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个人简介Personal Profile 本科和博士毕业于华中师范大学化学学院,获华中师范大学优秀博士论文;2011年-2014年在美国马里兰大学从事博士后研究;2014年加入西北大学化学与材料科学学院,任教授、博导。独立工作期间,先后荣获陕西省青年百人计划、Thieme Chemistry Journals Award、教育部霍英东青年教师基金、陕西省杰出青年科学基金、国家自然科学基金委优秀青年科学基金;主持包括国家自然科学基金面上项目(4项)、陕西省自然科学基金面上项目(1项)和陕西省教育厅重点科研计划(1项)等科研项目。主要围绕基于大环分子体系的仿生超分子化学领域开展研究工作,发展了在生物兼容环境中仿生超分子体系的构建及其在生物分子的仿生识别行为、手性传递与放大机制以及光催化转化与光动力治疗等方面的应用;迄今以第一或通讯作者发表J. Am. Chem. Soc., Angew. Chem. Int. Ed., CCS Chem.等期刊论文五十余篇;相关研究成果获陕西高等学校科学技术研究优秀成果一等奖(排名第一)和陕西省自然科学一等奖(排名第三)。 学习和工作经历: 2014年-今:教授,博导,西北大学,化学与材料科学学院。 2017年-2018年:国家公派访问学者,美国犹他大学,化学系,合作导师:Peter Stang教授。 2011年-2014年:博士后,美国马里兰大学,化学与生物化学系,合作导师:Lyle Isaacs教授。 2006年-2011年:理学博士(有机化学),华中师范大学,化学学院,导师:吴安心教授。 2002年-2006年:理学学士(应用化学),华中师范大学,化学学院。 基金项目: 国家自然科学基金委优秀青年科学基金 陕西省杰出青年科学基金 教育部霍英东高校青年教师基金 陕西省百人计划(青年项目) 荣誉奖项: 陕西省优秀博士学位论文指导教师 全国超分子化学学术讨论会学术新星奖(全国大环化学暨超分子化学学术讨论会学术委员会和Angewandte Chemie编委会) 大环芳烃超分子化学学术新星奖(2020年度,第十届大环芳烃超分子化学学术研讨会) 陕西省化学优秀青年奖(陕西省化学会) 西北大学2022年度科研奖(团队奖) 陕西高等学校科学技术研究优秀成果一等奖(排名第一) 陕西省自然科学一等奖(排名第三) 西北大学2021年度科研奖(个人奖) 西北大学优秀博士学位论文指导教师 西北大学优秀硕士学位论文指导教师 西北大学2019-2020教学年度优秀教师 Thieme Chemistry Journals Award 华中师范大学优秀博士论文 学术兼职: 中国化学会第三十一届理事会超分子化学专业委员会委员 中国化学会高级会员 中国感光学会青年理事会理事 Chinese Chemical Letter高级编委 Aggregate青年顾问编委 研究方向: 1、新颖水溶性阳离子型荧光大环分子的合成及生物分子识别研究; 2、基于大环分子识别的刺激响应型超分子组装体系的建立与应用; 3、基于大环的超分子框架材料:构筑、性质研究以及功能的应用。 近年来,课题组针对当前生物分子识别准确性差、手性信息响应缺失等难点和瓶颈问题,通过开发水溶性大环超分子人工体系,系统开展了生物分子识别与手性响应机制的新原理和新方法研究,提出了自适应手性识别与响应的机理,实现了氨基酸、核苷、多肽、蛋白质以及DNA等生物分子的选择性识别与手性信号响应,为生物分子检测与监测机制研究建立了一类人工仿生识别的超分子体系。 毕业学生(就业或升学单位): 博士毕业生: 2019年:鱼洋(西安交通大学) 2021年:李亚雯(西安交通大学)、王聘聘(枣庄学院) 2022年:程琳(西北大学) 2023年:段红红(保密单位) 硕士毕业生: 2017年:李杰 2018年:王聘聘(西北大学) 2019年:张蓓琳(西北工业大学) 2020年:李晨阳(陕西能源职业技术学院)、段红红(西北大学) 2021年:年浩(南方科技大学)、张海洋(陕西隆基乐叶光伏科技有限公司)、秦春艳(山西稷王中学) 2022年:段燕娟(天津凯莱英医药)、王玲 2023年:田萍、马焕青 本科毕业生: 2020年:敖宛彤(丹麦哥本哈根大学),金慧琳(比利时布鲁塞尔自由大学) 科研成果: 独立工作(2014-今): 55. 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Duan, Y.; Wang, J.; Cheng, L.; Duan, H.; Tian, P.; Zhang, Y.*; Cao, L.* Fluorescent, Chirality-Responsive, and Water-Soluble Cage as a Multifunctional Molecular Container for Drug Delivery. Org. & Biomole. Chem. 2022, 20, 3998-4005. https://pubs.rsc.org/en/content/articlelanding/2022/ob/d2ob00520d 45. Li, Y.; Yan, C.; Li, Q.; Cao, L.* Successive Construction of Cucurbit[8]uril-Based Covalent Organic Frameworks from a Supramolecular Organic Framework through Photochemical Reactions in Water. Sci. China Chem. 2022, 65, 1279-1285. http://engine.scichina.com/doi/10.1007/s11426-022-1231-5 44. Duan, H.; Cao, F.; Zhang, M.; Gao, M.; Cao, L.* On-Off-On Fluorescence Detection for Biomolecules by a Fluorescent Cage through Host-Guest Complexation in Water. Chin. Chem. Lett. 2022, 33, 2459-2463. https://www.sciencedirect.com/science/article/pii/S1001841721009426 43. 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Chin. Chem. Lett. 2021, 32, 3531-3534. https://www.sciencedirect.com/science/article/pii/S1001841721003107 39. Xu, W.; Duan, H.; Chang, X.; Wang, G.; Hu, D.; Wang, Z.; Cao, L.*; Fang, Y.