杜晓华

个人简介 杜晓华，男，博士，研究员，博士生导师。1972年出生于湖北省松滋市。现任浙江工业大学化学工程学院绿色化学与技术学科副主任，兼任浙江省化工学会农药专业委员会主任、中国化工学会农药专业委员会委员、新农药创制与开发国家重点实验室学术委员会委员、浙江省绿色农药清洁生产技术重点实验室副主任等职。主要从事绿色化学合成技术和农药新产品、新工艺研究与开发。已主持国家科技支撑课题、浙江省绿色化工重大专项、企业重大横向等科研项目20余项，发表论文50余篇，获得授权发明专利30余项，荣获中国石油和化学工业联合会科技进步奖一等奖3项、浙江省科学技术奖二等奖2项、中国专利优秀奖2项。 教学与课程 科研项目 1）十三五国家重点研发计划子课题，丙草胺的清洁生产工艺研发，2018~2020,100万。2）十二五国家科技支撑课题，磺草酮的清洁生产技术，2011-1~2015-3，350万。3）浙江省重大科技专项，含氟农药绿色化关键技术研发与应用，2008-1~2011-12，100万。4）浙江省重大科技专项，高效安全除草剂硝磺草酮清洁生产技术研发与应用，2012-9~2014-12，75万。5）浙江省重点科技计划项目，高效安全除草剂磺草酮的绿色合成技术研究与开发，2008.1-2010.12，30万。6）浙江省科技厅重点项目，超高效、安全、广谱除草剂氟噻乙草酯的清洁生产工艺的研究与开发，2004-6~2006-12，25万元。7）  浙江省科技厅重点项目，重要含氟中间体对氨基三氟甲苯的绿色合成技术，2005-4~2006-12，27万。8）  浙江省自然科学基金，固体氧化物和全氟烷磺酸盐协同催化二氧化氮-氧气的绿色硝化反应，2005-1~2006-12，5万元。9）  企业委托项目10余项。 育人成果 已培养博士生7名，硕士生40名。 科研成果 一、科研奖励(1)   浙江省优秀科技工作者，2013.(2)   浙江省科学技术奖二等奖， 2012-04-01，排名:1(3)   中国石油和化学工业联合会科技进步奖一等奖， 2013-10-18，排名:1 (4)   中国专利奖优秀奖，2014-11-01，排名:1(5)   中国石油和化学工业联合会科技进步奖一等奖， 2014-11-05，排名:4(6)   浙江省技术发明奖二等奖，2015，排名：2.(7)  中国专利优秀奖，2018，排名：1二、论文 1.     Xu Ying; Wang Hongtao; Du, Xiaohua*. Design, synthesis, and fungicidal activity of novel N-substituted piperazine-containing phenylpyridines against cucumber downy mildew, PEST MANAGEMENT SCIENCE, DOI:10.1002/ps.6798, 20222.     Cai, Zengfei; Zhang, Wenliang; Cao, Yangyang; Du, Xiaohua*. Synthesis and herbicidal activities of 2-phenylpyridine compounds containing alkenyl moieties, JOURNAL OF HETEROCYCLIC CHEMISTRY, DOI:10.1002/jhet.4464，20223.     Hao Shulin; Cai Zengfei; Cao Yangyang; Du Xiaohua*, Design, synthesis and fungicidal activity of strobilurins containing pyrimidine thioether units, Chinese Journal of Pesticide Science, 23（1）, 60-68, 20214.     Hao, Shulin; Cai, Zengfei; Zhang, Wenliang; Cao, Yangyang; Du, Xiaohua*, A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents, JOURNAL OF HETEROCYCLIC CHEMISTRY, 10.1002/jhet.4367, 20215.     Hao, Shulin; Cai, Zengfei; Cao, Yangyang; Du, Xiaohua*, Design, Synthesis, and Acaricidal Activity of Phenyl Methoxyacrylates Containing 2-Alkenylthiopyrimidine, MOLECULES, 25(15), 10.3390/molecules25153379, 20206.     Ma, Xinpeng; Chen, Jinsha; Du, Xiaohua*, A Continuous Flow Process for the Synthesis of Hymexazol, ORGANIC PROCESS RESEARCH & DEVELOPMENT, 23(6), 1152-1158, , 20197.     Cui Menglong; Du Xiaohua*, Separation and Purification of Glufosinate Through Combination of an Electrodialysis Membrane and a Macroporous Adsorption Resin, CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 35(4), 647-653, 20198.     