张其威

导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 张其威 部门： 生命科学技术学院 直属机构： 病原微生物研究院 性别： 男 职务： 副院长 职称： 教授 学位： 博士 毕业院校： 武汉大学 电子邮箱： zhangqw@jnu.edu.cn 办公地址： 梁仲景楼7楼 通讯地址： 广东省广州市天河区黄埔大道西601号暨南大学梁仲景楼7楼 邮编： 510632 荣誉奖励： 省级青年人才 联系方式 个人简介 官网介绍：https://iommb.jnu.edu.cn/2020/1014/c23331a520845/page.htm       暨南大学生命科学技术学院教授/博导，副院长，病毒致病及防控教育部重点实验室方向三负责人；获武汉大学微生物学学士、病毒学国家重点实验室博士、香港大学医学院微生物系博士后，哈佛大学医学院访问学者、广东特支计划“青年拔尖人才”、广东省高校优秀青年教师、广州市珠江科技新星，主要研究方向包括腺病毒的分子进化、致病机制、新型腺病毒载体疫苗等。承担国家重点研发计划课题1项、国家自然科学基金重大研究计划1项，国自然面上项目和青年基金4项，科技部外国专家项目2项，广东省重点研发计划1项，广州实验室重点项目课题1项；在New England Journal of Medicine，Nature Communication，Signal Transduct Target Ther （3篇）, Journal of Virology（7篇）, Vaccine（2篇），Emerging Infectious Diseases, Emerg Microbes & Infect（2篇）, Journal of Medical Virology（6篇）等国际学术刊物上发表70多篇研究论文，其中Top期刊26篇，影响因子大于5的30篇，影响因子大于10的15篇，论文引用6000多次（ESI高被引论文5篇），担任Military Medical Research、Virologica Sinica、Microbes & Immunity期刊Editor, mBio特邀Editor, 参编科学出版社《临床病毒学》，Elsevier出版社2023年《Molecular Medical Microbiology》英文版。获武汉市科技成果奖、深圳市科协优秀自然科学学术论文奖，Springer Nature 2023年度最佳论文奖（STTT），第一发明人申请发明专利7项（授权3项）。目前担任国家和广东省重大人才项目评审专家，教育部学位中心评审专家，中国微生物学会病毒学专业委会委员，NCBI人类腺病毒研究组委员，中华预防医学会疫苗与免疫分会委员，中国疫苗行业协会疫苗学教育专委会委员和疫苗基础研究专委会委员，中国食品药品企业质量安全促进会疫苗及生物制品评价与标准专委会委员，广东省应急管理专家委员会委员，2020年广东省战“疫”专家组成员，中国腺病毒研究协作组发起人和负责人；担任第13届国际腺病毒大会分会主持人，首届全国腺病毒学术研讨会大会共同主席，第四届全国病毒学青年学者学术研讨会大会共同主席。在教学方面，指导学生参加国家大学生创新创业训练项目、 广东省“攀登计划”大学生科技创新项目、“挑战杯”大学生科技竞赛、广东省大学生预防医学实验技能大赛，获评暨南大学优秀研究生导师。担任粤港澳大湾区高校在线开放课程《医学微生物学》主讲人，广东省精品开放课程《走进微生物世界》主讲人，暨南大学研究生课程《高级病毒学》负责人，本科生课程《众论生命科学》，研究生《生物学前沿》《生物医药产业创新》《发展中国家传染病防治技术培训班》主讲教师，八年制医学生导师。         招聘微生物学（病毒学）、分子生物学、免疫学、流行病学、兽医学、药学等研究方向的硕士生、博士生、博士后、青年高层次人才若干名，有意者请随时邮件咨询： zhangqw@jnu.edu.cn。   学习经历 香港大学 李嘉诚医学院，微生物系 博士后武汉大学 病毒学国家重点实验室，病毒学 博士武汉大学 生命科学学院，微生物学 本科学士 工作经历 （1）暨南大学，教授，博导，副院长，高层次引进人才。（2）哈佛大学医学院，访问学者（3）南方医科大学，病原生物学 教授 研究方向 1. 病毒分子进化：研究病毒在流行传播过程中基因组的突变、重组规律和流行趋势，为疾病防控策略的制定提供重要依据。2. 病毒感染致病机制研究：通过细胞、免疫、分子层面研究，阐明不同呼吸道病毒感染引起重症的机制，为临床诊治提供科学依据。3. 动物病毒跨种传播机制研究：研究动物病毒跨种传播感染人体的分子机制，为人兽共患病的防控提供理论依据。4. 腺病毒载体疫苗研究：开发新型腺病毒载体及应用平台，以替代目前所用的人腺病毒载体，用于新的病毒疫苗和基因治疗。5. 抗病毒药物研究：筛选鉴定高效低毒广谱的抗呼吸道病毒的小分子药物，以解决目前临床无特效抗病毒药物的问题。My research interests are the genomics, epidemiology, novel vectors, antivirals and vaccines for human adenoviruses (AdVs) and SARS-CoV-2, etc.  1. Recently, more and more human acute respiratory disease outbreaks caused by AdV have emerged in schools, families and military. We are developing effective antiviral drugs and vaccine candidates using new strategies and optimal animal models. 2. Analysis of whole-genome sequences for these emergent AdVs and identification of the homologous recombination and transmission mechanism during adenovirus evolution. 