* Polyanion and Anionic Surface Monitoring in Aqueous Medium Enabled by an Ionic Host-Guest Complex. Sensors and Actuators B: Chemical, 2021, 340, 129916. https://www.sciencedirect.com/science/article/pii/S0925400521004858 38. Duan, H.; Cao, F.; Hao, H.; Bian, H.; Cao, L.* Efficient Photoinduced Energy and Electron Transfers in a Tetraphenylethene-Based Octacationic Cage through Host-Guest Complexation. ACS Appl. Mater. & Interfaces 2021, 13, 16837-16845. https://pubs.acs.org/doi/10.1021/acsami.1c01867 37. Zhang, H.; Cheng, L.; Nian, H.; Du, J.; Chen, T.; Cao, L.* Adaptive Chirality of Achiral Tetraphenylethene-Based Tetracationic Cyclophanes with Dual Responses of Fluorescence and Circular Dichroism in Water. Chem. Commun. 2021, 57, 3135-3138. https://doi.org/10.1039/d1cc00303h 36. 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Wang, P.; Miao, X.; Meng, Y.; Wang, Q.; Wang, J.*; Duan, H.; Li, Y.; Li, C.; Liu, J.; Cao, L.* Tetraphenylethene-Based Supramolecular Coordination Frameworks with Aggregation-Induced Emission for Artificial Light-Harvesting System. ACS Appl. Mater. & Interfaces 2020, 12, 22630-22639. https://pubs.acs.org/doi/pdf/10.1021/acsami.0c04917 32. Li, Y.; Qin, C.; Li, Q.; Wang, P.; Miao, X.; Jin, H.; Ao, W.; Cao, L.* Supramolecular Organic Frameworks with Controllable Shape and Aggregation-Induced Emission for Tunable Luminescent Materials Through Aqueous Host-Guest Complexation. Adv. Opt. Mater. 2020, 1902154. https://onlinelibrary.wiley.com/doi/abs/10.1002/adom.201902154 31. Nian, H.; Li, A.; Li, Y.; Cheng, L.; Wang, L.; Xu, W.; Cao, L.* Tetraphenylethene-Based Tetracationic Dicyclophanes: Synthesis, Mechanochromic Luminescence, and Photochemical Reaction. Chem. Commun. 2020, 56, 3195-3198. https://doi.org/10.1039/d0cc00860e 30. Li, C.; Nian, H.; Dong, Y.*; Li, Y,; Zhang, B.; Cao, L.* Tetraphenylethene-Based Platinum(II) Bis-Triangular Dicycles with Tunable Emissions. Inorg. Chem. 2020, 59, 5713-5720. https://pubs.acs.org/doi/abs/10.1021/acs.inorgchem.0c00505 29. Li, C.; Zhang, B.; Dong, Y.*; Li, Y.; Wang, P.; Yu, Y.; Cheng, L.; Cao, L.* A Tetraphenylethene-Based Pd2L4 Metallacage with Aggregation-Induced Emission and Stimuli-Responsive Behavior. Dalton Trans. 2020, 49, 8051-8055. https://pubs.rsc.org/en/content/articlelanding/2020/DT/D0DT00469C#!divAbstract 28. Li, Y.; Dong, Y.; Cheng, L.; Qin, C.; Nian, H.; Zhang, H.; Yu, Y.; Cao, L.* Aggregation-Induced Emission and Light-Harvesting Function of Tetraphenylethene-Based Tetracationic Dicyclophane. J. Am. Chem. Soc. 2019, 141, 8412-8415 https://doi.org/10.1021/jacs.9b02617 27. Cao, L.*; Wang, P.; Miao, X.; Duan, H.; Wang, H.; Dong, Y.; Ma, R.; Zhang, B.; Wu, B.; Li, X.; Stang, P. J. 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(SCI, IF = 2.8) 1. 曹利平; 高蒙; 李义涛; 丁娇阳; 吴彦东; 祝艳平; 佘能芳; 吴安心* 二元组装体集群时的高选择性杂化重组行为. 中国科学B辑: 化学, 2009, 39, 343-349. (国家核心期刊) 参与编写专著 1. Cao, L.; Zhao, J.; Yang, D.; Yang, X.-J.; Wu, B.* Hydrogen Bonding-Driven Anion Recognition in Hydrogen Bonded Supramolecular Structures. Springer-Verlag Berlin Herdelberg, 2015, DOI:10.1007/978-3-662-45756-6_5. *通讯作者(Corresponding author)