Cao Yangyang; Cai Zengfei; Zhang Wenliang; Du Xiaohua*, Synthesis and Herbicidal Activity of Novel beta-Methoxyacrylate Derivatives Containing a Substituted Phenylpyridine Moiety, CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 35(6), 1008-1011, 20199.     Cao Yang-Yang; Wang Wei-Wei; Du XiaoHua*, Synthesis, Crystal Structure and Herbicidal Activity of Methyl (E)-alpha(Methoxyimino)-2-((4-(3-chloro-5-(trifluoromethyl)- pyridine-2-yl)phenoxy)methyl)benzeneacetate, CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 38（7）, 1123-1128, 201910.  Cao, Yang-yang; Mao, Da-jie; Wang, Wei-wei; Du, Xiaohua*, Kresoxim-methyl Derivatives: Synthesis and Herbicidal Activities of (Pyridinylphenoxymethylene)phenyl Methoxyiminoacetates, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65（30）, 6114-6121, 201711.  Hu, Chongbo; Liu, Jianhua; Du, Xiaohua*, Synthesis and Insecticidal Activities of N-(tert-Butyl)-N '-fluorobenzoyl-substitutedpyridylcarbonyl Hydrazide Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 36（5）, 1051-1059, 201612.  Tang, Yucai; Zhang, Min; Li, Xiaoqing; Xu, Xiangsheng; Du, Xiaohua*, Tetrabutylammonium Iodide-Catalyzed Radical Alkoxycarbonylation of Activated Alkenes: Synthesis of Isoquinolinedione Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 35（4）, 875-881, 201513.  Tang, Yucai; Zhang, Ye; Wang, Kaifeng; Li, Xiaoqing; Xu, Xiangsheng; Du, Xiaohua*, Tetrabutylammonium iodide-catalyzed oxidative coupling of enamides with sulfonylhydrazides: synthesis of beta-keto-sulfones, ORGANIC & BIOMOLECULAR CHEMISTRY, 13（25）, 7084-7090, 201514.  Mao, Dajie; Hu, Chongbo; Wang, Weiwei; Du, Xiaohua*; Xu, Zhenyuan, Synthesis and Crystal Structure Characterization of (E)-Methyl 2-(Methoxyimino)-2-(2-((3-(6-(Trifluoromethyl) Pyridin-3-yl) Phenoxy) Methyl) Phenyl) Acetate, MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 607（1）, 264-271, 201515.  Xu, Xiangsheng; Tang, Yucai; Li, Xiaoqing; Hong, Guo; Fang, Mingwu; Du, Xiaohua*, Iron-Catalyzed Arylalkoxycarbonylation of N-Aryl Acrylamides with Carbazates, JOURNAL OF ORGANIC CHEMISTRY, 79（1）, 446-451, 201416.  Liu, Jianhua; Li, Yiming; Mao, Dajie; Du, Xiaohua*, Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 34（10）, 2140-2145, 201417.  