3. The cross-species transmission (CST) of animal AdVs is a potential threat to human health and animal adenovirus vector development. The study of CST of AdVs in simians provides a scientific basis for the prevention and control of adenovirus diseases as well as for the novel simian AdV vector development.  4. Research on the pathogenic mechanism of viral infection: Through research at the cellular, immune and molecular levels, the mechanism of severe illness caused by different types of respiratory virus infection will be elucidated, and an important reference will be provided for the research and development of antiviral drugs. 主要论文 Wendong Lan, Lulu Quan, Yiqiang Li, Junxian Ou, Biyan Duan, Ting Mei, Xiao Tan, Weiwei Chen, Liqiang Feng, Chengsong Wan, Wei Zhao, James Chodosh, Donald Seto and Qiwei Zhang*. Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines. Journal of Virology, 2023, 97(10): e0101423. （病毒学一区，Top期刊）https://mp.weixin.qq.com/s/-j4LKQ1RaQazAJJOKgS7kQ  Shanshan Zhao#, Xiaowei Wu#, Zhihong Tan, Yi Ren, Lian Li, JunxianOu, Ying Lin, Hongbin Song, Liqiang Feng, Donald Seto, Jianguo Wu, Qiwei Zhang* and Zhili Rong*. Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs. Journal of Virology. 2023 May 1;e0020923. （病毒学一区，Top期刊）https://mp.weixin.qq.com/s/I7THAUzJvdUmawfGEUsLvQQiwei Zhang*, Donald Seto. Chimpanzee Adenovirus Vector Ebola Vaccine--Preliminary Report. New England Journal of Medicine. 2015, 373(8): 775-776. (医学一区，Top期刊，IF: 176.079) http://www.smu.edu.cn/info/1139/1400.htm Junxian Ou, Wendong Lan, Xiaowei Wu, Tie Zhao, Biyan Duan, Peipei Yang, Yi Ren, Lulu Quan, Wei Zhao, Donald Seto, James Chodosh, Zhen Luo, Jianguo Wu*, and Qiwei Zhang*. Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events. Signal Transduction and Targeted Therapy 2022 April 26; 7(1): 138.  (医学一区，Top期刊，IF: 38.104, ESI高被引论文) https://mp.weixin.qq.com/s/CtYJeXoTf4_1sYCyz-90Fw   Junxian Ou, Zhonghua Zhou, Ruixue Dai, Jing Zhang, Shan Zhao, Xiaowei Wu, Wendong Lan, Yi Ren, Lilian Cui, Qiaoshuai Lan, Lu Lu, Donald Seto, James Chodosh, Jianguo Wu, Gong Zhang*, Qiwei Zhang*. V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity. Journal of Virology, 2021, 95(16):e0061721. Doi:10.1128/JVI.00617-21. （病毒学一区，Top期刊，ESI高被引论文）https://mp.weixin.qq.com/s/TEqgtrqDLT3egH0KhF2zsQ  Junxian Ou, Jianguo Wu and Qiwei Zhang*. Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants. Signal Transduction and Targeted Therapy.  2022, 7(1): 322. Signal Transduction and Targeted Therapy 2022 April 26; 7(1): 138. (医学一区，Top期刊，IF: 38.104) https://www.nature.com/articles/s41392-022-01179-5  Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo*, Qiwei Zhang* and Jianguo Wu*. HIF-1alpha promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19. Signal Transduct Target Ther. 2021, 6(1): 308. (医学一区，Top期刊，IF: 38.104) https://iommb.jnu.edu.cn/2021/0820/c16001a641843/page.htm     J. Wei, N. Zang, J. Zhang, Y. He, H. Huang, X. Liu, X. Xu, L. Ren, Y. Deng, J. Wu, D. Seto, W. Zhong, Q. Zhang* and E. Liu*. Genome and proteomic analysis of risk factors for fatal outcome in children with severe community-acquired pneumonia caused by human adenovirus 7. Journal of Medical Virology.  