QY, Zhu RN, Cheng MJ, Bao CT, Gu JM, Sun CJ, Langford PR, Han WY, Lei LC. An anti-Propionibacterium acnes antibody shows heterologous resistance to an Actinobacillus pleuropneumoniae infection independent of neutrophils in mice. Immunol Res. 2017 Dec;65(6):1124-1129. 13. Liu J, Ma Q, Yang F, Zhu R, Gu J, Sun C, Feng X, Du C, Langford PR, Han W, Yang J, Lei L. B cell cross-epitope of Propionibacterium acnes and Actinobacillus pleuropneumonia selected by phage display library can efficiently protect from Actinobacillus pleuropneumonia infection. Vet Microbiol. 2017 Jun;205:14-21. 14. Qin W, Wang L, Zhai R, Ma Q, Liu J, Bao C, Sun D, Zhang H, Sun C, Feng X, Gu J, Du C, Han W, Langford PR, Lei L. Apa2H1, the first head domain of Apa2 trimeric autotransporter adhesin, activates mouse bone marrow-derived dendritic cells and immunization with Apa2H1 protects against Actinobacillus pleuropneumoniae infection. Mol Immunol. 2017 Jan;81:108-117. 15. Qin W, Wang L, Zhai R, Ma Q, Liu J, Bao C, Zhang H, Sun C, Feng X, Gu J, Du C, Han W, Langford PR, Lei L. Trimeric autotransporter adhesins contribute to Actinobacillus pleuropneumoniae pathogenicity in mice and regulate bacterial gene expression during interactions between bacteria and porcine primary alveolar macrophages. Antonie Van Leeuwenhoek. 2016 Jan;109(1):51-70. 会议摘要/报告 名称 1. Qiuyue Ma, Viviane Gnemmi, Anders Hans-Joachim, Stefanie Steiger. Asymptomatic hyperuricemia acts as antioxidant during acute kidney injury and disease. Nephrology Dialysis Transplantation. Volume 36, Issue Supplement_1, May 2021, gfab084.001. 2. Qiuyue Ma, Roland Immler, Monika Prünster, Paola Romagnani, Markus Sperandio, Hans-Joachim Anders, Stefanie Steiger. Asymptomatic hyperuricemia, a regulator of innate immunity in chronic kidney disease. Nephrology Dialysis Transplantation. Volume 35, Issue Supplement_3, June 2020, gfaa139.SO079. 3. Q Ma, M Sellmayr, F Preitner, HJ Anders, S Steiger. Why do not all chronic kidney disease patients get gout? impaired neutrophil chemotaxis in hyperuricemia-related CKD. Annals of the Rheumatic Diseases. June 2018. 77(Suppl 2):224.3-225. （会议报告） 4. Qiuyue Ma. Hyperuricemia inhibits β2 integrin-mediated neutrophil migration in acute gouty arthritis during renal failure. European Crystal Network workshop. March 2019 in Paris, France. (会议报告，获得一等奖1/1，并作为特邀嘉宾参加2020年会议) 5. Qiuyue Ma. Leukocyte infiltration is impaired in MSU crystal-induced inflammation in a mouse model of hyperuricemic nephropathy. Development of Tissue- and Pathogen-specific Cellular Innate Immunity, Sep 2017, International Symposium in Freiburg, Germany. 科研项目 名称 1. 河南省高层次人才计划，主持 2. 引进人才科研启动经费，主持 3. 德国COVID-19专项研究基金，主持 4. 国家自然科学基金委联合基金项目，主要参与 5. 德国自然科学基金，主要参与 6. 德国研究联合会重大专项，参与