Li, Yi-Ming; Du, Xiao-Hua; Zhou, Qin-hua; Chen, Shu-Da, A Novel Procedure for the Synthesis of Ammonium Glufosinate, ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 46（6）, 565-568, 201418.  Zhou, Xian-Feng; Du, Xiao-Hua*, (2E,4E)-2-Cyano-5-dipropyl-amino-N,N-dimethyl- penta-2,4-dienamide., Acta crystallographica. Section E, 68（5）, 1311, 201219.  Chen, Jin; Du, Xiaohua*, Novel Synthetic Routes of 3-Methoxypropanal from Glycerol, SYNTHETIC COMMUNICATIONS, 41（9）, 1376-1380, 201120.  Ge, Qianjian; Chen, Liezhong; Du, Xiaohua*, Synthesis and Insecticidal Activities of Pyrazole-heterocyclic Diamides, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 31（9）, 1510-1515, 201121.  Chen, Jin; Ren, Xukang; Li, Zhaobo; Du, Xiaohua*, 2-(2-Nitrophenyl)-1,3-dioxan-5-ol, ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 65, 2852, 200922.  Du, Xiao-Hua; Luo, Da-Wei; Xu, Zhen-Yuan, A Novel Synthesis of Pendimethalin, ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 41（3）, 249-252, 200923.  Du, Xiaohua; Hu, Lihua; Sun, Zuguang; Nie, Siqiao; Xu, Zhenyuan, Synthesis and Bioactivities of Hexahydropyridazine Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 29（8）, 1232-1235, 200924.  Li, Xiao-Qing; Sun, Zu-Guang; Du, Xiao-Hua, 2-Acetyl-N-[3-(trifluoromethyl)phenyl] perhydro-pyridazine-1-carboxamide, ACTA CRYSTALLOGRAPHICA SECTION E, 63, 1665-1666, 200725.  Du, Xiaohua; Li, Xiaoqing; Xu, Zhenyuan, Novel atom-economic nitration of benzene with a nitrogen dioxide-oxygen system using cocatalyst of solid oxides and lanthanide(III) metal triflates, SYNTHETIC COMMUNICATIONS, 37（19-21）, 3741-3749, 200726.  Sun, Zu-Guang; Li, Xiao-Qing; Xu, Wei; Du, Xiao-Hua*, 2-[3-(Trifluoromethyl)phenyl]perhydro1,2,4-triazolo[1,2-a]pyridazine-1,3-dione, ACTA CRYSTALLOGRAPHICA SECTION E, 63, 3840,200727.   Li, Xiao-Qing; Sun, Zu-Guang; Du, Xiao-Hua*, N-[3-(Trifluoromethyl)phenyl]perhydro-pyridazine-1-carboxamide, ACTA CRYSTALLOGRAPHICA SECTION E, 63, 1663-1664, 200728.  Li, Xiao-Qing; Du, Xiao-Hua; Xu, Zhen-Yuan, Toluene nitration catalyzed by metal triflates, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 26（8）, 1111-1114, 200629.  Du, Xiaohua*; Zheng, Mei; Chen, Sheng; Xu, Zhenyuan, Novel synthesis of N-arylamides from nitroarenes via reductive N-acylation with red phosphorus and iodine, SYNLETT, 12, 1953-1955, 200630.  Du, XH; Chen, S; Zheng, M; Xu, ZY, A novel synthesis of 2-chloro-4-fluoro-5-nitrobenzenesulfonyl chloride, ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 37（6）, 566-569, 200531.  