2023, 95(11): e29182. (IF: 12)  https://mp.weixin.qq.com/s/y6SZ7aZRig52XHadQbdCKQ Xiaowei Wu#, Jing Zhang#, Wendong Lan#, Lulu Quan, Junxian Ou, Wei Zhao, Jianguo Wu, Patrick C. Y. Woo, Donald Seto* and Qiwei Zhang*. Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber. Frontiers in Microbiology.  2022, 13: 911694. (生物学二区，Top期刊) https://mp.weixin.qq.com/s/OHSCIf3SAVT7pVWZGTcmrg  Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li and Jianguo Wu. SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nature Communications. 2021, 12(1): 4664. (综合一区，IF: 17.694，Top期刊 ESI高被引论文) Zhixin Liu, Xiao Xiao, Xiuli Wei, Jian Li, Jing Yang, Huabing Tan, Jianyong Zhu, Qiwei Zhang, Jianguo Wu and Long Liu. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol. 2020, 92(6): 595-601. （IF：20.693, ESI高被引论文） G. Li, Y. Fan, Y. Lai, T. Han, Z. Li, P. Zhou, P. Pan, W. Wang, D. Hu, X. Liu, Q. Zhang and J. Wu. Coronavirus Infections and Immune Responses. J Med Virol.  2020, 92(4): 424-432. IF：20.693, ESI高被引论文） Z. Luo, Y. Liang, M. Tian, Z. Ruan, R. Su, M. A. Shereen, J. Yin, K. Wu, J. Guo, Q. Zhang*, Y. Li* and J. Wu*. Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication. J Med Virol.  2023, 95(2): e28527.Z. Lei, L. Zhu, P. Pan, Z. Ruan, Y. Gu, X. Xia, S. Wang, W. Ge, Y. Yao, F. Luo, H. Xiao, J. Guo, Q. Ding, Z. Yin, Y. Li, Z. Luo, Q. Zhang*, X. Chen* and J. Wu*. A vaccine delivery system promotes strong immune responses against SARS-CoV-2 variants. J Med Virol.  2023, 95(2): e28475.Pan Pan, Geng Li, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Zizhao Lao, Yaohua Fan, Keli Chen, Zhihao Ding, Wenbiao Wang, Pin Wan, Muhammad Adnan Shereen, Zhen Luo, Xulin Chen, Qiwei Zhang, Luping Lin and Jianguo Wu. DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction. PLOS Pathogens.  2021, 17(7): e1008603. (医学一区，Top期刊) Shuping Jing#, Jing Zhang#, Mengchan Cao, Minhong Liu, Yuqian Yan, Shan Zhao, Na Cao, Junxian Ou, Kui Ma, Xiangran Cai, Jianguo Wu, Ya-Fang Mei, and Qiwei Zhang*. Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease. Emerging Infectious Diseases. 2019, 25(9): 1754-1756 (医学一区，Top期刊，IF: 16.126)          http://blog.sciencenet.cn/home.php?mod=space&uid=51164&do=blog&id=1194147 Jing Zhao#, Shan Zhao#, Junxian Ou, Jing Zhang, Wendong Lan, Wenyi Guan, Xiaowei Wu, Yuqian Yan, Wei Zhao, Jianguo Wu, James Chodosh and Qiwei Zhang*. COVID-19: Coronavirus Vaccine Development Updates. Frontiers in Immunology.  