王星文

个人信息 科学研究 论文著作 新建主栏目 基本信息 名称 王星文，博士，副研究员，黑龙江省优秀青年基金获得者，黑龙江省青年托举项目获得者。近年来一直从事肿瘤转移与耐药相关分子机制研究，研究成果发表于肿瘤学顶级刊物Cancer Cell以及肿瘤学经典刊物Cell Death Differ、Molecular Therapy、Research、Oncogene、Cancer Letters等，共计21篇，其中以第一作者或共同第一作者发表SCI论文10篇，中文核心期刊论文1篇，参编英文论著1部，获国家发明专利1项。主持国家自然科学基金青年项目、黑龙江省自然科学基金优秀青年项目、黑龙江省青年托举工程项目（每年20人）、中国博士后科学基金面上项目（一等，资助率不超过3％）以及中国博士后科学基金特别资助项目（全国每年不超过800人），参与国家重点研发计划，国自然原创探索专项项目等，担任J Genet Genomics等多个SCI杂志的特约审稿人。 工作经历 名称 2022.01-至今，哈尔滨工业大学，生命科学与技术学院，副研究员 2019.07-2021.12，哈尔滨工业大学，生命科学与技术学院，助理研究员 2019.07-至今，哈尔滨工业大学，机电工程学院，博士后 教育经历 名称 2015.09至2019.07，哈尔滨工业大学，生命科学与技术学院，博士 (导师：胡颖教授） 2013.09至2015.06，哈尔滨工业大学，生命科学与技术学院，硕士 (导师：胡颖教授） 2009.09至2013.07，哈尔滨师范大学，生命科学与技术学院，本科 学术兼职 名称 担任Journal of Genetics and Genomics、Oncology Letters、International Journal of Oncology、Molecular Medicine Reports等SCI杂志审稿人 研究领域 名称 主要研究方向（详细介绍见胡颖教授主页http://homepage.hit.edu.cn/huying） 肿瘤转移与耐药分子机制研究 非编码RNA在肿瘤中的表达及其调控机制研究 科研项目 名称 1. 国家自然科学基金青年项目， 2021/01-2023/12，在研，主持。 2. 黑龙江省自然科学基金优秀青年项目， 2021/07-2024/06，在研，主持。 3. 中国博士后科学基金特别资助项目，2021/06-2023/06，在研，主持。 4. 中国博士后科学基金面上项目（一等）， 2021/01-2022/12，在研，主持。 5. 黑龙江省青年科技人才托举工程项目， 2023/12-2025/12，在研，主持。 专利 名称 1. 胡颖，王星文，赵坤明. 长非编码RNA linc00637的应用. CN201810429626.2 代表性论文 名称 17.Xingwen Wang#, Yi Zhang#, Qingyu Lin, Kunming Zhao, Dantong Zhu, Ying Hu,* Mitochondria-localized lncRNA HITT inhibits fusion by attenuating formation of mitofusin-2 homo- or heterotypic complexes. J Biol Chem. 2023, 299(2):102825. 16.Shanliang Zheng#, Xingwen Wang#, Hao Liu, Dong Zhao, Qingyu Lin, Qinghua Jiang, Li Li* and Ying Hu*, iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.Cell Death and Differentiation, 2022,30(2):327-340.（IF=12.067，co-first author） 15.Shanliang Zheng, Xingwen Wang, Dong Zhao, Hao Liu and Ying Hu, Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications. Trends in Cell Biology. 2022. S0962-8924(22)00174-X. 14.Kunming Zhao#, Xingwen Wang#, Dong Zhao#, Qingyu Lin, Yi Zhang and Ying Hu，lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization. Research, 2022. 2022:9854904.（IF=11.036，co-first author） 13.Hao Liu#, Dong Zhao#, Huayi Li, Wenxin Zhang, Qingyu Lin, Xingwen Wang, Shanliang Zheng, Lei Zhang, Li Li, Shaoshan Hu, Ying Hu. Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization. Cell Death and Disease，2022 Feb 21;13(2):166. 12. Dong Zhao, Shanliang Zheng, Xingwen Wang, Hao Liu, Kunming Zhao, Li Li, Ying Hu. iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation. Oncogene. 2022. 41(13):1944-1958. 11. Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, Ying Hu. iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2%2B homeostasis and control tumor growth and drug resistance. Proc Natl Acad Sci U S A. 2022,119(6):e2111380119. 10. Xingwen Wang#, Shanliang Zheng#, Fan Yang, Wenxin Zhang, Dong Zhao, Xuting Xue, Qingyu Lin, Yunfei He, Guohong Hu and Ying Hu. LncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma. Molecular Therapy, 2022, 8;S1525-0016(22)00014-4. （IF=11.454） 9. Wenjie Ge, Yudong Wang, Shanliang Zheng, Dong Zhao, Xingwen Wang, Xiaoshi Zhang, Ying Hu. Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB. Cell Death and Discovery, 2021, 7(1):195. 8. Xingwen Wang, Dong Zhao, Hui Xie and Ying Hu. Interplay of long non-coding RNAs and HIF-1α: A new dimension to understanding hypoxia-regulated tumor growth and metastasis. Cancer Letters, 2021, 499:49-59. 7. Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Huayi Li, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Hui Xie, Qiong Wu and Ying Hu. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth . Cell Death and Differentiation, 2020, 27(4): 1431-1446. （IF=15.828）CDDPress Monthly Top Picks 6. Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi and Ying Hu. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene, 2020, 39(9): 1860-1874. 5. Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biology.18(3):e3000666. 2020. 4. Huayi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Kunming Zhao, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Ying Hu. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer Letters. 2018,432:121-131.（co-first author） 3. Xingwen Wang, Yiwei Cheng, YiFu Zhu, Huayi Li, Wenjie Ge, Xiaoliang Wu, Kunming Zhao, Jinyang Yuan, Zhenglin Li, Shijian Jiang, Zhengbin Han, Qinghua Jiang, Qiong Wu, Tao Liu, Cheng Zhang, Miao Yu and Ying Hu, Epigenetic Silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation. International Journal of Cancer, 2017.141(7):1422-1433. 2. Wenjie Ge#, Kunming Zhao#, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang and Ying Hu, iASPP Is an Antioxidative Factor and Drives Cancer growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding. Cancer Cell, 2017,32,1–13. 1. Xingwen Wang, Miao Yu, Kunming Zhao, Mengmeng He, Wenjie Ge, Yuhui Sun, Yihua Wang, Haizhu Sun and Ying Hu. Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death and Disese，2016 Dec 8;7(12): e2517.