Xu, ZY; Du, XH; Xu, XS; Ni, YB, A new approach for the synthesis of 4-chloro-2-fluoronitrobenzene, JOURNAL OF CHEMICAL RESEARCH, 7, 496-497, 200432.  Xu, ZY; Du, XH; Gu, JB, Methyl 2-chloro-4-fluorophenylthioacetate as a new intermediate in the synthesis of pesticides, ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 35（4）, 439-443, 200333.  Xu, ZY; Du, XH; Su, WK, A facile method for preparation of aromatic isocyanates using bis(trichloromethyl)carbonate, JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 79（12）, 962-963, 2002 三、专利1.         杜晓华;崔梦龙, 一种草铵膦的合成方法, 201910042722.6, 授权日：2021-08-032.         杜晓华;郝树林, 含杂环二芳胺基吡唑甲酰胺类化合物及其制备方法与应用, 201811100793.9, 授权日：2021-05-113.         杜晓华;郝树林, 不饱和烃嘧啶硫醚类化合物及其制备方法与应用, 201810160958.5, 授权日：2020-10-274.         杜晓华;郝树林, 取代（杂）芳基亚甲基吡唑醚类化合物及其制备方法与应用, 201810160953.2, 授权日：2020-12-255.         杜晓华;郝树林, 取代（杂）芳基亚甲基嘧啶醚类化合物及其制备方法与应用, 201810160952.8, 授权日：2020-12-256.         杜晓华,毛达杰,徐振元, OXIME ETHER ACETATE COMPOUND, PREPARATION METHOD THEREFOR AND WEEDING APPLICATION THEREOF, US9884823B2(PCT/CN2015/072976), 授权日：2018-02-067.         杜晓华,毛达杰,徐振元, 一种肟醚乙酸酯类化合物及其制备方法与除草应用, 201410452170.3, 授权日：2016-07-068.         毛达杰,杜晓华,徐振元, 一种甲氧基氨基甲酸酯类化合物及其制备方法与应用, 201410088072.6, 授权日：2016-02-179.         杜晓华,徐振元, 2-取代基-4-甲砜基-α,α,α-三氯甲苯及其制备方法与应用, 201310636781.9, 授权日：2016-03-0910.     杜晓华,郑旺,赵琦君,徐振元, 一种2,3-二氯-5-甲基吡啶的合成方法, 201310344788.3, 授权日：2015-09-2311.     杜晓华,许丹倩,王益锋,夏爱宝, 除草剂中间体1,3-二（2-氯-4-三氟甲基苯氧基）苯的合成方法, 201210326520.2, 授权日：2014-12-0312.     杜晓华,周显峰,田晓宏,谢思勉, 一种N-取代基-3-胺基丙烯醛的合成方法, 201210037269.8, 授权日：2014-07-0213.     杜晓华,李以名,徐振元, 一种草胺磷的制备方法, 201210025815.6, 授权日：2015-03-0414.     杜晓华,李惠跃,胡智燕,陈静华,任旭康,吴江伟,徐振元, 一种处理和利用三氟甲基苯氨蒸馏釜残的方法（16届专利奖）, 200910097957.1, 授权日：2012-07-2515.     杜晓华,陈瑨,徐振元, 一种3-甲氧基丙醛的合成方法, 200810163498.8, 授权日：2012-06-2716.     杜晓华,骆大为,徐振元, 一种2,6-二硝基-3,4-而甲苯烷基醚的合成方法, 200810121863.9, 授权日：2012-05-2317.     杜晓华,严中杰,徐振元, 一种5-氨基-1-（2,6-二氯-4-三氟甲基苯基）-3-氰基吡唑, 200710156221.8, 授权日：2010-03-1018.     杜晓华,徐振元,许丹倩,吴庆安,张雅凤,浦晓英,沈宙,沈寅初, 井冈羟胺A-4,7,4,7-二缩醛或酮类化合物及其制备与应, 200510049079.7, 授权日：2008-02-2019.     杜晓华,郑鹏,徐振元, 2-氯-4-氟-5-硝基苯磺酰氯的制备方法, 200410089249.0, 授权日：2006-07-2620.     杜晓华,徐振元, 二（2-氯-4-氟苯基）二硫化物及其制备与应用, 200410089248.6, 授权日：2006-07-2621.     杜晓华,徐振元,俞峰,马肖克, 5-氯-2-硝基苯胺的化学合成方法, 2143481.6, 授权日：2004-12-2922.     徐振元,杜晓华, 4-氯-2-氟硝基苯的化学合成方法, 2130089.5, 授权日：2004-08-18 社会服务