2020, 11(3435): 602256. （医学二区，Top期刊： IF 8.786，引用>100次）   http://mrw.so/5VXG6N  Zhonghua Zhou, Ziyi Yang, Junxian Ou, Hong Zhang, Qiwei Zhang*, Ming Dong* and Gong Zhang*. Temperature Dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome. Computational and Structural Biotechnology Journal.  2021，19:161-167.（生物学二区，IF：7.271）           http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2021-01/06/content_460576.htm?div=-1      http://stdaily.com/index/kejixinwen/2020-12/28/content_1065892.shtml      https://enapp.chinadaily.com.cn/a/202101/06/AP5ff5600da310f03332f92bf0.html Qiwei Zhang*, Yiqiang Li, Pascal Fender, Bin Yu, Liqiang Feng, Ling Chen and Xianghui Yu*. Editorial: Adenoviral Infection and Immunity, and Adenoviral Vectors for Gene Therapy Applications. Frontiers in Microbiology.  2022, 13: 869059. (生物学二区，Top期刊)       https://www.frontiersin.org/article/10.3389/fmicb.2022.869059  Qiwei Zhang*, Shuping Jing, Zetao Cheng, Zhiwu Yu, Shoaleh Dehghan, Amirhossein Shamsaddini, Yuqian Yan, Min Li, and Donald Seto*. Comparative Genomic Analysis of Two Emergent Human Adenovirus Type 14 Respiratory Pathogen Isolates in China Reveals Similar yet Divergent Genomes. Emerging Microbes & Infections, 2017, 6, e93. (医学二区，IF: 19.568)   https://mp.weixin.qq.com/s/mmFqCD8VxFhh2No7IEwq6g  Qiwei Zhang*, Seto D, Zhao S, Zhu L, Zhao W, Wan C*. Genome Sequence of the First Human Adenovirus Type 14 Isolated in China.  Journal of Virology, 2012, 86(12): 7019-7020（Top期刊） Qiwei Zhang*, Donald Seto, Bin Cao, Suhui Zhao, and Chengsong Wan*. Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China.  Journal of Virology, 2012，86(22)：12441-12442（Top期刊） Donald Seto, Chodosh J, Brister JR, Jones MS, Members of the Adenovirus Research Community (Qi-Wei Zhang et al). Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses. Journal of Virology, 2011, 85(11): 5701-5702. （病毒学一区，Top期刊，IF: 6.549）. Wei Tang, Yueyue Li, Qiaoyun Song, Ziqin Wang, Manmei Li, Qiwei Zhang, Ying Wang, Wencai Ye and Yaolan Li. Mechanism of Cross-Resistance to Fusion Inhibitors Conferred by the K394R Mutation in Respiratory Syncytial Virus Fusion Protein. Journal of Virology. 2021, 95(20): e0120521. (病毒学一区，Top期刊) Hong-Ling Jia, Peng Li, Hong-Jie Liu, Jia-Yong Zhong, Peng-Zhe Qin, Wen-Zhe Su, Ying-Feng Zheng, Kui-Biao Li, Qing Zeng, Jin-Hui Li, Li-Zhong Li, Lan Cao, Ji-Bin Wu, Yi-Yun Chen, Lei-Li Jia, Hong-Bin Song, Qi-Wei Zhang, Guang Yang, Chun-Xia Jing, Xiao-Chen Bo, Zhou-Bin Zhang, Biao Di, Chuan-Le Xiao and Ming Ni. Genomic Elucidation of a COVID-19 Resurgence and Local Transmission of SARS-CoV-2 in Guangzhou, China. Journal of Clinical Microbiology.  2021, 59(8): e0007921. （Top期刊，IF：11.677）Tie Zhao, Chunhui Wang, Biyan Duan, Peipei Yang, Jianguo Wu* and Qiwei Zhang*. Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming. Frontiers in Microbiology.  2022, 13: 863802. (生物学二区，Top期刊) Tie Zhao, Yi Ren, Jianguo Wu* and Qiwei Zhang*. Possible Mechanism of SARS-CoV-2 Nsp1-Mediated Control of Viral Gene Expression. Frontiers in Cellular and Infection Microbiology.  2022, 12: 881749. Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang*, Zhen Luo* and Jianguo Wu*. AP-1 signaling pathway promotes pro-IL-1beta transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection. Virulence.  2022, 13(1): 502-513. Xiaojing Wen, Li Zhang, Shan Zhao, Qiang Liu, Wenyi Guan, Jiajing Wu, Qiwei Zhang*, Hongling Wen* and Weijin Huang*. High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors. Frontiers in Cellular and Infection Microbiology. 2021, 11: 10.3389/fcimb.2021.767578. （医学二区，IF：5.293） Shan Zhao, Wenyi Guan, Kui Ma, Yuqian Yan, Junxian Ou, Jing Zhang, Zhiwu Yu, Jianguo Wu and Qiwei Zhang*. Development and Application of a Fast Method to Acquire the Accurate Whole-Genome Sequences of Human Adenoviruses. Frontiers in Microbiology.  2021, 12: 661382. （生物学二区，Top期刊，IF: 6.064）         https://mp.weixin.qq.com/s/4DZrdIERFP_h6b2vuwjo-w  Wenyi Guan, Wendong Lan, Jing Zhang, Shan Zhao, Junxian Ou, Xiaowei Wu, Yuqian Yan, Jianguo Wu and Qiwei Zhang*. COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine. Virologica Sinica.  2020: 10.1007/s12250-12020-00297-12250. （医学二区，IF：6.947)    http://m6z.cn/6rP9o7  Hongying Fan, Zhenhui Chen, Ruqin Lin, Yangyang Liu, Xianbo Wu, Santhosh Puthiyakunnon, Ye Wang, Bo Zhu, Qiwei Zhang*, Yang Bai* and Fachao Zhi*. Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model. mSystems.  2019, 4(4): e00305-00319. （医学二区，IF: 6.496） Yuqian Yan, Junxian Ou, Shan Zhao, Kui Ma, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jing Zhang, Bao Zhang, Wei Zhao, Chengsong Wan, Weifeng Shi, Jianguo Wu, Donald Seto, Zhiwu Yu* and Qiwei Zhang*. Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017–2018 Season. Frontiers in Microbiology. 2020, 11(1079): 10.3389/fmicb.2020.01079. （生物学二区，Top期刊） Zetao Cheng#, Yuqian Yan#, Shuping Jing, Wen-Gang Li, Wei-Wei Chen, Jing Zhang, Min Li, Shan Zhao, Na Cao, Junxian Ou, Suhui Zhao, Xianbo Wu*, Bin Cao*, Qiwei Zhang*. Comparative Genomic Analysis of Re-emergent Human Adenovirus Type 55 Pathogens Associated With Adult Severe Community-Acquired Pneumonia Reveals Conserved Genomes and Capsid Proteins. Frontiers in Microbiology, 2018, 9(1180). （生物学二区，Top期刊）https://mp.weixin.qq.com/s/B-dq-f59FgNvsJlHzKOiXQ  Jing Zhang, June Kang, Shoaleh Dehghan, Siddharth Sridhar, Susanna Lau, Junxian Ou, Patrick Woo, Qiwei Zhang*, Donald Seto*. A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations. Viruses, 2019, 11(2):129. （医学二区，IF：5.048）http://m6z.cn/5B0s7B  Haibin Pan, Yuqian Yan, Jing Zhang, Shan Zhao, Liqiang Feng, Junxian Ou, Na Cao, Min Li, Wei Zhao, Chengsong Wan, Ashrafali M Ismail, Jaya Rajaiya, James Chodosh, Qiwei Zhang*. Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly. Viruses, 2018, 10(10):568. （医学二区，IF：5.048）https://mp.weixin.qq.com/s/pOAjdDbLK45EY7quxFoKIw  Jing Zhang, Kui Ma, Xiangyu Wang, Yinbo Jiang, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Heping Zheng, Bin Yang, Chengsong Wan, Wei Zhao, Jianguo Wu* and Qiwei Zhang*. Desmoglein 2 (DSG2) is a Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia. Virologica Sinica. 2021, 36(3). DOI: 10.1007/s12250-021-00414-7（医学二区，IF：6.947） Qiwei Zhang, Su X, Seto D, Zheng B-j, Tian X, Sheng H, Li H, Wang Y, Zhou R*. Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector.  Vaccine, 2009, 27(8): 1145-1153.  (医学二区，Top期刊，IF:3.485) Qiwei Zhang, Su X, Gong S, Zeng Q, Zhu B, Wu Z, Peng T, Zhang C, Zhou R. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China.  Journal of General Virology 2006, 87(6): 1531-1541.  (IF:3.529) Yuqian Yan, Shuping Jing, Liqiang Feng, Jing Zhang, Zhiwei Zeng, Min Li, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jianguo Wu, Donald Seto and Qiwei Zhang*. Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”. Virologica Sinica.  2021，36(3): 354-364. （医学二区，IF：6.947）https://mp.weixin.qq.com/s/H0hsYKmfJSiMPlzEIF1_IQ   主要著作 美国微生物学会《Clinical Virology》中文版，科学出版社，2012.《Molecular Medical Microbiology 》英文版，Elsevier出版社，2023年. 承担课题      国家自然科学基金重大研究计划项目：新冠病毒刺突蛋白变异与免疫逃逸机制的研究      国家重点研发计划：国际新发病毒变异变迁规律及靶点模型研究      广东省重点研发计划应急攻关项目：口服腺病毒载体新冠疫苗的研发      广州实验室重点项目课题：新冠病毒感染机体免疫应答平衡     中央高校交叉学科专项：广谱抗人呼吸道腺病毒感染的中药小分子化合物研究国家自然科学基金面上项目：“人腺病毒和猴腺病毒的跨物种传播与基因组重组机制的研究”国家自然科学基金面上项目：“人腺病毒免疫抑制小鼠感染模型的建立及其致病机制的研究”国家自然科学基金面上项目：“我国新发现的14、55型腺病毒的生物学特性与基因组重组机制的研究”国家自然科学基金青年项目：“人3型、7型腺病毒双价减毒重组疫苗候选株的构建及免疫原性研究”广东省自然科学基金面上项目：大黄素和黄连素抗人3、4、7、14、55型腺病毒的研究广东省自然科学基金面上项目：“广谱抗人呼吸道腺病毒RNAi药物的研究”广东省自然科学基金面上项目：“人3、4、7型腺病毒三价减毒重组疫苗候选株的构建及免疫原性研究”广东省自然科学基金团队项目，子课题：HIV潜伏激活的分子机制与新型靶向性潜伏激活剂的研究广州市健康医疗协同创新重大专项 “病毒感染重症救治的特异性被动免疫应用研究及腺病毒单克隆抗体药物研发”(201803040004)子课题广州市健康医疗协同创新重大专项 “呼吸道重要传染病疫苗的制备及临床研究”(201803040007)子课题, 广州市健康医疗协同创新重大专项“呼吸道新发突发及重大传染病综合防诊治”子课题香港大学博士后基金:Construction and Characterization of a Full-Length Infectious Molecular Clone from the HIV Type 1 CRF08_BC Isolated in China 发明专利 (1)     《一种病毒基因组核酸快速提取试剂盒及其使用方法》，授权专利：ZL 202110657003.2 (2)     《一种人3型腺病毒复制缺陷型重组病毒、构建方法及应用》，授权专利：ZL202010055543.9(3)     《人呼吸道合胞病毒荧光定量PCR试剂盒及其检测方法》，授权专利：ZL200310111382.7 讲授课程 担任粤港澳大湾区高校在线开放课程《医学微生物学》主讲人，广东省精品开放课程《走进微生物世界》主讲人，暨南大学研究生课程《高级病毒学》负责人，本科生课程《众论生命科学》，研究生《生物学前沿》《生物医药产业创新》主讲教师。 荣誉奖励 省级青年人才 社会职务 国家和广东省重大人才项目评审专家，教育部学位中心评审专家，中国微生物学会病毒学专业委会委员，NCBI人类腺病毒研究组委员，中华预防医学会疫苗与免疫分会委员，中国疫苗行业协会疫苗学教育专委会委员和疫苗基础研究专委会委员，中国食品药品企业质量安全促进会疫苗及生物制品评价与标准专委会委员，广东省应急管理专家委员会委员，2020年广东省战“疫”专家组成员，中国腺病毒研究协作组发起人和负责人；担任第13届国际腺病毒大会分会主持人，首届全国腺病毒学术研讨会大会共同主席，第四届全国病毒学青年学者学术研讨会大会共同主席。